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BGC0001611PKS

Guangnanmycin

Producing organism
Streptomyces sp. CB01883
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Type I)
Total steps
12
DOI
MIBiG entry
View on MIBiG ↗
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guangnanmycin

Gene Cluster Map28 genes · 72,893 bp

AKSKSKSAKSKSKSKS10 kb72.9 kb visible · 72,893 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
CyHeterocyclization (Cy)
TdTrans-AT docking
DH2Dehydratase (DH2)
DHtDehydratase (DHt)
ECHEnoyl-CoA hydratase
MTMethyltransferase
BELBeta-elim. lyase
LPGLPG synthase C
ACPβACP (β-branching)
ACPSACP synthase
AmTAminotransferase I/II

Pathway Graphsteps arranged in biosynthetic order

12 steps · 11 edges
Step 1Load
gnmB
Step 2M1
gnmH
Trans-AT
Step 3M2
gnmH;gnmT
Trans-AT
Step 4M3
gnmT
Trans-AT
Step 5M4
gnmT
Trans-AT
Step 6M5
gnmT
Trans-AT
Step 7M6
gnmT
Trans-AT
Step 8
gnmT
Step 9
gnmT
Step 10
gnmT
Step 11TE
gnmT
Step 12
gnmP
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions12 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11611-1gnmBLoading
NC1(CC1)C2=NC(C(O)=O)=CS2—
21611-2gnmHM1
1611-1
from: 1611-1
C/C(C(O)=O)=C/C1=CSC(C2(N)CC2)=N1{'transAT': ['gnmG/gnmK', 'M…
31611-3gnmH;gnmTM2
1611-2
from: 1611-2
CC(/C=C/C(O)=O)=C/C1=CSC(C2(N)CC2)=N1{'transAT': ['gnmG/gnmK', 'M…
41611-4gnmTM3
1611-3
from: 1611-3
CC(/C=C/C(CC(O)=O)=C)=C/C1=CSC(C2(N)CC2)=N1{'transAT': ['gnmG/gnmK', 'M…
51611-5gnmTM4
1611-4
from: 1611-4
CC(/C=C/C(C/C=C(C)/C(O)=O)=C)=C/C1=CSC(C2(N)CC2)=N1{'transAT': ['gnmG/gnmK', 'M…
61611-6gnmTM5
1611-5
from: 1611-5
CC(/C=C/C(C/C=C(C)/CCC(O)=O)=C)=C/C1=CSC(C2(N)CC2)=N1{'transAT': ['gnmG/gnmK', 'M…
71611-7gnmTM6
1611-6
from: 1611-6
CC(/C=C/C(C/C=C(C)/CCC(CC(O)=O)=O)=C)=C/C1=CSC(C2(N)CC2)=N1{'transAT': ['gnmG/gnmK', 'M…
81611-8gnmT—
1611-7
from: 1611-7
CC(/C=C/C(C/C=C(C)/CCC(CC(O)=O)CC(O)=O)=C)=C/C1=CSC(C2(N)CC2)=N1—
91611-9gnmT—
1611-8
from: 1611-8
CC(/C=C/C(C/C=C(C)/CCC(CC(O)=O)(SSC[C@@H](C(O)=O)N)CC(O)=O)=C)=C/C1=CSC(C2(N)CC2)=N1—
101611-10gnmT—
1611-9
from: 1611-9
CC(/C=C/C(C/C=C(C)/CCC(CC(O)=O)(SS)CC(O)=O)=C)=C/C1=CSC(C2(N)CC2)=N1—
111611-11gnmTTE
1611-10
from: 1611-10
CC(/C=C/C(C/C=C(C)/CC[C@@](SS)(CC(O)=O)CC(NC12CC2)=O)=C)=C/C3=CSC1=N3—
121611gnmP—
1611-11
from: 1611-11
CC(/C=C/C(C/C=C(C)/CC[C@@](SSC)(CC(O)=O)CC(NC12CC2)=O)=C)=C/C3=CSC1=N3—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture