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BGC0001709PKS

nystatin

Producing organism
Streptomyces noursei
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
24
DOI
MIBiG entry
—
Loading…
nystatin
C47H75NO17925.50 Da

Pathway Graphsteps arranged in biosynthetic order

24 steps · 23 edges
Step 1Load
nysA
+Malonyl-CoA
Step 22
Start
+L-Fructose-6-phos…
Step 2M1
nysB
+Methylmalonyl-CoA
Step 23
nysDII,nysDIII, ?
Step 3M2
nysB
+Methylmalonyl-CoA
Step 4M3
nysC
+Malonyl-CoA
Step 5M4
nysC
+Malonyl-CoA
Step 6M5
nysC
+Malonyl-CoA
Step 7M6
nysC
+Malonyl-CoA
Step 8M7
nysC
+Malonyl-CoA
Step 9M8
nysC
+Malonyl-CoA
Step 10M9
nysI
+Malonyl-CoA
Step 11M10
nysI
+Malonyl-CoA
Step 12M11
nysI
+Methylmalonyl-CoA
Step 13M12
nysI
+Malonyl-CoA
Step 14M13
nysI
+Malonyl-CoA
Inactive: KR
Step 15M14
nysI
+Malonyl-CoA
Step 16M15
nysJ
+Malonyl-CoA
Step 17M16
nysJ
+Malonyl-CoA
Step 18M17
nysJ
+Malonyl-CoA
Inactive: DH
Step 19M18
nysK
+Malonyl-CoA
Inactive: DH
Step 20TE
nysK
Step 21
nysL,nysN
Step 24
nysDI
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions24 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11709-1nysALoading
Malonyl-CoA
OC(C)=O—
21709-2nysBM1
Methylmalonyl-CoA;1709-1
from: 1709-1
C[C@H](O)[C@H](C)C(O)=O—
31709-3nysBM2
Methylmalonyl-CoA;1709-2
from: 1709-2
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)C(O)=O—
41709-4nysCM3
Malonyl-CoA;1709-3
from: 1709-3
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C(O)=O—
51709-5nysCM4
Malonyl-CoA;1709-4
from: 1709-4
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/C(O)=O—
61709-6nysCM5
Malonyl-CoA;1709-5
from: 1709-5
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CCC(O)=O—
71709-7nysCM6
Malonyl-CoA;1709-6
from: 1709-6
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C(O)=O—
81709-8nysCM7
Malonyl-CoA;1709-7
from: 1709-7
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C(O)=O—
91709-9nysCM8
Malonyl-CoA;1709-8
from: 1709-8
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C(O)=O—
101709-10nysIM9
Malonyl-CoA;1709-9
from: 1709-9
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/C(O)=O—
111709-11nysIM10
Malonyl-CoA;1709-10
from: 1709-10
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O)CC(O)=O—
121709-12nysIM11
Methylmalonyl-CoA;1709-11
from: 1709-11
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O)C[C@@H](O)[C@@H](C)C(O)=O—
131709-13nysIM12
Malonyl-CoA;1709-12
from: 1709-12
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O)C[C@@H](O)[C@@H](C)[C@@H](O)CC(O)=O—
141709-14nysIM13
Malonyl-CoA;1709-13
from: 1709-13
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O)C[C@@H](O)[C@@H](C)[C@@H](O)CC(CC(O)=O)=O{'Inactive':['KR']}
151709-15nysIM14
Malonyl-CoA;1709-14
from: 1709-14
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O)C[C@@H](O)[C@@H](C)[C@@H](O)CC(C[C@H](O)CC(O)=O)=O—
161709-16nysJM15
Malonyl-CoA;1709-15
from: 1709-15
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O)C[C@@H](O)[C@@H](C)[C@@H](O)CC(C[C@H](O)CCCC(O)=O)=O—
171709-17nysJM16
Malonyl-CoA;1709-16
from: 1709-16
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O)C[C@@H](O)[C@@H](C)[C@@H](O)CC(C[C@H](O)CCC[C@H](O)CC(O)=O)=O—
181709-18nysJM17
Malonyl-CoA;1709-17
from: 1709-17
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O)C[C@@H](O)[C@@H](C)[C@@H](O)CC(C[C@H](O)CCC[C@H](O)C[C@H](O)CC(O)=O)=O{'Inactive':['DH']}
191709-19nysKM18
Malonyl-CoA;1709-18
from: 1709-18
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O)C[C@@H](O)[C@@H](C)[C@@H](O)CC(C[C@H](O)CCC[C@H](O)C[C@H](O)C[C@H](O)CC(O)=O)=O{'Inactive':['DH']}
201709-20nysKTE
1709-19
from: 1709-19
O[C@H](CC1[C@H](C)[C@@H](O)C[C@](C[C@@H](O)CCC[C@@H](O)C[C@@H](O)C[C@@H](O)CC(O[C@@H](C)[C@H](C)[C@@H]2O)=O)(O)O1)/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@@H]2C—
211709-21nysL,nysN—
1709-20
from: 1709-20
O[C@H](CC1[C@H](C(O)=O)[C@@H](O)C[C@](C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)C[C@@H](O)CC(O[C@@H](C)[C@H](C)[C@@H]2O)=O)(O)O1)/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@@H]2C—
221709-22Start—
L-Fructose-6-phosphate
O[C@@H]1[C@@](O)(CO)O[C@H](COP([O-])([O-])=O)[C@H]1O—
231709-23nysDII,nysDIII, ?—
1709-22
from: 1709-22
O[C@@H]1[C@@H](O)[C@@H](N)[C@H](O)[C@H](C)O1—
241709nysDI—
1709-21;1709-23
from: 1709-21, 1709-23
O[C@@H](C[C@](C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)C[C@@H](O)CC(O[C@@H](C)[C@H](C)[C@@H]1O)=O)(O)O2)[C@@H](C(O)=O)C2C[C@@H](O[C@@H]3[C@@H](O)[C@@H](N)[C@H](O)[C@H](C)O3)/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@@H]1C—
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