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BGC0001755PKS

Reedsmycin A;Reedsmycin B;Reedsmycin C;Reedsmycin D;Reedsmycin E

Producing organism
Streptomyces sp
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
22
DOI
MIBiG entry
View on MIBiG ↗
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C36H58O10650.85 Da

Gene Cluster Map20 genes · 103,914 bp

20 kb103.9 kb visible · 103,914 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

22 steps · 21 edges
Step 1Load
rdmG
+Malonyl-CoA
Step 2M1
rdmG
+Methylmalonyl-CoA
Step 3M2
rdmG
+Methylmalonyl-CoA
Inactive: DH
Step 4M3
rdmH
+Malonyl-CoA
Step 5M4
rdmH
+Malonyl-CoA
Step 6M5
rdmH
+Malonyl-CoA
Step 7M6
rdmH
+Malonyl-CoA
Step 8M7
rdmI
+Malonyl-CoA
Step 9M8
rdmI
+Malonyl-CoA
Step 10M9
rdmI
+Malonyl-CoA
Step 11M10
rdmI
+Malonyl-CoA
Step 12M11
rdmI
+Malonyl-CoA
Step 13M12
rdmI
+Malonyl-CoA
Step 14M13
rdmJ
+Malonyl-CoA
Step 15M14
rdmJ
+Malonyl-CoA
Step 16M15
rdmJ
+Malonyl-CoA
Step 17M16
rdmJ
+Malonyl-CoA
Step 18TE
rdmJ
Step 19TE
rdmJ
Step 20TE
rdmJ
Step 21TE
rdmJ
Step 22TE
rdmJ
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions22 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11755-1rdmGLoading
Malonyl-CoA
O=C(O)C—
21755-2rdmGM1
1755-1;Methylmalonyl-CoA
from: 1755-1
CCC(C)C(O)=O—
31755-3rdmGM2
1755-2;Methylmalonyl-CoA
from: 1755-2
CCC(C)C(O)C(C)C(O)=O{'Inactive': ['DH']}
41755-4rdmHM3
1755-3;Malonyl-CoA
from: 1755-3
CCC(C)C(O)C(C)/C=C/C(O)=O—
51755-5rdmHM4
1755-4;Malonyl-CoA
from: 1755-4
CCC(C)C(O)C(C)/C=C/C(O)CC(O)=O—
61755-6rdmHM5
1755-5;Malonyl-CoA
from: 1755-5
CCC(C)C(O)C(C)/C=C/C(O)CC(O)CC(O)=O—
71755-7rdmHM6
1755-6;Malonyl-CoA
from: 1755-6
CCC(C)C(O)C(C)/C=C/C(O)CC(O)CC(O)CC(O)=O—
81755-8rdmIM7
1755-7;Malonyl-CoA
from: 1755-7
CCC(C)C(O)C(C)/C=C/C(O)CC(O)CC(O)CC(O)CC(O)=O—
91755-9rdmIM8
1755-8;Malonyl-CoA
from: 1755-8
CCC(C)C(O)C(C)/C=C/C(O)CC(O)CC(O)CC(O)CC(O)CC(O)=O—
101755-10rdmIM9
1755-9;Malonyl-CoA
from: 1755-9
CCC(C)C(O)C(C)/C=C/C(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(O)=O—
111755-11rdmIM10
1755-10;Malonyl-CoA
from: 1755-10
CCC(C)C(O)C(C)/C=C/C(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(O)=O—
121755-12rdmIM11
1755-11;Malonyl-CoA
from: 1755-11
CCC(C)C(O)C(C)/C=C/C(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(O)=O—
131755-13rdmIM12
1755-12;Malonyl-CoA
from: 1755-12
CCC(C)C(O)C(C)/C=C/C(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(O)C/C=C/C(O)=O—
141755-14rdmJM13
1755-13;Malonyl-CoA
from: 1755-13
CCC(C)C(O)C(C)/C=C/C(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(O)C/C=C/C=C/C(O)=O—
151755-15rdmJM14
1755-14;Malonyl-CoA
from: 1755-14
CCC(C)C(O)C(C)/C=C/C(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(O)C/C=C/C=C/C=C/C(O)=O—
161755-16rdmJM15
1755-15;Malonyl-CoA
from: 1755-15
CCC(C)C(O)C(C)/C=C/C(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(O)C/C=C/C=C/C=C/C=C/C(O)=O—
171755-17rdmJM16
1755-16;Malonyl-CoA
from: 1755-16
CCC(C)C(O)C(C)/C=C/C(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(O)C/C=C/C=C/C=C/C=C/C=C/C(O)=O—
181755(1)rdmJTE
1755-17
from: 1755-17
OC1CC(O)CC(O)CC(O)CC(O)CC(O)CC(O)/C=C/C(C)C(C(C)CC)OC(/C=C/C=C/C=C/C=C/C=C/CC(O)C1)=O—
191755(2)rdmJTE
1755-17
from: 1755-17
CCC(C1OC(/C=C/C=C/C=C\C=C\C=C\CC(CC(CC(CC(CC(CC(CC(CC(/C=C/C1C)O)O)O)O)O)O)O)O)=O)C—
201755(3)rdmJTE
1755-17
from: 1755-17
O=C1/C=C/C=C/C=C/C=C/C=C/CC(CC(CC(CC(CC(CC(CC(CC(/C=C/C(C(O1)C(CC)C)C)O)O)O)O)O)O)O)O—
211755(4)rdmJTE
1755-17
from: 1755-17
O=C1/C=C/C=C/C=C/C=C/C=C\CC(O)CC(CC(CC(CC(CC(CC(CC(/C=C/C(C(O1)C(CC)C)C)O)O)O)O)O)O)O—
221755(5)rdmJTE
1755-17
from: 1755-17
OC1/C=C/C(C)C(C(C)CC)OC(/C=C/C=C\C=C\C=C/C=C/CC(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(O)C1)=O—
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