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BGC0001719PKS

Olimycin A;Olimycin B

Producing organism
Streptomyces olivaceus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
10
DOI
MIBiG entry
View on MIBiG ↗
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olimycin A
C31H35NO7533.24 Da

Gene Cluster Map35 genes · 74,495 bp

ERCALKSKSKSKSKSKSKSER10 kb74.5 kb visible · 74,495 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
DnDocking N-term
DcDocking C-term
CALCoA-ligase (CAL)
AmTAminotransferase I/II

Pathway Graphsteps arranged in biosynthetic order

10 steps · 9 edges
Step 1Load
QIE07123.1;QIE07124.1
+AHBA
Step 2M1
QIE07124.1;QIE07125.1
+Methylmalonyl-CoA
Inactive: DH
Step 3M2
QIE07126.1
+Malonyl-CoA
Step 4M3
QIE07126.1
+Malonyl-CoA
Inactive: KR
Step 5M4
QIE07127.1, QIE07117.1
+Ethylmalonyl-CoA
Step 6M5
QIE07128.1
+Malonyl-CoA
Step 7M6
QIE07129.1;QIE07130.1
+Isobutylmalonyl-C…
Step 8M7
QIE07131.1
+Methylmalonyl-CoA
Step 9M8
QIE07131.1
+Malonyl-CoA
Step 10
QIE07132.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions10 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11719-1QIE07123.1;QIE07124.1Loading
AHBA
OC1=CC(C(O)=O)=CC(N)=C1—
21719-2QIE07124.1;QIE07125.1M1
1719-1;Methylmalonyl-CoA
from: 1719-1
OC1=CC(C(O)C(C)C(O)=O)=CC(N)=C1{'Inactive': ['DH']}
31719-3QIE07126.1M2
1719-2;Malonyl-CoA
from: 1719-2
OC1=CC(C(O)C(C)C(CC(O)=O)=O)=CC(N)=C1—
41719-4QIE07126.1M3
1719-3;Malonyl-CoA
from: 1719-3
OC1=CC(C(O)C(C)C(CC(CC(O)=O)=O)=O)=CC(N)=C1{'Inactive': ['KR']}
51719-5QIE07127.1, QIE07117.1M4
1719-4;Ethylmalonyl-CoA
from: 1719-4
O=C(CC[C@@H](C(O)=O)CC)C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O—
61719-6QIE07128.1M5
1719-5;Malonyl-CoA
from: 1719-5
O=C(CC[C@@H](/C=C/C(O)=O)CC)C1=C(O)C(C)=CC(C(C(N)=C2)=O)=C1C2=O—
71719-7QIE07129.1;QIE07130.1M6
1719-6;Isobutylmalonyl-CoA
from: 1719-6
O=C(CC[C@@H](/C=C/CC(C(O)=O)CC(C)C)CC)C1=C(O)C(C)=CC(C(C(N)=C2)=O)=C1C2=O—
81719-8QIE07131.1M7
1719-7;Methylmalonyl-CoA
from: 1719-7
O=C(CC[C@@H](/C=C/CC(OC([C@@H](C(O)=O)C)=O)CC(C)C)CC)C1=C(O)C(C)=CC(C(C(N)=C2)=O)=C1C2=O—
91719-9QIE07131.1M8
1719-8;Malonyl-CoA
from: 1719-8
O=C(CC[C@@H](/C=C/CC(OC([C@@H](/C=C/C(O)=O)C)=O)CC(C)C)CC)C1=C(O)C(C)=CC(C(C(N)=C2)=O)=C1C2=O—
101719(1)QIE07132.1—
1719-9
from: 1719-9
O=C(N1)C=C[C@]2(C)C3=C1C(C4=C(C3=O)C(C(CC[C@@H](CC)/C=C/CC(CC(C)C)OC2=O)=O)=C(O)C(C)=C4)=O—
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