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BGC0001597PKS

Fluvirucin B2

Producing organism
Actinomadura fulva subsp. indica
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Streptosporangiales›Thermomonosporaceae›Actinomadura
Biosynthetic class
PKS (Unknown)
Total steps
13
DOI
MIBiG entry
View on MIBiG ↗
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fluvirucin B2
C25H48N2O5456.36 Da

Gene Cluster Map36 genes · 71,515 bp

AERKSKSKSKSKSA10 kb71.5 kb visible · 71,515 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
ACPSACP synthase
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

13 steps · 12 edges
Step 1
Start
+L-Asparate
Step 12
Start
+L-Mycosamine
Step 2
flvN;flvL
Step 3
flvO
Step 4
flvM
Step 5Load
flvK;flvP1
Step 6M1
flvP1
+Ethylmalonyl-CoA
Step 7M2
flvP1
+Malonyl-CoA
Step 8M3
flvP2
+Ethylmalonyl-CoA
Step 9M4
flvP2
+Malonyl-CoA
Step 10M5
flvP3
+Ethylmalonyl-CoA
Step 11TE
flvP3, flvJ
Step 13
flvS5
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions13 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11597-1Start—
L-Asparate
O=C([C@H](CC(O)=O)N)O—
21597-2flvN;flvL—
1597-1
from: 1597-1
O=C([C@H](CC(O)=O)N)O—
31597-3flvO—
1597-2
from: 1597-2
NCCC(O)=O—
41597-4flvM—
1597-3
from: 1597-3
O=C(O)CCN[R]—
51597-5flvK;flvP1Loading
1597-4
from: 1597-4
O=C(O)CCN[R]—
61597-6flvP1M1
1597-5;Ethylmalonyl-CoA
from: 1597-5
[R]NCCC[C@H](C(O)=O)CC—
71597-7flvP1M2
1597-6;Malonyl-CoA
from: 1597-6
[R]NCCC[C@H]([C@H](O)CC(O)=O)CC—
81597-8flvP2M3
1597-7;Ethylmalonyl-CoA
from: 1597-7
[R]NCCC[C@H]([C@H](O)CC[C@H](C(O)=O)CC)CC—
91597-9flvP2M4
1597-8;Malonyl-CoA
from: 1597-8
[R]NCCC[C@H]([C@H](O)CC[C@H](CCC(O)=O)CC)CC—
101597-10flvP3M5
1597-9;Ethylmalonyl-CoA
from: 1597-9
[R]NCCC[C@H]([C@H](O)CC[C@H](CCC[C@H](C(O)=O)CC)CC)CC—
111597-11flvP3, flvJTE
1597-10
from: 1597-10
CC[C@@H]1CCC[C@H](CC)CC[C@@H](O)[C@H](CC)CCCNC1=O—
121597-12Start—
L-Mycosamine
C[C@H]1[C@H](O)[C@@H](N)[C@@H](O)[C@H]([R])O1—
131597flvS5—
1597-11;1597-12
from: 1597-11, 1597-12
CC[C@@H]1CCC[C@H](CC)CC[C@@H](O[C@H]2[C@H](O)[C@H](N)[C@@H](O)[C@H](C)O2)[C@H](CC)CCCNC1=O—
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