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BGC0001740Hybrid

Phthoxazolin

Producing organism
Streptomyces avermitilis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
15
DOI
MIBiG entry
View on MIBiG ↗
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phthoxazolin
C16H22N2O3290.16 Da

Gene Cluster Map43 genes · 100,000 bp

20 kb100.0 kb visible · 100,000 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TdTrans-AT docking
DH2Dehydratase (DH2)
DHtDehydratase (DHt)
MTMethyltransferase
CycPolyketide cyclase
ACPSACP synthase
AmTAminotransferase I/II

Pathway Graphsteps arranged in biosynthetic order

15 steps · 14 edges
Step 1Load
ptxE
+Glycine
Step 2M1
ptxC
Trans-AT
Step 3M2
ptxF
Trans-AT
Step 4M3
ptxF
Trans-AT
Step 5M4
ptxF
Trans-AT
Step 6M5
ptxB
Trans-AT
Step 7M6
ptxB
+Glycine
Step 8M7
ptxB
Trans-AT
Step 9M8
ptxB
Trans-AT
Step 10M9
ptxB;ptxH
Inactive: KS, ACP1
Step 11M10
ptxH
Trans-AT
Step 12M11
ptxH
Inactive: KS
Step 13M12
ptxG
+Serine
Step 14M13
ptxG
+Tyrosine
Step 15
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions15 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11740-1ptxELoading
Glycine
O=C(O)CNC([H])=O—
21740-2ptxCM1
1740-1
from: 1740-1
O=C(CC(O)=O)CNC([H])=O{'transAT': ['ptxA', 'Malony…
31740-3ptxFM2
1740-2
from: 1740-2
O=C(O)/C=C/CC1=CN=CO1{'transAT': ['ptxA', 'Malony…
41740-4ptxFM3
1740-3
from: 1740-3
O=C(O)/C=C\C=C\CC1=CN=CO1{'transAT': ['ptxA', 'Malony…
51740-5ptxFM4
1740-4
from: 1740-4
C/C(C(O)=O)=C/C=C\C=C\CC1=CN=CO1{'transAT': ['ptxA', 'Malony…
61740-6ptxBM5
1740-5
from: 1740-5
C/C([C@@H](O)C(C)(C)C(O)=O)=C/C=C\C=C\CC1=CN=CO1{'transAT': ['ptxA', 'Malony…
71740-7ptxBM6
1740-6;Glycine
from: 1740-6
C/C([C@@H](O)C(C)(C)C(NCC(O)=O)=O)=C/C=C\C=C\CC1=CN=CO1—
81740-8ptxBM7
1740-7
from: 1740-7
C/C([C@@H](O)C(C)(C)C(NC/C=C/C(O)=O)=O)=C/C=C\C=C\CC1=CN=CO1{'transAT': ['ptxA', 'Malony…
91740-9ptxBM8
1740-8
from: 1740-8
C/C([C@@H](O)C(C)(C)C(NC/C=C/C(O)CC(O)=O)=O)=C/C=C\C=C\CC1=CN=CO1{'transAT': ['ptxA', 'Malony…
101740-10ptxB;ptxHM9
1740-9
from: 1740-9
C/C([C@@H](O)C(C)(C)C(NC/C=C/C=C/C(O)=O)=O)=C/C=C\C=C\CC1=CN=CO1{'Inactive': ['KS', 'ACP1']}
111740-11ptxHM10
1740-10
from: 1740-10
C/C([C@@H](O)C(C)(C)C(NC/C=C/C=C/C=C/C(O)=O)=O)=C/C=C\C=C\CC1=CN=CO1{'transAT': ['ptxA', 'Malony…
121740-12ptxHM11
1740-11
from: 1740-11
C/C([C@@H](O)C(C)(C)C(NC/C=C/C=C/C=C/C(O)=O)=O)=C/C=C\C=C\CC1=CN=CO1{'Inactive': ['KS']}
131740-13ptxGM12
1740-12;Serine
from: 1740-12
C/C([C@@H](O)C(C)(C)C(NC/C=C/C=C/C=C/C(NC(C(O)=O)CO)=O)=O)=C/C=C\C=C\CC1=CN=CO1—
141740-14ptxGM13
1740-13;Tyrosine
from: 1740-13
C/C([C@@H](O)C(C)(C)C(NC/C=C/C=C/C=C/C(NC(C(N(C)C(CC1=CC=C(O)C=C1)C(O)=O)=O)CO)=O)=O)=C/C=C\C=C\CC2=CN=CO2—
151740?—
1740-14
from: 1740-14
C/C([C@@H](O)C(C)(C)C(N)=O)=C/C=C\C=C\CC1=CN=CO1—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture