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BGC0001627NRPS

Isonitrile lipopeptides

Producing organism
Mycobacterium tuberculosis H37Rv
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Mycobacteriales›Mycobacteriaceae›Mycobacterium›Mycobacterium tuberculosis complex
Biosynthetic class
NRPS (Type I)
Total steps
6
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map5 genes · 10,806 bp

TauDAACPAACPCAPCPTD2 kb10.8 kb visible · 10,806 bp total
Biosynthetic (core)
Biosynthetic (additional)
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TDTerminal reductase
TauDTauD oxygenase

Pathway Graphsteps arranged in biosynthetic order

6 steps · 5 edges
Step 1
Start
+Crotonic acid
Step 2
Rv0100;Rv0099
Step 3
Rv0098
Step 4
Rv0097
Step 5
Rv0101
+Lysine
Step 6MR
Rv0101
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions6 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11627-1Start—
Crotonic acid
O=C(O)/C=C/C—
21627-2Rv0100;Rv0099—
1627-1
from: 1627-1
O=C(O)/C=C/C—
31627-3Rv0098—
1627-2
from: 1627-2
O=C(O)C[C@H](NCC(O)=O)C—
41627-4Rv0097—
1627-3
from: 1627-3
O=C(O)C[C@H]([N+]#[C-])C—
51627-5Rv0101—
1627-4;1627-4;Lysine
from: 1627-4, 1627-4
O=C(NCCCC[C@H](NC(C[C@@H](C)[N+]#[C-])=O)C(O)=O)C[C@H]([N+]#[C-])C—
61627Rv0101MR
1627-5
from: 1627-5
O=C(NCCCC[C@H](NC(C[C@@H](C)[N+]#[C-])=O)CO)C[C@H]([N+]#[C-])C—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture