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BGC0001619PKS

Ibomycin

Producing organism
Streptomyces sp. WAC2288
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
28
DOI
MIBiG entry
View on MIBiG ↗
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ibomycin
C91H156N2O401918.20 Da

Gene Cluster Map41 genes · 146,358 bp

20 kb146.4 kb visible · 146,358 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
DHtDehydratase (DHt)
ACPSACP synthase
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

28 steps · 27 edges
Step 1Load
AKA59088.1
+Methylmalonyl-CoA
Step 23
Start
+N-acetyl glucosam…
Step 24
Start
+Glucose
Step 25
Start
+Rhamnose
Step 26
Start
+Rhodinose
Step 27
Start
+Vancosamine
Step 2M1
AKA59088.1
+Methylmalonyl-CoA
Step 3M2
AKA59088.1
+Methylmalonyl-CoA
Step 4M3
AKA59089.1
+Methylmalonyl-CoA
Step 5M4
AKA59089.1
+Methylmalonyl-CoA
Step 6M5
AKA59089.1
+Malonyl-CoA
Step 7M6
ibo19
+Malonyl-CoA
Step 8M7
ibo19
+Malonyl-CoA
Step 9M8
AKA59090.1
+Malonyl-CoA
Step 10M9
AKA59090.1
+Malonyl-CoA
Step 11M10
AKA59090.1
+Methylmalonyl-CoA
Step 12M11
AKA59091.1
+Malonyl-CoA
Step 13M12
AKA59091.1
+Malonyl-CoA
Step 14M13
AKA59091.1
+Malonyl-CoA
Inactive: DH
Step 15M14
AKA59091.1
+Methylmalonyl-CoA
Step 16M15
AKA59092.1
+Malonyl-CoA
Step 17M16
AKA59092.1
+Malonyl-CoA
Step 18M17
AKA59092.1
+Malonyl-CoA
Step 19M18
AKA59093.1
+Malonyl-CoA
Step 20M19
AKA59093.1
+Malonyl-CoA
Step 21
AKA59077.1
Step 22TE
AKA59093.1
Step 28
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions28 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11619-1AKA59088.1Loading
Methylmalonyl-CoA
O=C(O)CC—
21619-2AKA59088.1M1
1619-1;Methylmalonyl-CoA
from: 1619-1
O[C@H]([C@@H](C(O)=O)C)CC—
31619-3AKA59088.1M2
1619-2;Methylmalonyl-CoA
from: 1619-2
O[C@H]([C@@H]([C@H](O)[C@H](C(O)=O)C)C)CC—
41619-4AKA59089.1M3
1619-3;Methylmalonyl-CoA
from: 1619-3
O[C@H]([C@@H]([C@H](O)[C@H]([C@H](O)[C@@H](C(O)=O)C)C)C)CC—
51619-5AKA59089.1M4
1619-4;Methylmalonyl-CoA
from: 1619-4
O[C@H]([C@@H]([C@H](O)[C@H]([C@H](O)[C@@H]([C@@H](O)[C@H](C(O)=O)C)C)C)C)CC—
61619-6AKA59089.1M5
1619-5;Malonyl-CoA
from: 1619-5
O[C@H]([C@@H]([C@H](O)[C@H]([C@H](O)[C@@H]([C@@H](O)[C@H](/C=C/C(O)=O)C)C)C)C)CC—
71619-7ibo19M6
1619-6;Malonyl-CoA
from: 1619-6
O[C@H]([C@@H]([C@H](O)[C@H]([C@H](O)[C@@H]([C@@H](O)[C@H](/C=C/C=C/C(O)=O)C)C)C)C)CC—
81619-8ibo19M7
1619-7;Malonyl-CoA
from: 1619-7
O[C@H]([C@@H]([C@H](O)[C@H]([C@H](O)[C@@H]([C@@H](O)[C@H](/C=C/C=C/[C@@H](O)CC(O)=O)C)C)C)C)CC—
91619-9AKA59090.1M8
1619-8;Malonyl-CoA
from: 1619-8
O[C@H]([C@@H]([C@H](O)[C@H]([C@H](O)[C@@H]([C@@H](O)[C@H](/C=C/C=C/[C@@H](O)C[C@H](O)CC(O)=O)C)C)C)C)CC—
101619-10AKA59090.1M9
1619-9;Malonyl-CoA
from: 1619-9
O[C@H]([C@@H]([C@H](O)[C@H]([C@H](O)[C@@H]([C@@H](O)[C@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)CC(O)=O)C)C)C)C)CC—
111619-11AKA59090.1M10
1619-10;Methylmalonyl-CoA
from: 1619-10
O[C@H]([C@@H]([C@H](O)[C@H]([C@H](O)[C@@H]([C@@H](O)[C@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)[C@H](C(O)=O)C)C)C)C)C)CC—
121619-12AKA59091.1M11
1619-11;Malonyl-CoA
from: 1619-11
O[C@H]([C@@H]([C@H](O)[C@H]([C@H](O)[C@@H]([C@@H](O)[C@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)[C@H]([C@H](O)CC(O)=O)C)C)C)C)C)CC—
131619-13AKA59091.1M12
1619-12;Malonyl-CoA
from: 1619-12
O[C@H]([C@@H]([C@H](O)[C@H]([C@H](O)[C@@H]([C@@H](O)[C@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)[C@H]([C@H](O)CC(O)CC(O)=O)C)C)C)C)C)CC—
141619-14AKA59091.1M13
1619-13;Malonyl-CoA
from: 1619-13
O[C@H]([C@@H]([C@H](O)[C@H]([C@H](O)[C@@H]([C@@H](O)[C@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)[C@H]([C@H](O)CC(O)CC(CC(O)=O)=O)C)C)C)C)C)CC{'Inactive': ['DH']}
151619-15AKA59091.1M14
1619-14;Methylmalonyl-CoA
from: 1619-14
O[C@H]([C@@H]([C@H](O)[C@H]([C@H](O)[C@@H]([C@@H](O)[C@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)[C@H]([C@H](O)CC(O)CC(C[C@@H](O)[C@H](C(O)=O)C)=O)C)C)C)C)C)CC—
161619-16AKA59092.1M15
1619-15;Malonyl-CoA
from: 1619-15
O[C@H]([C@@H]([C@H](O)[C@H]([C@H](O)[C@@H]([C@@H](O)[C@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)[C@H]([C@H](O)CC(O)CC(C[C@@H](O)[C@H](CCC(O)=O)C)=O)C)C)C)C)C)CC—
171619-17AKA59092.1M16
1619-16;Malonyl-CoA
from: 1619-16
O[C@H]([C@@H]([C@H](O)[C@H]([C@H](O)[C@@H]([C@@H](O)[C@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)[C@H]([C@H](O)CC(O)CC(C[C@@H](O)[C@H](CC[C@H](O)CC(O)=O)C)=O)C)C)C)C)C)CC—
181619-18AKA59092.1M17
1619-17;Malonyl-CoA
from: 1619-17
O[C@H]([C@@H]([C@H](O)[C@H]([C@H](O)[C@@H]([C@@H](O)[C@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)[C@H]([C@H](O)CC(O)CC(C[C@@H](O)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)C)=O)C)C)C)C)C)CC—
191619-19AKA59093.1M18
1619-18;Malonyl-CoA
from: 1619-18
O[C@H]([C@@H]([C@H](O)[C@H]([C@H](O)[C@@H]([C@@H](O)[C@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)[C@H]([C@H](O)CC(O)CC(C[C@@H](O)[C@H](CC[C@@H](O)C[C@@H](O)C/C=C/C(O)=O)C)=O)C)C)C)C)C)CC—
201619-20AKA59093.1M19
1619-19;Malonyl-CoA
from: 1619-19
O[C@H]([C@@H]([C@H](O)[C@H]([C@H](O)[C@@H]([C@@H](O)[C@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)[C@H]([C@H](O)CC(O)CC(C[C@@H](O)[C@H](CC[C@@H](O)C[C@@H](O)C/C=C/C=C/C(O)=O)C)=O)C)C)C)C)C)CC—
211619-21AKA59077.1—
1619-20
from: 1619-20
O[C@H]([C@@H]([C@H](O)[C@H]([C@H](O)[C@@H]([C@@H](O)[C@H](/C=C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)[C@H]([C@H](O)CC(O)C(O)C(C[C@@H](O)[C@H](CC[C@@H](O)C[C@@H](O)C/C=C/C=C/C(O)=O)C)=O)C)C)C)C)C)CC—
221619-22AKA59093.1TE
1619-21
from: 1619-21
CC[C@H](O)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)C1[C@@H](C)/C=C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)C[C@@H](O)[C@H](C)C2OC(C[C@H](O)[C@@H](CC[C@@H](C[C@@H](C/C=C/C=C/C(O1)=O)O)O)C)(O)C(O)C(O)C2—
231619-23Start—
N-acetyl glucosamine
OC[C@H]1O[C@H](O)[C@H](NC(C)=O)[C@@H](O)[C@@H]1O—
241619-24Start—
Glucose
OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O—
251619-25Start—
Rhamnose
C[C@H]1O[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]1O—
261619-26Start—
Rhodinose
O[C@H]1CC[C@@H](O)[C@@H](C)O1—
271619-27Start—
Vancosamine
O[C@H]1C[C@@](N)(C)[C@H](O)[C@H](C)O1—
281619?—
1619-22;1619-23;1619-24;1619-25;1619-25;1619-26;1619-26;1619-27
from: 1619-22, 1619-23, 1619-24, 1619-25, 1619-25, 1619-26, 1619-26, 1619-27
CC[C@H](O[C@H]1CC[C@@H](O[C@H]2CC[C@@H](O[C@H]3C[C@@](N)(C)[C@H](O)[C@H](C)O3)[C@@H](C)O2)[C@@H](C)O1)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)C4[C@@H](C)/C=C/C=C/[C@@H](O)C[C@H](O)C[C@@H](O)CC(O[C@@H]5[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O5)[C@H](C)C6OC(C[C@H](O[C@H]7[C@@H](O[C@H]8[C@@H](O)[C@@H](O)[C@H](O)[C@@H](C)O8)[C@@H](O[C@H]9[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O9)[C@H](O)[C@@H](C)O7)[C@@H](CC[C@@H](C[C@@H](C/C=C/C=C/C(O4)=O)O)O)C)(O)C(O)C(O)C6—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture