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BGC0001763Hybrid

Rufomycin

Producing organism
Streptomyces atratus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
20
DOI
MIBiG entry
—
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rufomycin
C54H77N9O101011.58 Da

Pathway Graphsteps arranged in biosynthetic order

20 steps · 19 edges
Step 1
Start
+Tryptophan
Step 5
Start
+Tyrosine
Step 11
Start
Step 2
rufP
Step 6
rufN, rufO
+Arginine
Step 12
rufE
Step 3M1
rufT
Step 13
rufE
+Malonyl-CoA
{'Missing': ['AT']}
Step 4M2
rufT
+Leucine
Step 14
rufE
+Malonyl-CoA
Step 7M3
rufT
Step 15
rufC
Step 8M4
rufT
+Alanine
Step 16
rufC
Step 9M5
rufT
+Leucine
Step 17
rufI
Step 10M6
rufT
+Leucine
Step 18
rufF
Step 19M7
rufT
Step 20TE
rufT, (rufM, rufS)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions20 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11763-1Start—
Tryptophan
OC([C@@H](N)CC1=CNC2=C1C=CC=C2)=O—
21763-2rufP—
1763-1
from: 1763-1
OC([C@@H](N)CC1=CN(C(C)(C)C=C)C2=C1C=CC=C2)=O—
31763-3rufTM1
1763-2
from: 1763-2
OC([C@@H](N)CC1=CN(C(C)(C)C=C)C2=C1C=CC=C2)=O—
41763-4rufTM2
1763-3;Leucine
from: 1763-3
OC([C@@H](N(C([C@@H](N)CC1=CN(C(C)(C)C=C)C2=C1C=CC=C2)=O)C)CC(C)C)=O—
51763-5Start—
Tyrosine
OC1=CC=C(C[C@H](N)C(O)=O)C=C1—
61763-6rufN, rufO—
1763-5;Arginine
from: 1763-5
OC1=C([N+]([O-])=O)C=C(C[C@H](N)C(O)=O)C=C1—
71763-7rufTM3
1763-4;1763-6
from: 1763-4, 1763-6
OC([C@@H](NC([C@@H](N(C([C@@H](N)CC1=CN(C(C)(C)C=C)C2=C1C=CC=C2)=O)C)CC(C)C)=O)CC3=CC=C(O)C([N+]([O-])=O)=C3)=O—
81763-8rufTM4
1763-7;Alanine
from: 1763-7
OC([C@@H](NC([C@@H](NC([C@@H](N(C([C@@H](N)CC1=CN(C(C)(C)C=C)C2=C1C=CC=C2)=O)C)CC(C)C)=O)CC3=CC=C(O)C([N+]([O-])=O)=C3)=O)C)=O—
91763-9rufTM5
1763-8;Leucine
from: 1763-8
OC([C@@H](N(C([C@@H](NC([C@@H](NC([C@@H](N(C([C@@H](N)CC1=CN(C(C)(C)C=C)C2=C1C=CC=C2)=O)C)CC(C)C)=O)CC3=CC=C(O)C([N+]([O-])=O)=C3)=O)C)=O)C)CC(C)C)=O—
101763-10rufTM6
1763-9;Leucine
from: 1763-9
OC([C@@H](NC([C@@H](N(C([C@@H](NC([C@@H](NC([C@@H](N(C([C@@H](N)CC1=CN(C(C)(C)C=C)C2=C1C=CC=C2)=O)C)CC(C)C)=O)CC3=CC=C(O)C([N+]([O-])=O)=C3)=O)C)=O)C)CC(C)C)=O)CC(C)C)=O—
111763-11Start—
O=C(C)O[Na]—
121763-12rufE—
1763-11
from: 1763-11
O=C(C)O—
131763-13rufE—
1763-12;Malonyl-CoA
from: 1763-12
O=C(/C=C/C)O{'Missing': ['AT']}
141763-14rufE—
1763-13;Malonyl-CoA
from: 1763-13
O=C(CC/C=C/C)O—
151763-15rufC—
1763-14
from: 1763-14
O=C(C(O)C/C=C/C)O—
161763-16rufC—
1763-15
from: 1763-15
O=C(C(C/C=C/C)=O)O—
171763-17rufI—
1763-16
from: 1763-16
O=C([C@@H](N)C/C=C/C)O—
181763-18rufF—
1763-17
from: 1763-17
O=C([C@@H](N)C/C=C/C)O—
191763-19rufTM7
1763-10;1763-18
from: 1763-10, 1763-18
O=C(C(NC([C@@H](NC([C@@H](N(C([C@@H](NC([C@@H](NC([C@@H](N(C([C@@H](N)CC1=CN(C(C)(C)C=C)C2=C1C=CC=C2)=O)C)CC(C)C)=O)CC3=CC=C(O)C([N+]([O-])=O)=C3)=O)C)=O)C)CC(C)C)=O)CC(C)C)=O)C/C=C/C)O—
201763rufT, (rufM, rufS)TE
1763-19
from: 1763-19
CC(C)C[C@H](N(C)C([C@H](C)NC([C@H](CC1=CC=C(O)C(C)=C1)NC([C@H](CC(C)C)N(C([C@H](CC2=CN(C(C)(C)C=C)C3=C2C=CC=C3)N4)=O)C)=O)=O)=O)C(N[C@@H](CC(C)C)C(NC(C/C=C/C)C4=O)=O)=O—
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