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BGC0001593NRPS

Ficellomycin

Producing organism
Streptomyces ficellus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
18
DOI
MIBiG entry
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Ficellomycin
C13H24N6O3312.19 Da

Gene Cluster Map26 genes · 29,585 bp

AmTAmTCATE5 kb29.6 kb visible · 29,585 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)
AmTAminotransferase III
AmTAminotransferase V

Pathway Graphsteps arranged in biosynthetic order

18 steps · 17 edges
Step 1
ARF06222.1
Step 16M1
?
+Valine
Step 2
ARF06220.1
Step 3
ARF06211.1
Step 4
ARF06212.1
Step 5
ARF06214.1, ARF06215.1
Step 6
?
Step 7
ARF06207.1
Step 8
ARF06223.1
Step 9
?
Step 10
ARF06224.1
Step 11
ARF06216.1
Step 12
ARF06227.1
Step 13
ARF06208.1, ARF06209.1,…
Step 14
?
Step 15
ARF06221.1
Step 17M2
ARF06222.1
Step 18TE
ARF06222.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions18 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11593-1ARF06222.1—
NC(C(O)=O)CCC(O)=O—
21593-2ARF06220.1—
1593-1
from: 1593-1
O=C(O)CCC(C(O)=O)NC(C)=O—
31593-3ARF06211.1—
1593-2
from: 1593-2
O=C(OP([O-])([O-])=O)CCC(C(O)=O)NC(C)=O—
41593-4ARF06212.1—
1593-3
from: 1593-3
O=C([H])CCC(C(O)=O)NC(C)=O—
51593-5ARF06214.1, ARF06215.1—
1593-4
from: 1593-4
OC(C([R])(O)CO)CCC(C(O)=O)NC(C)=O—
61593-6?—
1593-5
from: 1593-5
OC(C(CO)=O)CCC(C(O)=O)NC(C)=O—
71593-7ARF06207.1—
1593-6
from: 1593-6
OC(C(N)CO)CCC(C(O)=O)NC(C)=O—
81593-8ARF06223.1—
1593-7
from: 1593-7
OC(C(N)CO)C/C=C(C(O)=O)/NC(C)=O—
91593-9?—
1593-8
from: 1593-8
O=C(O)C(C1CC(O)C(CO)N1)NC(C)=O—
101593-10ARF06224.1—
1593-9
from: 1593-9
O=C(O)C(C1CC(C(CO)N1)=O)NC(C)=O—
111593-11ARF06216.1—
1593-10
from: 1593-10
O=C(O)C(C1CC(N)C(CO)N1)NC(C)=O—
121593-12ARF06227.1—
1593-11
from: 1593-11
O=C(O)C(C1CC(NC(N)=N)C(CO)N1)NC(C)=O—
131593-13ARF06208.1, ARF06209.1, ARF06210.1, ARF06219.1—
1593-12
from: 1593-12
O=C(O)C(C1CC(NC(N)=N)C(COS([O-])([O-])[O-])N1)NC(C)=O—
141593-14?—
1593-13
from: 1593-13
O=C(O)C(C1CC(NC(N)=N)C2N1C2)NC(C)=O—
151593-15ARF06221.1—
1593-14
from: 1593-14
NC(C1CC(NC(N)=N)C2N1C2)C(O)=O—
161593-16?M1
Valine
NC(C(O)=O)C(C)C—
171593-17ARF06222.1M2
1593-15;1593-16
from: 1593-15, 1593-16
O=C(O)C(C1CC(NC(N)=N)C2N1C2)NC(C(C(C)C)N)=O—
181593ARF06222.1TE
1593-17
from: 1593-17
O=C(O)C(C1CC(NC(N)=N)C2N1C2)NC(C(C(C)C)N)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture