NPdia

BGC0001760NRPS

Rimosamide

Producing organism: Streptomyces rimosus subsp. rimosus ATCC 10970
Taxonomy: Bacteria›Actinobacteria›Streptomycetales›Streptomycetaceae›Streptomyces
Biosynthetic class: NRPS (Type I)
Total steps: 9
DOI: 10.1021/acschembio.6b00779
MIBiG entry: View on MIBiG ↗

Biosynthetic (core)

Biosynthetic (additional)

Regulatory

Unknown

Domains

Ketosynthase (KS)

Ketoreductase (KR)

Condensation (C)

Adenylation (A)

Peptidyl carrier (PCP)

Acyl carrier (ACP)

Thioesterase (TE)

TauD oxygenase

9 steps · 8 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions9 steps

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`1760-1`	SRIM_RS28570	M1	Isoleucine	`N[C@H](C(O)=O)C(CC)C`	—
2	`1760-2`	SRIM_RS28570	M2	1760-1;Proline from: 1760-1	`N[C@H](C(N1[C@H](C(O)=O)CCC1)=O)C(CC)C`	—
3	`1760-3`	SRIM_RS28570	M3	1760-2;Malonyl-CoA from: 1760-2	`N[C@H](C(N1[C@H](C(CC(O)=O)=O)CCC1)=O)C(CC)C`	—
4	`1760-4`	SRIM_RS28570	—	1760-3 from: 1760-3	`N[C@H](C(N1[C@H]([C@@H](O)CC(O)=O)CCC1)=O)C(CC)C`	—
5	`1760-5`	SRIM_RS28560	—	Isobutyrate;Glycine	`O=C(C(C)C)NCC(O)=O`	—
6	`1760-6`	SRIM_RS28565	—	1760-5;Phenylalanine from: 1760-5	`O=C(C(C)C)NCC(N[C@@H](CC1=CC=CC=C1)C(O)=O)=O`	—
7	`1760-7`	?	—	1760-4;1760-6 from: 1760-4, 1760-6	`O=C(C(C)C)NCC(N[C@H](C(O[C@@H](CC(O)=O)[C@H](CCC1)N1C([C@H](C(CC)C)N)=O)=O)CC2=CC=CC=C2)=O`	—
8	`1760-8`	SRIM_RS28570	TE	1760-7 from: 1760-7	`O=C(C(C)C)NCC(N[C@H](C(O[C@@H](CC(O)=O)[C@H](CCC1)N1C([C@H](C(CC)C)N)=O)=O)CC2=CC=CC=C2)=O`	—
9	`1760`	?	—	1760-8 from: 1760-8	`O=C(C(C)C)NCC(N[C@H](C(O[C@@H](CC(O)=O)[C@@]([C@H](OC(C)=O)CC1)([H])N1C([C@H](C(CC)C)N)=O)=O)CC2=CC=CC=C2)=O`	—

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