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BGC0001702Hybrid

Nocamycin

Producing organism
Saccharothrix syringae
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Saccharothrix
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
17
DOI
MIBiG entry
View on MIBiG ↗
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nocamycin
C26H33NO9503.22 Da

Gene Cluster Map27 genes · 68,204 bp

KSKSKSKSKSKSKSKSKS10 kb68.2 kb visible · 68,204 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

17 steps · 16 edges
Step 1Load
ARS01473.1
+Malonyl-CoA
Step 2M1
ARS01473.1
+Methylmalonyl-CoA
Step 3M2
ARS01473.1
+Methylmalonyl-CoA
Step 4M3
ARS01473.1
+Malonyl-CoA
Step 5M4
ARS01474.1
+Methylmalonyl-CoA
Inactive: DH
Step 6M5
ARS01475.1
+Methylmalonyl-CoA
Step 7M6
ARS01476.1
+Methylmalonyl-CoA
Step 8M7
ARS01477.1
+Malonyl-CoA
Step 9M8
ARS01477.1
+Malonyl-CoA
Step 10M9
ARS01470.1
+Glycine
Step 11
ARS01469.1
Step 12
ARS01478.1
Step 13
ARS01480.1
Step 14
ARS01480.1?/ARS01467.1?
Step 15
ARS01468.1
Step 16
ARS01480.1?/ARS01467.1?
Step 17
ARS01471.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions17 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11702-1ARS01473.1Loading
Malonyl-CoA
O=C(C)O—
21702-2ARS01473.1M1
1702-1;Methylmalonyl-CoA
from: 1702-1
OC(C(C)C(O)C)=O—
31702-3ARS01473.1M2
1702-2;Methylmalonyl-CoA
from: 1702-2
OC(C(C)C([C@@H](C(O)=O)C)=O)C—
41702-4ARS01473.1M3
1702-3;Malonyl-CoA
from: 1702-3
OC(C(C)C([C@@H]([C@H](CC(O)=O)O)C)=O)C—
51702-5ARS01474.1M4
1702-4;Methylmalonyl-CoA
from: 1702-4
OC(C(C)C([C@@H]([C@H](C[C@@H](O)[C@@H](C(O)=O)C)O)C)=O)C{'Inactive': ['DH']}
61702-6ARS01475.1M5
1702-5;Methylmalonyl-CoA
from: 1702-5
OC(C(C)C([C@@H]([C@H](C[C@@H](O)[C@@H]([C@@H](O)C(C(O)=O)C)C)O)C)=O)C—
71702-7ARS01476.1M6
1702-6;Methylmalonyl-CoA
from: 1702-6
OC(C(C)C([C@@H]([C@H](C[C@@H](O)[C@@H]([C@@H](O)C(/C=C(C)/C(O)=O)C)C)O)C)=O)C—
81702-8ARS01477.1M7
1702-7;Malonyl-CoA
from: 1702-7
OC(C(C)C([C@@H]([C@H](C[C@@H](O)[C@@H]([C@@H](O)C(/C=C(C)/C=C/C(O)=O)C)C)O)C)=O)C—
91702-9ARS01477.1M8
1702-8;Malonyl-CoA
from: 1702-8
OC(C(C)C([C@@H]([C@H](C[C@@H](O)[C@@H]([C@@H](O)C(/C=C(C)/C=C/C(CC(O)=O)=O)C)C)O)C)=O)C—
101702-10ARS01470.1M9
1702-9;Glycine
from: 1702-9
OC(C(C)C([C@@H]([C@H](C[C@@H](O)[C@@H]([C@@H](O)C(/C=C(C)/C=C/C(CC(NCC(O)=O)=O)=O)C)C)O)C)=O)C—
111702-11ARS01469.1—
1702-10
from: 1702-10
CC(/C=C/C(O)=C1C(CNC/1=O)=O)=C\[C@H]([C@@H]2[C@@H](C)[C@@H]3O[C@@]([C@@H](C)[C@H](O)C)([C@@H]([C@@H](O)C3)C)O2)C—
121702-12ARS01478.1—
1702-11
from: 1702-11
CC(/C=C/C(O)=C1C(CNC/1=O)=O)=C\[C@H]([C@@H]2[C@@H](C)[C@@H]3O[C@@]([C@@H](C)[C@H](O)C)(C(C)=CC3)O2)C—
131702-13ARS01480.1—
1702-12
from: 1702-12
CC(/C=C/C(O)=C1C(CNC/1=O)=O)=C\[C@H]([C@@H]2[C@@H](C)[C@@H]3O[C@@]([C@@H](C)[C@H](O4)C)([C@@]4(CC3)C)O2)C—
141702-14ARS01480.1?/ARS01467.1?—
1702-13
from: 1702-13
CC(/C=C/C(O)=C1C(CNC/1=O)=O)=C\[C@H]([C@@H]2[C@@H](C)[C@@H]3O[C@@]([C@@H](C(O)=O)[C@H](O4)C)([C@@]4(CC3)C)O2)C—
151702-15ARS01468.1—
1702-14
from: 1702-14
CC(/C=C/C(O)=C1C(CNC/1=O)=O)=C\[C@H]([C@@H]2[C@@H](C)[C@@H]3O[C@@]([C@@H](C(OC)=O)[C@H](O4)C)([C@@]4(CC3)C)O2)C—
161702-16ARS01480.1?/ARS01467.1?—
1702-15
from: 1702-15
CC(/C=C/C(O)=C1C(CNC/1=O)=O)=C\[C@H]([C@@H]2[C@@H](C)[C@@H]3O[C@@]([C@@H](C(OC)=O)[C@H](O4)C)([C@@]4(C[C@H]3O)C)O2)C—
171702ARS01471.1—
1702-16
from: 1702-16
CC(/C=C/C(O)=C1C(CNC/1=O)=O)=C\[C@H]([C@@H]2[C@@H](C)[C@@H]3O[C@@]([C@@H](C(OC)=O)[C@H](O4)C)([C@@]4(CC3=O)C)O2)C—
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