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BGC0001726Hybrid

Pactamide A;Pactamide B;Pactamide C;Pactamide D;Pactamide E;Pactamide F

Producing organism
Streptomyces pactum
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
11
DOI
MIBiG entry
View on MIBiG ↗
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C29H40N2O4480.60 Da

Gene Cluster Map9 genes · 31,637 bp

KSATDHKRCAER5 kb31.6 kb visible · 31,637 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)

Pathway Graphsteps arranged in biosynthetic order

11 steps · 10 edges
Step 1M1
APD26279.1
Iterative
Step 2M1
APD26279.1
Iterative
Step 3M2
APD26279.1
+L-Ornithine
Step 4
APD26279.1
Step 5
APD26281.1
Step 6
APD26280.1
+1726(1)
Step 7
APD26282.1
+1726(2)
Step 8
?
+1726(3)
Step 9
APD26278.1?
+1726(3)
Step 10
?
Step 11
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions11 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11726-1APD26279.1M1
C/C=C/C=C/C=C/C=C/C=C/C(O)=O{'Iteration': [(['None'], 'M…
21726-2APD26279.1M1
C/C=C/C=C/C=C/C=C/C(CC(O)=O)=O{'Iteration': [(['None'], 'M…
31726-3APD26279.1M2
L-Ornithine
O=C([C@@H](N)CCCN)O—
41726-4APD26279.1—
1726-1;1726-2;1726-3
from: 1726-1, 1726-2, 1726-3
O=C(/C=C/C=C/C=C/C=C/C)C1=C(O)[C@@](CCCNC(/C=C/C=C/C=C/C=C/C=C/C)=O)([H])NC1=O—
51726(1)APD26281.1—
1726-4
from: 1726-4
CC[C@H]1C[C@]2([H])[C@@]([H])(/C=C/C=C/C=C/C(C(C(N3)=O)=C(O)[C@]3([H])CCCNC(/C=C/C=C/C=C/2)=O)=O)[C@@H]1C—
61726(2)APD26280.1—
1726(1)
CC[C@H]1C[C@@]([C@]2([H])[C@@H]1C)([H])C[C@@]([C@]2([H])C/C=C/C=C/C(C(C(N3)=O)=C(O)[C@]3([H])CCCN4)=O)([H])/C=C/C=C/C4=O—
71726(3)APD26282.1—
1726(2)
CC[C@H]1C[C@@]2([H])C[C@@]3([H])[C@@](C/C=C\C(NCCC[C@@]4([H])C(O)=C5C(N4)=O)=O)([H])[C@](/C=C/C5=O)([H])CC[C@]3([H])[C@@]2([H])[C@@H]1C—
81726(4)?—
1726(3)
CC[C@H]1C[C@@]2([H])C[C@@]3([H])[C@@](C/C=C\C(NCCC[C@@]4([H])C(O)=C5C(N4)=O)=O)([H])[C@](/C=C/C5=O)([H])CC[C@]3([H])[C@@]2([H])[C@]1(O)CCl—
91726-5APD26278.1?—
1726(3)
CC[C@H]1C[C@@]2([H])C[C@@]3([H])[C@@](C/C=C\C(NCCC[C@@]4([H])C(O)=C5C(N4)=O)=O)([H])[C@](/C=C/C5=O)([H])CC[C@]3([H])[C@@]2([H])[C@@H]1CO—
101726(5)?—
1726-5
from: 1726-5
CCC1=C(CO)[C@@]2([H])[C@](C1)([H])C[C@@]3([H])[C@@](C/C=C\C(NCCC[C@@]4([H])C(O)=C5C(N4)=O)=O)([H])[C@](/C=C/C5=O)([H])CC[C@@]32[H]—
111726(6)?—
1726-5
from: 1726-5
CCC1=C[C@@]2([H])C[C@@]3([H])[C@@](C/C=C\C(NCCC[C@@]4([H])C(O)=C5C(N4)=O)=O)([H])[C@](/C=C/C5=O)([H])CC[C@]3([H])[C@@]2([H])[C@@H]1CO—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture