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BGC0001648PKS

Lasalocid

Producing organism
Streptomyces sp
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
13
DOI
MIBiG entry
View on MIBiG ↗
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lasalocid
C34H54O8590.38 Da

Gene Cluster Map22 genes · 76,167 bp

ERKSKSKSKSKSKSKSKSKSKSKSKS20 kb76.2 kb visible · 76,167 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
CycPolyketide cyclase

Pathway Graphsteps arranged in biosynthetic order

13 steps · 12 edges
Step 1M1
ANR02549.1
+Malonyl-CoA
Step 2M2
ANR02549.1;ANR02550.1
+Ethylmalonyl-CoA
{'Missing': ['AT', 'DH']}
Step 3M3
ANR02551.1;ANR02547.1?
+Malonyl-CoA
{'Missing': ['KR', 'DH', '…
Step 4M4
ANR02552.1
+Ethylmalonyl-CoA
{'Missing': ['DH']}
Step 5M5
ANR02553.1
+Methylmalonyl-CoA
Step 6M6
ANR02553.1;ANR02554.1
+Ethylmalonyl-CoA
Step 7M7
ANR02554.1
+Methylmalonyl-CoA
Inactive: DH, ER
Step 8M8
ANR02555.1
+Methylmalonyl-CoA
Step 9M9
ANR02555.1
+Malonyl-CoA
Step 10M10
ANR02555.1
+Malonyl-CoA
Inactive: KR
Step 11M11
ANR02556.1
+Methylmalonyl-CoA
Step 12M12
ANR02557.1
+Malonyl-CoA
Step 13TE
ANR02557.1, ?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions13 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11648-1ANR02549.1M1
Malonyl-CoA
O=C(C)O—
21648-2ANR02549.1;ANR02550.1M2
1648-1;Ethylmalonyl-CoA
from: 1648-1
C/C=C(C(O)=O)\CC{'Missing': ['AT', 'DH']}
31648-3ANR02551.1;ANR02547.1?M3
1648-2;Malonyl-CoA
from: 1648-2
C/C=C(CCC(O)=C)\CC{'Missing': ['KR', 'DH', 'ER…
41648-4ANR02552.1M4
1648-3;Ethylmalonyl-CoA
from: 1648-3
C/C=C(CC/C=C(C(O)=O)\CC)\CC{'Missing': ['DH']}
51648-5ANR02553.1M5
1648-4;Methylmalonyl-CoA
from: 1648-4
C/C=C(CC/C=C(C[C@@H](C(O)=O)C)\CC)\CC—
61648-6ANR02553.1;ANR02554.1M6
1648-5;Ethylmalonyl-CoA
from: 1648-5
C/C=C(CC/C=C(C[C@@H]([C@H](O)[C@H](C(O)=O)CC)C)\CC)\CC—
71648-7ANR02554.1M7
1648-6;Methylmalonyl-CoA
from: 1648-6
C/C=C(CC/C=C(C[C@@H]([C@H](O)[C@H](C([C@H](C(O)=O)C)=O)CC)C)\CC)\CC{'Inactive': ['DH', 'ER']}
81648-8ANR02555.1M8
1648-7;Methylmalonyl-CoA
from: 1648-7
C/C=C(CC/C=C(C[C@@H]([C@H](O)[C@H](C([C@H]([C@@H](O)[C@@H](C(O)=O)C)C)=O)CC)C)\CC)\CC—
91648-9ANR02555.1M9
1648-8;Malonyl-CoA
from: 1648-8
C/C=C(CC/C=C(C[C@@H]([C@H](O)[C@H](C([C@H]([C@@H](O)[C@@H](CCC(O)=O)C)C)=O)CC)C)\CC)\CC—
101648-10ANR02555.1M10
1648-9;Malonyl-CoA
from: 1648-9
C/C=C(CC/C=C(C[C@@H]([C@H](O)[C@H](C([C@H]([C@@H](O)[C@@H](CCC(CC(O)=O)=O)C)C)=O)CC)C)\CC)\CC{'Inactive': ['KR']}
111648-11ANR02556.1M11
1648-10;Methylmalonyl-CoA
from: 1648-10
O=C(CC[C@H]([C@@H]([C@@H](C([C@@H]([C@H]([C@H](C/C(CC)=C/CC/C(CC)=C/C)C)O)CC)=O)C)O)C)C/C=C(C)\C(O)=O—
121648-12ANR02557.1M12
1648-11;Malonyl-CoA
from: 1648-11
O=C(CC[C@H]([C@@H]([C@@H](C([C@@H]([C@H]([C@H](C/C(CC)=C/CC/C(CC)=C/C)C)O)CC)=O)C)O)C)C/C=C(C)\C(CC(O)=O)=O—
131648ANR02557.1, ?TE
1648-12
from: 1648-12
C[C@@H]([C@@H]([C@@H](C([C@@H]([C@H]1O[C@@]([C@@H]2O[C@@H](C)[C@](CC)(O)CC2)(CC)C[C@@H]1C)CC)=O)C)O)CCC3=C(C(O)=O)C(O)=C(C)C=C3—
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