NPdia
← Back to Repository
BGC0001662PKS

Mediomycin A

Producing organism
Kitasatospora mediocidica
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Kitasatospora
Biosynthetic class
PKS (Unknown)
Total steps
32
DOI
MIBiG entry
View on MIBiG ↗
Loading…
mediomycin A
C62H97NO18S1175.64 Da

Gene Cluster Map25 genes · 161,503 bp

20 kb161.5 kb visible · 161,503 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

32 steps · 31 edges
Step 1
Start
Step 2
cleD, cleO, cleE
Step 3Load
cleG;cle1
Step 4M1
cle1
+Malonyl-CoA
Step 5M2
cle1
+Malonyl-CoA
Step 6M3
cle1
+Malonyl-CoA
Step 7M4
cle1
+Malonyl-CoA
Step 8M5
cle1
+Malonyl-CoA
Step 9M6
cle2
+Malonyl-CoA
Step 10M7
cle2
+Malonyl-CoA
Step 11M8
cle3
+Malonyl-CoA
Inactive: DH
Step 12M9
cle3
+Malonyl-CoA
Step 13M10
cle3
+Malonyl-CoA
Step 14M11
cle3
+Malonyl-CoA
Step 15M12
cle3
+Malonyl-CoA
Inactive: DH
Step 16M13
cle4
+Methylmalonyl-CoA
Inactive: KR
Step 17M14
cle5, ?
+Malonyl-CoA
Step 18M15
cle5
+Malonyl-CoA
Step 19M16
cle5
+Malonyl-CoA
Step 20M17
cle6
+Malonyl-CoA
Step 21M18
cle6
+Malonyl-CoA
Step 22M19
cle6
+Malonyl-CoA
Step 23M20
cle6
+Methylmalonyl-CoA
Step 24M21
cle7
+Methylmalonyl-CoA
Step 25M22
cle7
+Malonyl-CoA
Step 26M23
cle8
+Malonyl-CoA
Step 27M24
cle8
+Malonyl-CoA
Step 28M25
cle8
+Malonyl-CoA
Step 29M26
cle9
+Methylmalonyl-CoA
Step 30M27
cle9
+Methylmalonyl-CoA
Step 31TE
cle9
Step 32
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions32 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11662-1Start—
N[C@@H](CCCNC(N)=N)C(O)=O—
21662-2cleD, cleO, cleE—
1662-1
from: 1662-1
O=C(CCCNC(N)=N)[R]—
31662-3cleG;cle1Loading
1662-2
from: 1662-2
OC(CCCNC(N)=N)=O—
41662-4cle1M1
1662-3;Malonyl-CoA
from: 1662-3
OC(C[C@H](O)CCCNC(N)=N)=O—
51662-5cle1M2
1662-4;Malonyl-CoA
from: 1662-4
NC(NCCC[C@@H](O)C[C@@H](O)CC(O)=O)=N—
61662-6cle1M3
1662-5;Malonyl-CoA
from: 1662-5
OC(/C=C/C[C@H](O)C[C@H](O)CCCNC(N)=N)=O—
71662-7cle1M4
1662-6;Malonyl-CoA
from: 1662-6
OC(C[C@H](O)/C=C/C[C@H](O)C[C@H](O)CCCNC(N)=N)=O—
81662-8cle1M5
1662-7;Malonyl-CoA
from: 1662-7
NC(NCCC[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)CC(O)=O)=N—
91662-9cle2M6
1662-8;Malonyl-CoA
from: 1662-8
OC(/C=C/C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)CCCNC(N)=N)=O—
101662-10cle2M7
1662-9;Malonyl-CoA
from: 1662-9
OC(C[C@@H](O)/C=C/C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)CCCNC(N)=N)=O—
111662-11cle3M8
1662-10;Malonyl-CoA
from: 1662-10
OC(C[C@H](O)C[C@@H](O)/C=C/C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)CCCNC(N)=N)=O{'Inactive': ['DH']}
121662-12cle3M9
1662-11;Malonyl-CoA
from: 1662-11
NC(NCCC[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C/C=C/[C@H](O)C[C@@H](O)C[C@@H](O)CC(O)=O)=N—
131662-13cle3M10
1662-12;Malonyl-CoA
from: 1662-12
OC(/C=C/C[C@H](O)C[C@H](O)C[C@@H](O)/C=C/C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)CCCNC(N)=N)=O—
141662-14cle3M11
1662-13;Malonyl-CoA
from: 1662-13
OC(C[C@H](O)/C=C/C[C@H](O)C[C@H](O)C[C@@H](O)/C=C/C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)CCCNC(N)=N)=O—
151662-15cle3M12
1662-14;Malonyl-CoA
from: 1662-14
OC(C[C@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)C[C@@H](O)/C=C/C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)CCCNC(N)=N)=O{'Inactive': ['DH']}
161662-16cle4M13
1662-15;Methylmalonyl-CoA
from: 1662-15
OC([C@@H](C)C(C[C@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)C[C@@H](O)/C=C/C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)CCCNC(N)=N)=O)=O{'Inactive': ['KR']}
171662-17cle5, ?M14
1662-16;Malonyl-CoA
from: 1662-16
NC(NCCC[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C/C=C/[C@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](OS(=O)(O)=O)CC(O)=O)=O)=N—
181662-18cle5M15
1662-17;Malonyl-CoA
from: 1662-17
NC(NCCC[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C/C=C/[C@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](OS(=O)(O)=O)C/C=C/C(O)=O)=O)=N—
191662-19cle5M16
1662-18;Malonyl-CoA
from: 1662-18
NC(NCCC[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C/C=C/[C@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](OS(=O)(O)=O)C/C=C/C=C/C(O)=O)=O)=N—
201662-20cle6M17
1662-19;Malonyl-CoA
from: 1662-19
NC(NCCC[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C/C=C/[C@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](OS(=O)(O)=O)C/C=C/C=C/C=C/C(O)=O)=O)=N—
211662-21cle6M18
1662-20;Malonyl-CoA
from: 1662-20
NC(NCCC[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C/C=C/[C@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](OS(=O)(O)=O)C/C=C/C=C/C=C/C=C/C(O)=O)=O)=N—
221662-22cle6M19
1662-21;Malonyl-CoA
from: 1662-21
NC(NCCC[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C/C=C/[C@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](OS(=O)(O)=O)C/C=C/C=C/C=C/C=C/C=C/C(O)=O)=O)=N—
231662-23cle6M20
1662-22;Methylmalonyl-CoA
from: 1662-22
OC(/C=C/C=C/C=C/C=C/C=C/C=C/C[C@H](OS(=O)(O)=O)[C@@H](C)C(C[C@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)C[C@@H](O)/C=C/C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)CCCNC(N)=N)=O)=O—
241662-24cle7M21
1662-23;Methylmalonyl-CoA
from: 1662-23
OC([C@@H](C)[C@H](O)/C=C/C=C/C=C/C=C/C=C/C=C/C[C@H](OS(=O)(O)=O)[C@@H](C)C(C[C@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)C[C@@H](O)/C=C/C[C@@H](O)C[C@H](O)/C=C/C[C@H](O)C[C@H](O)CCCNC(N)=N)=O)=O—
251662-25cle7M22
1662-24;Malonyl-CoA
from: 1662-24
NC(NCCC[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C/C=C/[C@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](OS(=O)(O)=O)C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)C(O)=O)=O)=N—
261662-26cle8M23
1662-25;Malonyl-CoA
from: 1662-25
NC(NCCC[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C/C=C/[C@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](OS(=O)(O)=O)C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/C(O)=O)=O)=N—
271662-27cle8M24
1662-26;Malonyl-CoA
from: 1662-26
NC(NCCC[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C/C=C/[C@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](OS(=O)(O)=O)C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/CCC(O)=O)=O)=N—
281662-28cle8M25
1662-27;Malonyl-CoA
from: 1662-27
NC(NCCC[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C/C=C/[C@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](OS(=O)(O)=O)C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/CC/C=C/C(O)=O)=O)=N—
291662-29cle9M26
1662-28;Methylmalonyl-CoA
from: 1662-28
NC(NCCC[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C/C=C/[C@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](OS(=O)(O)=O)C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/CC/C=C/C=C/C(O)=O)=O)=N—
301662-30cle9M27
1662-29;Methylmalonyl-CoA
from: 1662-29
NC(NCCC[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C/C=C/[C@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](OS(=O)(O)=O)C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/CC/C=C/C=C/C=C(C)/C(O)=O)=O)=N—
311662-31cle9TE
1662-30
from: 1662-30
NC(NCCC[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C/C=C/[C@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](OS(=O)(O)=O)C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/CC/C=C/C=C/C=C(C)/C(O)=O)=O)=N—
321662?—
1662-31
from: 1662-31
NCCC[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@H](O)C/C=C/[C@H](O)C[C@@H](O)C[C@@H](O)C/C=C/[C@@H](O)C[C@@H](O)CC([C@H](C)[C@@H](OS(=O)(O)=O)C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/CC/C=C/C=C/C=C(C)/C(O)=O)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture