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BGC0001694PKS

Neoabyssomicin B;Abyssomicin 2;Abyssomicin 4

Producing organism
Streptomyces koyangensis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces›Streptomyces aurantiacus group
Biosynthetic class
PKS (Unknown)
Total steps
18
DOI
MIBiG entry
View on MIBiG ↗
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C19H22O7362.14 Da

Gene Cluster Map32 genes · 73,870 bp

KSKSKSKSKSKSKS10 kb73.9 kb visible · 73,870 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
FkFkbH-like
ACPSACP synthase

Pathway Graphsteps arranged in biosynthetic order

18 steps · 17 edges
Step 1M1
AVI57433.1
+Malonyl-CoA
Step 8
Start
Step 2M2
AVI57433.1
+Methylmalonyl-CoA
Step 9
AVI57427.1;AVI57428.1
Step 3M3
AVI57433.1
+Malonyl-CoA
Step 4M4
AVI57433.1
+Malonyl-CoA
Step 5M5
AVI57434.1
+Methylmalonyl-CoA
Inactive: KR
Step 6M6
AVI57434.1
+Malonyl-CoA
Step 7M7
AVI57435.1
+Malonyl-CoA
Step 10
AVI57426.1
Step 11
AVI57426.1
Step 12
AVI57429.1
Step 13
AVI57430.1
Step 14
AVI57412.1
Step 15
?
Step 16
?
Step 17
?
+1694(1)
Step 18
?
+1694(1)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions18 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11694-1AVI57433.1M1
Malonyl-CoA
O=C(C)O—
21694-2AVI57433.1M2
1694-1;Methylmalonyl-CoA
from: 1694-1
C/C=C(C)/C(O)=O—
31694-3AVI57433.1M3
1694-2;Malonyl-CoA
from: 1694-2
C/C=C(C)/C=C/C(O)=O—
41694-4AVI57433.1M4
1694-3;Malonyl-CoA
from: 1694-3
C/C=C(C)/C=C/C=C/C(O)=O—
51694-5AVI57434.1M5
1694-4;Methylmalonyl-CoA
from: 1694-4
C/C=C(C)/C=C/C=C/C([C@@H](C)C(O)=O)=O{'Inactive': ['KR']}
61694-6AVI57434.1M6
1694-5;Malonyl-CoA
from: 1694-5
C/C=C(C)/C=C/C=C/C([C@@H](C)CCC(O)=O)=O—
71694-7AVI57435.1M7
1694-6;Malonyl-CoA
from: 1694-6
C/C=C(C)/C=C/C=C/C([C@@H](C)CCC(CC(O)=O)=O)=O—
81694-8Start—
[O-]C(C(OP(O)(O)=O)=O)COP(O)([O-])=O—
91694-9AVI57427.1;AVI57428.1—
1694-8
from: 1694-8
[O-]C(C(O)=O)CO—
101694-10AVI57426.1—
1694-7;1694-9
from: 1694-7, 1694-9
C/C=C(C)/C=C/C=C/C([C@@H](C)CCC([CH-]C(OC(CO)C(O)=O)=O)=O)=O—
111694-11AVI57426.1—
1694-10
from: 1694-10
C/C=C(C)/C=C/C=C/C([C@@H](C)CCC(C1=C(O)C(CO)OC1=O)=O)=O—
121694-12AVI57429.1—
1694-11
from: 1694-11
C/C=C(C)/C=C/C=C/C([C@@H](C)CCC(C1=C(O)C(COC(C)=O)OC1=O)=O)=O—
131694-13AVI57430.1—
1694-12
from: 1694-12
C/C=C(C)/C=C/C=C/C([C@@H](C)CCC(C1=C(O)C(OC1=O)=C)=O)=O—
141694-14AVI57412.1—
1694-13
from: 1694-13
O=C(CC[C@H](C)C(/C=C/C1C=C(C)[C@@H](C)C2)=O)C3=C(O)[C@@]12OC3=O—
151694-15?—
1694-14
from: 1694-14
O=C(CC[C@H](C)C(/C=C/C1[C@H]2[C@@](O2)(C)[C@@H](C)C3)=O)C4=C(O)[C@@]13OC4=O—
161694(1)?—
1694-15
from: 1694-15
O=C(CC[C@H](C)C(/C=C/C1[C@H](O)[C@]2(C)[C@@H](C)C3)=O)C4=C(O2)[C@@]13OC4=O—
171694(2)?—
1694(1)
O=C(CC[C@H](C)C(C[C@@H](O)C1[C@H](O)[C@]2(C)[C@@H](C)C3)=O)C4=C(O2)[C@@]13OC4=O—
181694(3)?—
1694(1)
O=C(CC[C@@H](O1)C)C2=C(O3)[C@]4([C@](/C=C/C1=O)([H])[C@H](O)[C@]3(C)[C@@H](C)C4)OC2=O—
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