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BGC0001770PKS

Sceliphrolactam

Producing organism
Streptomyces sp. SD85
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
18
DOI
MIBiG entry
View on MIBiG ↗
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sceliphrolactam
C28H35NO6481.25 Da

Gene Cluster Map25 genes · 94,427 bp

20 kb94.4 kb visible · 94,427 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

18 steps · 17 edges
Step 1
Start
+L-Glutamine
Step 2
ANH11407.1, ANH11408.1
Step 3
ANH11404.1;ANH11403.1
Step 4
ANH11406.1
Step 5
ANH11405.1
Step 6Load
ANH11402.1;ANH11409.1
Step 7M1
ANH11409.1
+Malonyl-CoA
Step 8M2
ANH11409.1
+Malonyl-CoA
Step 9M3
ANH11410.1
+Methylmalonyl-CoA
Step 10M4
ANH11410.1
+Malonyl-CoA
Step 11M5
ANH11412.1
Iterative
Step 12M6
ANH11413.1
Iterative
Step 13M7
ANH11414.1
+Malonyl-CoA
Step 14M8
ANH11414.1
+Methylmalonyl-CoA
Step 15M9
ANH11414.1
+Malonyl-CoA
Step 16M10
ANH11415.1
+Malonyl-CoA
Step 17TE
ANH11415.1, ANH11401.1
Step 18
ANH11399.1, ANH11400.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions18 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11770-1Start—
L-Glutamine
N[C@H](C(O)=O)CCC(O)=O—
21770-2ANH11407.1, ANH11408.1—
1770-1
from: 1770-1
N[C@H](C(O)=O)[C@H](C)C(O)=O—
31770-3ANH11404.1;ANH11403.1—
1770-2
from: 1770-2
N[C@H](C(O)=O)[C@H](C)C(O)=O—
41770-4ANH11406.1—
1770-3
from: 1770-3
OC([C@@H](CN)C)=O—
51770-5ANH11405.1—
1770-4
from: 1770-4
OC([C@@H](CNC([R])=O)C)=O—
61770-6ANH11402.1;ANH11409.1Loading
1770-5
from: 1770-5
OC([C@@H](CNC([R])=O)C)=O—
71770-7ANH11409.1M1
1770-6;Malonyl-CoA
from: 1770-6
C[C@H](CNC([R])=O)/C=C/C(O)=O—
81770-8ANH11409.1M2
1770-7;Malonyl-CoA
from: 1770-7
C[C@H](CNC([R])=O)/C=C/C=C/C(O)=O—
91770-9ANH11410.1M3
1770-8;Methylmalonyl-CoA
from: 1770-8
C[C@H](CNC([R])=O)/C=C/C=C/C=C(C(O)=O)\C—
101770-10ANH11410.1M4
1770-9;Malonyl-CoA
from: 1770-9
C[C@H](CNC([R])=O)/C=C/C=C/C=C(/C=C/C(O)=O)C—
111770-11ANH11412.1M5
1770-10
from: 1770-10
C[C@H](CNC([R])=O)/C=C/C=C/C=C(/C=C/C=C/C(CC(O)=O)=O)C{'Iteration': [(['DH', 'KR']…
121770-12ANH11413.1M6
1770-11
from: 1770-11
C[C@H](CNC([R])=O)/C=C/C=C/C=C(/C=C/C=C/C(C[C@H](CC(O)=O)O)=O)C{'Iteration': [((['None'], '…
131770-13ANH11414.1M7
1770-12;Malonyl-CoA
from: 1770-12
C[C@H](CNC([R])=O)/C=C/C=C/C=C(/C=C/C=C/C(C[C@H](C/C=C/C(O)=O)O)=O)C—
141770-14ANH11414.1M8
1770-13;Methylmalonyl-CoA
from: 1770-13
C[C@H](CNC([R])=O)/C=C/C=C/C=C(/C=C/C=C/C(C[C@H](C/C=C/C=C(C)/C(O)=O)O)=O)C—
151770-15ANH11414.1M9
1770-14;Malonyl-CoA
from: 1770-14
C[C@H](CNC([R])=O)/C=C/C=C/C=C(/C=C/C=C/C(C[C@H](C/C=C/C=C(C)/C=C/C(O)=O)O)=O)C—
161770-16ANH11415.1M10
1770-15;Malonyl-CoA
from: 1770-15
C[C@H](CNC([R])=O)/C=C/C=C/C=C(/C=C/C=C/C(C[C@H](C/C=C/C=C(C)/C=C/C(CC(O)=O)=O)O)=O)C—
171770-17ANH11415.1, ANH11401.1TE
1770-16
from: 1770-16
OC(/C=C/C(C)=C/C=C/C[C@H](O)CC1=O)=C\C(NC[C@@H](C)/C=C/C=C/C=C(/C=C/C=C\1)C)=O—
181770ANH11399.1, ANH11400.1—
1770-17
from: 1770-17
OC(/C=C/C(C)=C/C=C/C(O)[C@H](O)C(O)C1=O)=C\C(NC[C@@H](C)/C=C/C=C/C=C(/C=C/C=C\1)C)=O—
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