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BGC0001759PKS

Rifamorpholine A;Rifamorpholine B;Rifamorpholine C;Rifamorpholine D;Rifamorpholine E

Producing organism
Amycolatopsis sp
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Amycolatopsis
Biosynthetic class
PKS (Unknown)
Total steps
22
DOI
MIBiG entry
View on MIBiG ↗
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C37H45NO13711.29 Da

Gene Cluster Map63 genes · 113,830 bp

20 kb113.8 kb visible · 113,830 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
MTMethyltransferase
CALCoA-ligase (CAL)
AmTAminotransferase I/II
AmTAminotransferase III

Pathway Graphsteps arranged in biosynthetic order

22 steps · 21 edges
Step 1Load
AWH12671.1
+AHBA
Step 2M1
AWH12671.1
+Methylmalonyl-CoA
Inactive: DH
Step 3M2
AWH12671.1
+Malonyl-CoA
Step 4M3
AWH12670.1
+Methylmalonyl-CoA
Step 5M4
AWH12639.1, AWH12669.1
+Methylmalonyl-CoA
Step 6M5
AWH12669.1
+Methylmalonyl-CoA
Inactive: DH
Step 7M6
AWH12669.1
+Methylmalonyl-CoA
Inactive: DH
Step 8M7
AWH12668.1
+Methylmalonyl-CoA
Inactive: DH
Step 9M8
AWH12667.1;AWH12666.1
+Methylmalonyl-CoA
Inactive: DH
Step 10M9
AWH12665.1;AWH12664.1
Step 11M10
AWH12664.1
+Methylmalonyl-CoA
Step 12
AWH12663.1
Step 13
AWH12674.1, (AWH12642.1…
Step 14
Step 15
?
Step 16
AWH12635.1, AWH12638.1
Step 18
?
Step 17
?
Step 19
?
Step 20
?
Step 21
?
Step 22
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions22 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11759-1AWH12671.1Loading
AHBA
OC1=CC(N)=CC(C(O)=O)=C1—
21759-2AWH12671.1M1
1759-1;Methylmalonyl-CoA
from: 1759-1
OC1=CC(N)=CC(C(O)C(C(O)=O)C)=C1{'Inactive': ['DH']}
31759-3AWH12671.1M2
1759-2;Malonyl-CoA
from: 1759-2
OC1=CC(N)=CC(C(O)C(C(CC(O)=O)=O)C)=C1—
41759-4AWH12670.1M3
1759-3;Methylmalonyl-CoA
from: 1759-3
OC1=CC(N)=CC(C(O)C(C(CC(C(C(O)=O)C)=O)=O)C)=C1—
51759-5AWH12639.1, AWH12669.1M4
1759-4;Methylmalonyl-CoA
from: 1759-4
CC(C(O)=O)/C=C(C(C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O)=O)\C—
61759-6AWH12669.1M5
1759-5;Methylmalonyl-CoA
from: 1759-5
CC(C(O)C(C(O)=O)C)/C=C(C(C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O)=O)\C{'Inactive': ['DH']}
71759-7AWH12669.1M6
1759-6;Methylmalonyl-CoA
from: 1759-6
CC(C(O)C(C(O)C(C(O)=O)C)C)/C=C(C(C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O)=O)\C{'Inactive': ['DH']}
81759-8AWH12668.1M7
1759-7;Methylmalonyl-CoA
from: 1759-7
CC(C(O)C(C(O)C(C(O)C(C(O)=O)C)C)C)/C=C(C(C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O)=O)\C{'Inactive': ['DH']}
91759-9AWH12667.1;AWH12666.1M8
1759-8;Methylmalonyl-CoA
from: 1759-8
CC(C(O)C(C(O)C(C(O)C(C(O)C(C(O)=O)C)C)C)C)/C=C(C(C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O)=O)\C{'Inactive': ['DH']}
101759-10AWH12665.1;AWH12664.1M9
1759-9Malonyl-CoA
from: 1759-9Malonyl-CoA
CC(C(O)C(C(O)C(C(O)C(C(O)C(/C=C/C(O)=O)C)C)C)C)/C=C(C(C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O)=O)\C—
111759-11AWH12664.1M10
1759-10;Methylmalonyl-CoA
from: 1759-10
CC(C(O)C(C(O)C(C(O)C(C(O)C(/C=C/C=C(C(O)=O)\C)C)C)C)C)/C=C(C(C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O)=O)\C—
121759-12AWH12663.1—
1759-11
from: 1759-11
C[C@@H]([C@@H](O)C(C=C1C)C)[C@@H](O)[C@H](C)[C@@H]([C@H](C)[C@H]([C@@H](C)/C=C/C=C(C)\C(NC(C(C2=C3C(C1=O)=C(O)C(C)C2O)=O)=CC3=O)=O)O)O—
131759-13AWH12674.1, (AWH12642.1, AWH12641.1)?, AWH12675.1?, AWH12648.1—
1759-12
from: 1759-12
C[C@@H]([C@@H](O)/C=C/OC(C1=O)(C)O2)[C@@H](O)[C@H](C)[C@@H]([C@H](C)[C@H]([C@](C)([H])/C=C/C=C(C)\C(NC(C(C3=C4C1=C2C(C)=C3O)=O)=CC4=O)=O)O)O—
141759-14—
1759-13
from: 1759-13
OC(/N=C1C(C(C(C(O)=C\1)=C2C3=O)=C4O)=O)=C(C)/C=C/C=C(C)\[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)/C=C/O[C@H]3OC2=C4C—
151759-15?—
1759-14
from: 1759-14
OC(C(O1)(C)/C=C/C=C(C)\[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)/C=C/O[C@@]2(C)OC3=C4C)=NC5=C1C(C(C(O)=C5)=C3C2=O)=C4O—
161759-16AWH12635.1, AWH12638.1—
1759-15
from: 1759-15
O=C1[C@@]2(C)OC(C3=C(C(C)=C4OC5(C)O/C=C/[C@H](OC)[C@@H](C)[C@H]([C@H](C)[C@@H]([C@H](C)[C@H](/C(C)=C\C=C\2)O)O)OC(C)=O)O)=C(N1)C(O)=C(O)C3=C4C5=O—
171759(1)?—
1759-16
from: 1759-16
O=C1[C@@]2(C)OC(C3=C(C(C)=C4OC5(C)O/C=C/[C@H](OC)[C@@H](C)[C@H]([C@H](C)[C@@H]([C@H](C)[C@@H](/C(C)=C\C=C\2)O)O)OC(C)=O)O)=C(N1)C(O)=C(O)C3=C4C5=O—
181759-17?—
1759-15
from: 1759-15
O=C1[C@@]2(C)OC(C3=C(C(C)=C4OC5(C)O/C=C/[C@H](OC)[C@@H](C)[C@H]([C@H](C)[C@@H]([C@H](C)[C@H](/C(C)=C\C=C\2)O)O)O)O)=C(N1)C=C(O)C3=C4C5=O—
191759(2)?—
1759-17
from: 1759-17
O=C1[C@@](C2)(C)OC(C3=C(C(C)=C4OC5(C)O/C=C/[C@H](OC)[C@@H](C)[C@H]([C@H](C)[C@@H]([C@H](C)[C@H](C(C6)C6C2=O)O)O)O)O)=C(N1)C([H])=C(O)C3=C4C5=O—
201759(3)?—
1759-17
from: 1759-17
O=C1[C@@](C2)(C)OC(C3=C(C(C)=C4OC5(C)O/C=C/[C@H](OC)[C@@H](C)[C@H]([C@H](C)[C@@H]([C@H](C)[C@H](C(C6)C6C2=O)O)O)OC(C)=O)O)=C(N1)C([H])=C(O)C3=C4C5=O—
211759(4)?—
1759-17
from: 1759-17
O=C1[C@@](C2)(C)OC(C3=C(C(C)=C4OC5(C)O/C=C/[C@H](OC)[C@@H](C)[C@H]([C@H](C)[C@@H]([C@H](C)[C@H](C(C6)C6C2=O)O)O)O)O)=C(N1)C(O)=C(O)C3=C4C5=O—
221759(5)?—
1759-17
from: 1759-17
O=C1[C@@](C2)(C)OC(C3=C(C(C)=C4OC5(C)O/C=C/[C@H](OC)[C@@H](C)[C@H]([C@H](C)[C@@H]([C@H](C)[C@H](C(C6)C6C2=O)O)O)OC(C)=O)O)=C(N1)C(O)=C(O)C3=C4C5=O—
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