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BGC0001670PKS

Monensin

Producing organism
Streptomyces virginiae
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
16
DOI
MIBiG entry
—
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monensin
C36H62O11670.43 Da

Pathway Graphsteps arranged in biosynthetic order

16 steps · 15 edges
Step 1Load
monAI
+Malonyl-CoA
Step 2M1
monAI
+Methylmalonyl-CoA
Step 3M2
monAII
+Methylmalonyl-CoA
Step 4M3
monAIII
+Malonyl-CoA
Step 5M4
monAIII
+Methylmalonyl-CoA
Step 6M5
monAIV
+Ethylmalonyl-CoA
Step 7M6
monAIV
+Malonyl-CoA
Step 8M7
monAV
+Methylmalonyl-CoA
Step 9M8
monAVI
+Malonyl-CoA
Step 10M9
monAVII
+Malonyl-CoA
Step 11M10
monAVII
+Methylmalonyl-CoA
Step 12M11
monAVIII
+Methylmalonyl-CoA
Step 13M12
monAVIII
+Methylmalonyl-CoA
Step 14
monCI
Step 15
monBI;monBII
Step 16
monD, monE, monCII
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions16 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11670-1monAILoading
Malonyl-CoA
O=C(O)C—
21670-2monAIM1
1670-1;Methylmalonyl-CoA
from: 1670-1
O=C([C@H](C)C(O)=O)C—
31670-3monAIIM2
1670-2;Methylmalonyl-CoA
from: 1670-2
O=C([C@H](C)C[C@H](C)C(O)=O)C—
41670-4monAIIIM3
1670-3;Malonyl-CoA
from: 1670-3
O=C([C@H](C)C[C@H](C)/C=C/C(O)=O)C—
51670-5monAIIIM4
1670-4;Methylmalonyl-CoA
from: 1670-4
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)C(O)=O)C—
61670-6monAIVM5
1670-5;Ethylmalonyl-CoA
from: 1670-5
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)/C=C(CC)/C(O)=O)C—
71670-7monAIVM6
1670-6;Malonyl-CoA
from: 1670-6
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)/C=C(CC)/CCC(O)=O)C—
81670-8monAVM7
1670-7;Methylmalonyl-CoA
from: 1670-7
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)/C=C(CC)/CC/C=C(C)/C(O)=O)C—
91670-9monAVIM8
1670-8;Malonyl-CoA
from: 1670-8
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)/C=C(CC)/CC/C=C(C)/CCC(O)=O)C—
101670-10monAVIIM9
1670-9;Malonyl-CoA
from: 1670-9
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)/C=C(CC)/CC/C=C(C)/CCC(CC(O)=O)=O)C—
111670-11monAVIIM10
1670-10;Methylmalonyl-CoA
from: 1670-10
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)/C=C(CC)/CC/C=C(C)/CCC(C[C@H](O)[C@@H](C)C(O)=O)=O)C—
121670-12monAVIIIM11
1670-11;Methylmalonyl-CoA
from: 1670-11
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)/C=C(CC)/CC/C=C(C)/CCC(C[C@H](O)[C@@H](C)[C@H](O)[C@H](C(O)=O)C)=O)C—
131670-13monAVIIIM12
1670-12;Methylmalonyl-CoA
from: 1670-12
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)/C=C(CC)/CC/C=C(C)/CCC(C[C@H](O)[C@@H](C)[C@H](O)[C@H]([C@@H](O)[C@@H](C(O)=O)C)C)=O)C—
141670-14monCI—
1670-13
from: 1670-13
O=C([C@H](C)C[C@H](C)[C@H]1[C@@H](O1)C[C@H](C)[C@@H]2[C@](CC)(O2)CC[C@@H]3[C@](C)(O3)CCC(C[C@H](O)[C@@H](C)[C@H](O)[C@H]([C@@H](O)[C@@H](C(O)=O)C)C)=O)C—
151670-15monBI;monBII—
1670-14
from: 1670-14
C[C@@H]([C@@H](O)[C@@H](C(O)=O)C)[C@H]1O[C@]2(O[C@@]([C@@H]3O[C@@]([C@@H]4O[C@@H]([C@H]5O[C@@](O)(C)[C@H](C)C[C@@H]5C)C[C@@H]4C)(CC)CC3)(C)CC2)C[C@H](O)[C@H]1C—
161670monD, monE, monCII—
1670-15
from: 1670-15
C[C@@H]([C@@H](OC)[C@@H](C(O)=O)C)[C@H]1O[C@]2(O[C@@]([C@@H]3O[C@@]([C@@H]4O[C@@H]([C@H]5O[C@@](O)(CO)[C@H](C)C[C@@H]5C)C[C@@H]4C)(CC)CC3)(C)CC2)C[C@H](O)[C@H]1C—
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