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BGC0001695NRPS

Neoantimycin

Producing organism
Streptomyces conglobatus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
18
DOI
MIBiG entry
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neoantimycin
C36H46N2O12698.31 Da

Gene Cluster Map17 genes · 41,200 bp

CACCALCCALKSATMTCCALTETEAAmT10 kb41.2 kb visible · 41,200 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
MTMethyltransferase
CALCoA-ligase (CAL)
AmTAminotransferase V

Pathway Graphsteps arranged in biosynthetic order

18 steps · 17 edges
Step 1
Start
+Tryptophan
Step 2
natN
Step 3
natQ, natO?
Step 4
natF;natG
Step 5
natH, natI, natJ, natK,…
Step 6
?
Step 7
natO
Step 8M1
natB
+Threonine
Step 9M2
natB
+2-oxo-3-methylbut…
Step 10M3
natB
+phenylpyruvic acid
Step 11M4
natC
+Dimethylmalonyl-C…
Step 12M5
natD
+(2-oxo-3-methylpe…
Step 13TE
natD
Step 14TE
natD
Step 15TE
natD
Step 16
natE
Step 17
natE
Step 18
natE
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions18 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11695-1Start—
Tryptophan
NC(C(O)=O)CC1=CNC2=CC=CC=C21—
21695-2natN—
1695-1
from: 1695-1
O=C(CC(C(O)=O)N)C1=CC=CC=C1NC([H])=O—
31695-3natQ, natO?—
1695-2
from: 1695-2
OC(C1=CC=CC=C1N)=O—
41695-4natF;natG—
1695-3
from: 1695-3
O=C(O)C1=CC=CC=C1N—
51695-5natH, natI, natJ, natK, natL—
1695-4
from: 1695-4
O=C(O)C12C(N)=CC=CC1O2—
61695-6?—
1695-5
from: 1695-5
O=C(O)C1=CC=CC(N)=C1O—
71695-7natO—
1695-6
from: 1695-6
O=C(O)C1=CC=CC(NC([H])=O)=C1O—
81695-8natBM1
1695-7;Threonine
from: 1695-7
[H]C(NC1=C(C(C(N[C@H](C(O)=O)[C@H](O)C)=O)=CC=C1)O)=O—
91695-9natBM2
1695-8;2-oxo-3-methylbutanoic acid
from: 1695-8
[H]C(NC1=C(C(C(N[C@H](C(O[C@H](C(O)=O)C(C)C)=O)[C@H](O)C)=O)=CC=C1)O)=O—
101695-10natBM3
1695-9;phenylpyruvic acid
from: 1695-9
[H]C(NC1=C(C(C(N[C@H](C(O[C@H](CO[C@@H](C(O)=O)CC2=CC=CC=C2)C(C)C)=O)[C@H](O)C)=O)=CC=C1)O)=O—
111695-11natCM4
1695-10;Dimethylmalonyl-CoA
from: 1695-10
[H]C(NC1=C(C(C(N[C@H](C(O[C@H](CO[C@@H](C(C(C)(C)C(O)=O)=O)CC2=CC=CC=C2)C(C)C)=O)[C@H](O)C)=O)=CC=C1)O)=O—
121695-12natDM5
1695-11;(2-oxo-3-methylpentanoic acid/2-oxo-3-methylbutanoic)
from: 1695-11
[H]C(NC1=C(C(C(N[C@H](C(O[C@H](CO[C@@H](C(C(C)(C)C(O[C@H](C(O)=O)[C@@H](C)C[R])=O)=O)CC2=CC=CC=C2)C(C)C)=O)[C@H](O)C)=O)=CC=C1)O)=O—
131695-13natDTE
1695-12
from: 1695-12
[H]C(NC1=C(C(C(N[C@H](C(O[C@H]2C(C)C)=O)[C@H](OC([C@@H](OC(C(C)(C)C([C@@H](CC3=CC=CC=C3)OC2=O)=O)=O)[C@H](C[R])C)=O)C)=O)=CC=C1)O)=O—
141695(1)natDTE
1695-12
from: 1695-12
[H]C(NC1=C(C(C(N[C@H](C(O[C@H]2C(C)C)=O)[C@H](OC([C@@H](OC(C(C)(C)C([C@@H](CC3=CC=CC=C3)OC2=O)=O)=O)[C@H](CC)C)=O)C)=O)=CC=C1)O)=O—
151695(2)natDTE
1695-12
from: 1695-12
[H]C(NC1=C(C(C(N[C@H](C(O[C@H]2C(C)C)=O)[C@H](OC([C@@H](OC(C(C)(C)C([C@@H](CC3=CC=CC=C3)OC2=O)=O)=O)C(C[H])C)=O)C)=O)=CC=C1)O)=O—
161695-14natE—
1695-13
from: 1695-13
[H]C(NC1=C(C(C(N[C@H](C(O[C@H]2C(C)C)=O)[C@H](OC([C@@H](OC(C(C)(C)[C@@H](O)[C@@H](CC3=CC=CC=C3)OC2=O)=O)[C@H](C[R])C)=O)C)=O)=CC=C1)O)=O—
171695(3)natE—
1695-13
from: 1695-13
[H]C(NC1=C(C(C(N[C@H](C(O[C@H]2C(C)C)=O)[C@H](OC([C@@H](OC(C(C)(C)[C@@H](O)[C@@H](CC3=CC=CC=C3)OC2=O)=O)[C@H](CC)C)=O)C)=O)=CC=C1)O)=O—
181695(4)natE—
1695-13
from: 1695-13
[H]C(NC1=C(C(C(N[C@H](C(O[C@H]2C(C)C)=O)[C@H](OC([C@@H](OC(C(C)(C)[C@@H](O)[C@@H](CC3=CC=CC=C3)OC2=O)=O)C(C[H])C)=O)C)=O)=CC=C1)O)=O—
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