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BGC0001635Hybrid

Kistamicin A

Producing organism
Nonomuraea sp. ATCC 55076
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Streptosporangiales›Streptosporangiaceae›Nonomuraea
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
8
DOI
MIBiG entry
View on MIBiG ↗
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kistamicin A
C61H51ClN8O151170.32 Da

Gene Cluster Map25 genes · 49,434 bp

CAECAECACAECACAXAmTECH10 kb49.4 kb visible · 49,434 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
CnCOM N-term
TEThioesterase (TE)
EEpimerization (E)
ECHEnoyl-CoA hydratase
AmTAminotransferase I/II
XPutative domain (X)
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

8 steps · 7 edges
Step 1M1
BKM31_54135
+Tyrosine
Step 2M2
BKM31_54135
+Tryptophan
Step 3M3
BKM31_54140
+3,5-dihydroxyphen…
Step 4M4
BKM31_54145
+4-hydroxphenylgly…
Step 5M5
BKM31_54145
+4-hydroxphenylgly…
Step 6M6
BKM31_54145
+Tyrosine
Step 7M7
BKM31_54150
+4-hydroxphenylgly…
Step 8TE
BKM31_54150, (BKM31_541…
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions8 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11635-1BKM31_54135M1
Tyrosine
OC([C@H](N)CC1=CC=C(O)C=C1)=O—
21635-2BKM31_54135M2
1635-1;Tryptophan
from: 1635-1
OC([C@H](NC([C@H](N)CC1=CC=C(O)C=C1)=O)CC2=CNC3=C2C=CC=C3)=O—
31635-3BKM31_54140M3
1635-2;3,5-dihydroxyphenylglycine
from: 1635-2
OC([C@H](NC([C@H](NC([C@H](N)CC1=CC=C(O)C=C1)=O)CC2=CNC3=C2C=CC=C3)=O)C4=CC(O)=CC(O)=C4)=O—
41635-4BKM31_54145M4
1635-3;4-hydroxphenylglycine
from: 1635-3
OC([C@H](NC([C@H](NC([C@H](NC([C@H](N)CC1=CC=C(O)C=C1)=O)CC2=CNC3=C2C=CC=C3)=O)C4=CC(O)=CC(O)=C4)=O)C5=CC=C(O)C=C5)=O—
51635-5BKM31_54145M5
1635-4;4-hydroxphenylglycine
from: 1635-4
OC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](N)CC1=CC=C(O)C=C1)=O)CC2=CNC3=C2C=CC=C3)=O)C4=CC(O)=CC(O)=C4)=O)C5=CC=C(O)C=C5)=O)C6=CC=C(O)C=C6)=O—
61635-6BKM31_54145M6
1635-5;Tyrosine
from: 1635-5
OC([C@@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](N)CC1=CC=C(O)C=C1)=O)CC2=CNC3=C2C=CC=C3)=O)C4=CC(O)=CC(O)=C4)=O)C5=CC=C(O)C=C5)=O)C6=CC=C(O)C=C6)=O)CC7=CC=C(O)C=C7)=O—
71635-7BKM31_54150M7
1635-6;4-hydroxphenylglycine
from: 1635-6
O=C([C@H](NC([C@@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](N)CC1=CC=C(O)C=C1)=O)CC2=CNC3=C2C=CC=C3)=O)C4=CC(O)=CC(O)=C4)=O)C5=CC=C(O)C=C5)=O)C6=CC=C(O)C=C6)=O)CC7=CC=C(O)C=C7)=O)C8=CC=C(O)C=C8)O—
81635BKM31_54150, (BKM31_54160, BKM31_54165, BKM31_54195)TE
1635-7
from: 1635-7
O=C([C@@H]1NC([C@H](NC([C@H](NC([C@H](N)CC2=CC=C(O)C=C2)=O)CC3=CNC4=C3C=CC5=C4)=O)C6=CC(O)=CC(O)=C6)=O)N[C@H](C7=CC=C8C(Cl)=C7)C(N[C@@H](CC9=CC=C(OC%10=CC1=CC5=C%10O)C=C9)C(NC(C(O)=O)C%11=CC(O8)=C(O)C=C%11)=O)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture