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BGC0001658PKS

Macrotermycins

Producing organism
Amycolatopsis sp. M39
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Amycolatopsis
Biosynthetic class
PKS (Unknown)
Total steps
11
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map26 genes · 53,529 bp

AAKSKSKSATKSATKSATKSATKSAT10 kb53.5 kb visible · 53,529 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

11 steps · 10 edges
Step 1Load
?
Step 2M1
?
+Malonyl-CoA
Step 3M2
?
+Malonyl-CoA
Step 4M3
?
+Malonyl-CoA
Step 5M4
A4R44_03187;A4R44_03188
+Malonyl-CoA
Step 6M5
A4R44_03195
+Malonyl-CoA
Step 7M6
A4R44_03196
+Methylmalonyl-CoA
Step 8M7
A4R44_03197
+Malonyl-CoA
Step 9M8
A4R44_03197
+Malonyl-CoA
Step 10TE
A4R44_03191
Step 11
A4R44_03186, ?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions11 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11658-1?Loading
CC(C(O)=O)NC(C(N)C)=O—
21658-2?M1
1658-1;Malonyl-CoA
from: 1658-1
O=C(C(N)C)NC(C)/C=C\C(O)=O—
31658-3?M2
1658-2;Malonyl-CoA
from: 1658-2
O=C(C(N)C)NC(C)/C=C\C=C\C(O)=O—
41658-4?M3
1658-3;Malonyl-CoA
from: 1658-3
CC(/C=C\C=C\C=C/C(O)=O)NC(C(C)N)=O—
51658-5A4R44_03187;A4R44_03188M4
1658-4;Malonyl-CoA
from: 1658-4
CC(/C=C\C=C\C=C/C=C/C(O)=O)NC(C(C)N)=O—
61658-6A4R44_03195M5
1658-5;Malonyl-CoA
from: 1658-5
O=C(C(N)C)NC(C)/C=C\C=C\C=C/C=C/C=C\C(O)=O—
71658-7A4R44_03196M6
1658-6;Methylmalonyl-CoA
from: 1658-6
O=C(C(N)C)NC(C)/C=C\C=C\C=C/C=C/C=C\[C@H](O)[C@H](C(O)=O)C—
81658-8A4R44_03197M7
1658-7;Malonyl-CoA
from: 1658-7
O=C(C(N)C)NC(C)/C=C\C=C\C=C/C=C/C=C\[C@H](O)[C@H](/C=C/C(O)=O)C—
91658-9A4R44_03197M8
1658-8;Malonyl-CoA
from: 1658-8
O=C(C(N)C)NC(C)/C=C\C=C\C=C/C=C/C=C\[C@H](O)[C@H](/C=C/C=C/C(O)=O)C—
101658-10A4R44_03191TE
1658-9
from: 1658-9
O[C@@H]1[C@@H](C)/C=C/C=C/C(NCC(C)/C=C\C=C\C=C/C=C/C=C\1)=O—
111658A4R44_03186, ?—
1658-10
from: 1658-10
O[C@@H]1[C@@](C)(O)/C=C/C=C/C(NCC(C)/C=C\C=C\C=C/C=C/C=C\1)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture