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BGC0001582NRPS

Ecumicin

Producing organism
Nonomuraea sp. MJM5123
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Streptosporangiales›Streptosporangiaceae›Nonomuraea
Biosynthetic class
NRPS (Type I)
Total steps
16
DOI
MIBiG entry
—
Loading…
ecumicin
C83H134N14O171599.01 Da

Pathway Graphsteps arranged in biosynthetic order

16 steps · 15 edges
Step 1M1
AIW58892.1
+Valine
Step 2M2
AIW58892.1
+Valine
Step 3M3
AIW58892.1
+Isoleucine
Step 4M4
AIW58892.1
+Threonine
Step 5M5
AIW58892.1
+Threonine
Step 6M6
AIW58892.1
+Valine
Step 7M7
AIW58892.1
+Leucine
Step 8M8
AIW58892.1
+Valine
Step 9M9
AIW58892.1
+Valine
Step 10M10
AIW58892.1
Step 11M11
AIW58892.1
+Valine
Step 12M12
AIW58892.1
+Phenylalanine
Step 13M13
AIW58892.1
+Valine
Step 14TE
AIW58892.1
Step 15
AIW58897.1, AIW58898.1
Step 16
AIW58896.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions16 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11582-1AIW58892.1M1
Valine
OC([C@@H](N(C)C)C(C)C)=O—
21582-2AIW58892.1M2
1582-1;Valine
from: 1582-1
OC([C@H](C(C)C)NC([C@@H](N(C)C)C(C)C)=O)=O—
31582-3AIW58892.1M3
1582-2;Isoleucine
from: 1582-2
OC([C@@H](N(C([C@H](C(C)C)NC([C@@H](N(C)C)C(C)C)=O)=O)C)[C@H](C)CC)=O—
41582-4AIW58892.1M4
1582-3;Threonine
from: 1582-3
OC([C@@H](NC([C@@H](N(C([C@H](C(C)C)NC([C@@H](N(C)C)C(C)C)=O)=O)C)[C@H](C)CC)=O)[C@@H](C)O)=O—
51582-5AIW58892.1M5
1582-4;Threonine
from: 1582-4
OC([C@@H](N(C([C@@H](NC([C@@H](N(C([C@H](C(C)C)NC([C@@H](N(C)C)C(C)C)=O)=O)C)[C@H](C)CC)=O)[C@@H](C)O)=O)C)[C@H](O)C)=O—
61582-6AIW58892.1M6
1582-5;Valine
from: 1582-5
OC([C@@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C([C@H](C(C)C)NC([C@@H](N(C)C)C(C)C)=O)=O)C)[C@H](C)CC)=O)[C@@H](C)O)=O)C)[C@H](O)C)=O)C(C)C)=O—
71582-7AIW58892.1M7
1582-6;Leucine
from: 1582-6
OC([C@@H](N(C([C@@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C([C@H](C(C)C)NC([C@@H](N(C)C)C(C)C)=O)=O)C)[C@H](C)CC)=O)[C@@H](C)O)=O)C)[C@H](O)C)=O)C(C)C)=O)C)CC(C)C)=O—
81582-8AIW58892.1M8
1582-7;Valine
from: 1582-7
OC([C@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C([C@H](C(C)C)NC([C@@H](N(C)C)C(C)C)=O)=O)C)[C@H](C)CC)=O)[C@@H](C)O)=O)C)[C@H](O)C)=O)C(C)C)=O)C)CC(C)C)=O)C(C)C)=O—
91582-9AIW58892.1M9
1582-8;Valine
from: 1582-8
OC([C@H](C(C)C)N(C([C@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C([C@H](C(C)C)NC([C@@H](N(C)C)C(C)C)=O)=O)C)[C@H](C)CC)=O)[C@@H](C)O)=O)C)[C@H](O)C)=O)C(C)C)=O)C)CC(C)C)=O)C(C)C)=O)C)=O—
101582-10AIW58892.1M10
1582-9:Tryptophan
from: 1582-9:Tryptophan
OC([C@@H](CC1=CNC2=C1C=CC=C2)N(C)C([C@H](C(C)C)N(C([C@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C([C@H](C(C)C)NC([C@@H](N(C)C)C(C)C)=O)=O)C)[C@H](C)CC)=O)[C@@H](C)O)=O)C)[C@H](O)C)=O)C(C)C)=O)C)CC(C)C)=O)C(C)C)=O)C)=O)=O—
111582-11AIW58892.1M11
1582-10;Valine
from: 1582-10
OC([C@@H](C(C)C)NC([C@@H](CC1=CNC2=C1C=CC=C2)N(C)C([C@H](C(C)C)N(C([C@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C([C@H](C(C)C)NC([C@@H](N(C)C)C(C)C)=O)=O)C)[C@H](C)CC)=O)[C@@H](C)O)=O)C)[C@H](O)C)=O)C(C)C)=O)C)CC(C)C)=O)C(C)C)=O)C)=O)=O)=O—
121582-12AIW58892.1M12
1582-11;Phenylalanine
from: 1582-11
OC([C@@H](CC1=CC=CC=C1)NC([C@@H](C(C)C)NC([C@@H](CC2=CNC3=C2C=CC=C3)N(C)C([C@H](C(C)C)N(C([C@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C([C@H](C(C)C)NC([C@@H](N(C)C)C(C)C)=O)=O)C)[C@H](C)CC)=O)[C@@H](C)O)=O)C)[C@H](O)C)=O)C(C)C)=O)C)CC(C)C)=O)C(C)C)=O)C)=O)=O)=O)=O—
131582-13AIW58892.1M13
1582-12;Valine
from: 1582-12
CC(C)[C@H](NC([C@@H](CC1=CC=CC=C1)NC([C@@H](C(C)C)NC([C@@H](CC2=CNC3=C2C=CC=C3)N(C)C([C@H](C(C)C)N(C([C@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C([C@H](C(C)C)NC([C@@H](N(C)C)C(C)C)=O)=O)C)[C@H](C)CC)=O)[C@@H](C)O)=O)C)[C@H](O)C)=O)C(C)C)=O)C)CC(C)C)=O)C(C)C)=O)C)=O)=O)=O)=O)C(O)=O—
141582-14AIW58892.1TE
1582-13
from: 1582-13
CN(C([C@@H](NC([C@@H](N(C([C@@H](NC([C@H]([C@H](O)C)N(C)C([C@@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C)C)C(C)C)=O)C(C)C)=O)C)[C@H](C)CC)=O)[C@@H](C)OC1=O)=O)=O)C(C)C)=O)C)CC(C)C)=O)C(C)C)=O)[C@@H](C(C)C)C(N(C)C(C(NC(C(N[C@@H](C(N[C@H]1C(C)C)=O)CC2=CC=CC=C2)=O)C(C)C)=O)CC3=CNC4=C3C=CC=C4)=O—
151582-15AIW58897.1, AIW58898.1—
1582-14
from: 1582-14
CN(C([C@@H](NC([C@@H](N(C([C@@H](NC([C@H]([C@H](O)C)N(C)C([C@@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C)C)C(C)C)=O)C(C)C)=O)C)[C@H](C)CC)=O)[C@@H](C)OC1=O)=O)=O)C(C)C)=O)C)CC(C)C)=O)C(C)C)=O)[C@@H](C(C)C)C(N(C)C(C(NC(C(N[C@@H](C(N[C@H]1C(C)C)=O)CC2=CC=CC=C2)=O)C(C)C)=O)CC3=CNC4=C3C(OC)=CC=C4)=O—
161582AIW58896.1—
1582-15
from: 1582-15
CN(C([C@@H](NC([C@@H](N(C([C@@H](NC([C@H]([C@H](O)C)N(C)C([C@@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C)C)C(C)C)=O)C(C)C)=O)C)[C@H](C)CC)=O)[C@@H](C)OC1=O)=O)=O)C(C)C)=O)C)CC(C)C)=O)C(C)C)=O)[C@@H](C(C)C)C(N(C)C(C(NC(C(N[C@@H](C(N[C@H]1C(C)C)=O)C(O)C2=CC=CC=C2)=O)C(C)C)=O)CC3=CNC4=C3C(OC)=CC=C4)=O—
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