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BGC0001666PKS

Microansamycin A;Microansamycin B;Microansamycin C;Microansamycin D;Microansamycin E;Microansamycin F;Microansamycin G;Microansamycin H;Microansamycin I

Producing organism
Micromonospora sp. HK160111
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Micromonosporales›Micromonosporaceae›Micromonospora
Biosynthetic class
PKS (Unknown)
Total steps
19
DOI
MIBiG entry
View on MIBiG ↗
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C17H21NO5319.36 Da

Gene Cluster Map27 genes · 69,750 bp

CALKSKSKSKS10 kb69.7 kb visible · 69,750 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
CALCoA-ligase (CAL)
AmTAminotransferase I/II

Pathway Graphsteps arranged in biosynthetic order

19 steps · 18 edges
Step 1Load
mas4
+AHBA
Step 2M1
mas4
+Malonyl-CoA
Step 3M2
mas4
+Malonyl-CoA
Step 4M3
mas12
+Methylmalonyl-CoA
Step 5M4
mas11
+Methylmalonyl-CoA
Step 6
mas10
Step 7
?
Step 8
mas9
Step 9
?
Step 15
?
Step 10
?
Step 11
?
Step 12
Step 14
?
Step 16
?
Step 13
?
Step 17
?
+1666(5)
Step 18
?
+1666(5)
Step 19
?
+1666(5)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions19 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11666-1mas4Loading
AHBA
OC1=CC(N)=CC(C(O)=O)=C1—
21666-2mas4M1
1666-1;Malonyl-CoA
from: 1666-1
OC1=CC(N)=CC(CCC(O)=O)=C1—
31666-3mas4M2
1666-2;Malonyl-CoA
from: 1666-2
OC1=CC(N)=CC(CC/C=C/C(O)=O)=C1—
41666-4mas12M3
1666-3;Methylmalonyl-CoA
from: 1666-3
OC1=CC(N)=CC(CC/C=C/C=C(C(O)=O)\C)=C1—
51666-5mas11M4
1666-4;Methylmalonyl-CoA
from: 1666-4
OC1=CC(N)=CC(CC/C=C/C=C(C(C(C(O)=O)C)=O)\C)=C1—
61666-6mas10—
1666-5
from: 1666-5
C/C(C(C(C)C(N1)=O)=O)=C\C=C\CCC2=CC(O)=CC1=C2—
71666(1)?—
1666-6
from: 1666-6
C/C(C(CC)=O)=C\C=C\CCC1=CC(O)=CC(NC(C)=O)=C1—
81666-7mas9—
1666-6
from: 1666-6
C/C(C(C(C)C(N1)=O)=O)=C\C=C\CCC2=CC(O)=CC1=C2O—
91666-8?—
1666-7
from: 1666-7
C/C(C([C@@H](C)C(N1)=O)=O)=C\C=C\CCC(C(C1=C2)=O)=CC2O—
101666(2)?—
1666-8
from: 1666-8
OC1C[C@@H](CC[C@@](O2)([H])[C@]2([H])C[C@H](C)C3=O)[C@@]([C@@]43C)(O)C(NC4=O)=C1—
111666(3)?—
1666-8
from: 1666-8
OC1C=C2[C@@]3([C@]4(C)C([C@H](C)C[C@@H](O3)[C@@H](O)CC2)=O)C(NC4=O)=C1—
121666-9—
1666-8
from: 1666-8
C/C(C([C@H](C)C(N1)=O)=O)=C\C=C\CCC(C(C1=C2)=O)=CC2O—
131666(4)?—
1666-9
from: 1666-9
OC1C[C@@H]2[C@]3([C@@]4(C)C([C@H](C[C@H](O)[C@H](O3)CC2)C)=O)C(NC4=O)=C1—
141666(5)?—
1666-7
from: 1666-7
C/C(C(C(C)C(N1)=O)=O)=C\C=C\CC[C@H](C[C@@H]2O)C(C1=C2)O—
151666-10?—
1666-7
from: 1666-7
C/C(C(C(C)C(N1)=O)=O)=C\[C@@H]2[C@@H](O2)CCC3=CC(O)=CC1=C3O—
161666(5)?—
1666-10
from: 1666-10
C/C(C(C(C)C(N1)=O)=O)=C\[C@@H]2[C@@H](O)CCC3=CC(O)=CC1=C3O2—
171666(6)?—
1666(5)
C[C@@H](C[C@@H]1[C@@H](O)CCC2=CC(O)=CC3=C2O1)C([C@H](C)C(N3)=O)=O—
181666(7)?—
1666(5)
C/C(C(CC)=O)=C\[C@@H]1[C@@H](O)CCC2=CC(O)=CC(NC(CO)=O)=C2O1—
191666(8)?—
1666(5)
C/C(C(O)=O)=C\[C@@H]1[C@@H](O)CCC2=CC(O)=CC(NC(CC)=O)=C2O1—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture