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BGC0001773PKS

Selvamicin

Producing organism
Pseudonocardia sp. HH130630-07
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Pseudonocardia
Biosynthetic class
PKS (Unknown)
Total steps
26
DOI
MIBiG entry
View on MIBiG ↗
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selvamicin
C47H76O17912.51 Da

Gene Cluster Map29 genes · 109,444 bp

20 kb109.4 kb visible · 109,444 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

26 steps · 25 edges
Step 1Load
AFB00_29735
+Methylmalonyl-CoA
Inactive: AT, DH
Step 17
Start
+Glucose-1-phospha…
Step 25
Start
+L-Rhamnose
Step 2M1
AFB00_29730
Step 18
AFB00_29760
Step 3M2
AFB00_29730
Step 19
AFB00_29755
Step 4M3
AFB00_29725
Step 20
AFB00_29740
Step 5M4
AFB00_29725
Step 21
AFB00_29745
Step 6M5
AFB00_29725
Step 22
AFB00_29765
Step 7M6
AFB00_29725
Step 23
AFB00_29770
Step 8M7
AFB00_29780
Step 9M8
AFB00_29780
Step 10M9
AFB00_29780
Step 11M10
AFB00_29780
Step 12M11
AFB00_29780
Inactive: KR
Step 13M12
AFB00_29780
Step 14M13
AFB00_29775
Inactive: DH, ER
Step 15M14
AFB00_29720
Step 16TE
AFB00_29720
Step 24
AFB00_29750
Step 26
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions26 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11773-1AFB00_29735Loading
Methylmalonyl-CoA
OC(CC)=O{'Inactive': ['AT', 'DH']}
21773-2AFB00_29730M1
1773-1
from: 1773-1
OC(C(C(O)CC)C)=O—
31773-3AFB00_29730M2
1773-2
from: 1773-2
CC(C(C(C(O)CC)C)O)C(O)=O—
41773-4AFB00_29725M3
1773-3
from: 1773-3
CC(C(C(C(O)CC)C)O)/C=C/C(O)=O—
51773-5AFB00_29725M4
1773-4
from: 1773-4
CC(C(C(C(O)CC)C)O)/C=C/C=C/C(O)=O—
61773-6AFB00_29725M5
1773-5
from: 1773-5
CC(C(C(C(O)CC)C)O)/C=C/C=C/C=C/C(O)=O—
71773-7AFB00_29725M6
1773-6
from: 1773-6
CC(C(C(C(O)CC)C)O)/C=C/C=C/C=C/C=C/C(O)=O—
81773-8AFB00_29780M7
1773-7
from: 1773-7
OC(/C=C/C=C/C=C/C=C/C=C/C(C(C(C(O)CC)C)O)C)=O—
91773-9AFB00_29780M8
1773-8
from: 1773-8
OC(CC(/C=C/C=C/C=C/C=C/C=C/C(C(C(C(O)CC)C)O)C)O)=O—
101773-10AFB00_29780M9
1773-9
from: 1773-9
OC([C@H]([C@H](CC(/C=C/C=C/C=C/C=C/C=C/C(C(C(C(O)CC)C)O)C)O)O)C)=O—
111773-11AFB00_29780M10
1773-10
from: 1773-10
OC(C[C@H]([C@H]([C@H](CC(/C=C/C=C/C=C/C=C/C=C/C(C(C(C(O)CC)C)O)C)O)O)C)O)=O—
121773-12AFB00_29780M11
1773-11
from: 1773-11
OC(CC(C[C@H]([C@H]([C@H](CC(/C=C/C=C/C=C/C=C/C=C/C(C(C(C(O)CC)C)O)C)O)O)C)O)=O)=O{'Inactive': ['KR']}
131773-13AFB00_29780M12
1773-12
from: 1773-12
OC(C[C@@H](CC(C[C@H]([C@H]([C@H](CC(/C=C/C=C/C=C/C=C/C=C/C(C(C(C(O)CC)C)O)C)O)O)C)O)=O)O)=O—
141773-14AFB00_29775M13
1773-13
from: 1773-13
OC(C[C@@H](C[C@@H](CC(C[C@H]([C@H]([C@H](CC(/C=C/C=C/C=C/C=C/C=C/C(C(C(C(O)CC)C)O)C)O)O)C)O)=O)O)O)=O{'Inactive': ['DH', 'ER']}
151773-15AFB00_29720M14
1773-14
from: 1773-14
O=C(O)CCC[C@@H](C[C@@H](CC(C[C@H]([C@H]([C@H](CC(/C=C/C=C/C=C/C=C/C=C/C(C(C(C(O)CC)C)O)C)O)O)C)O)=O)O)O—
161773-16AFB00_29720TE
1773-15
from: 1773-15
CC(C(O)C(C)/C=C/C=C/C=C/C=C/C=C/C(O)C1)C(CC)OC(CCC[C@@H](C[C@@H](C[C@@]2(O)O[C@@H]1[C@H](C)[C@@H](O)C2)O)O)=O—
171773-17Start—
Glucose-1-phosphate
O[C@@H]([C@H](O)[C@H]1O)[C@@H](CO)O[C@@H]1OP([O-])([O-])=O—
181773-18AFB00_29760—
1773-17
from: 1773-17
[R][C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O—
191773-19AFB00_29755—
1773-18
from: 1773-18
[R][C@H]1O[C@H](C)C([C@H](O)[C@H]1O)=O—
201773-20AFB00_29740—
1773-19
from: 1773-19
[R][C@H]1O[C@H](C)C(C(C1)=O)=O—
211773-21AFB00_29745—
1773-20
from: 1773-20
[R][C@H]1O[C@H](C)C([C@H](O)C1)=O—
221773-22AFB00_29765—
1773-21
from: 1773-21
[R][C@H]1O[C@@H](C)C([C@H](O)C1)=O—
231773-23AFB00_29770—
1773-22
from: 1773-22
[R][C@@H]1O[C@@H](C)[C@H](OC)[C@H](O)C1—
241773-24AFB00_29750—
1773-16;1773-23
from: 1773-16, 1773-23
CC(C(O[C@@H]1O[C@@H](C)[C@H](OC)[C@H](O)C1)C(C)/C=C/C=C/C=C/C=C/C=C/C(O)C2)C(CC)OC(CCC[C@@H](C[C@@H](C[C@@]3(O)O[C@@H]2[C@@](C)(O)[C@@H](O)C3)O)O)=O—
251773-25Start—
L-Rhamnose
O[C@@H]1O[C@H](C)[C@@H](O)[C@H](O)[C@@H]1O—
261773?—
1773-24;1773-25
from: 1773-24, 1773-25
CC(C(O[C@@H]1O[C@@H](C)[C@H](OC)[C@H](O)C1)C(C)/C=C/C=C/C=C/C=C/C=C/C(O[C@@H]2O[C@H](C)[C@@H](O)[C@H](O)[C@@H]2O)C3)C(CC)OC(CC[C@@H](O)[C@@H](C[C@@H](C[C@@]4(O)O[C@@H]3[C@@](C)(O)[C@@H](O)C4)O)O)=O—
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