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BGC0001567NRPS

Cysteoamide

Producing organism
Streptomyces lincolnensis
Taxonomy
BacteriaActinomycetotaActinomycetesKitasatosporalesStreptomycetaceaeStreptomyces
Biosynthetic class
NRPS (Type I)
Total steps
10
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map11 genes · 30,866 bp

CATECACAETgrCACAETgr5 kb30.9 kb visible · 30,866 bp total
Biosynthetic (core)
Biosynthetic (additional)
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
CnCOM N-term
CcCOM C-term
TEThioesterase (TE)
EEpimerization (E)
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

10 steps · 9 edges
Step 1
Start
Step 4
Start
Step 7M3
SLINC_0743
+L-Threonine
Step 8M4
SLINC_0743
+D-Leucine
Step 9M5
SLINC_0742
+β-alanine
Step 10TE
SLINC_0742, ?
Step 2
SLINC_0746, SLINC_0747
Step 5
SLINC_0745
Step 3M1
SLINC_0744
+L-Valine
Step 6M2
SLINC_0744
Starting stepIntermediateFinal productModuleLoadingTENo modulePKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions10 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11567-1Start
O=C(C(O)=O)CC1=CC=CC=C1
21567-2SLINC_0746, SLINC_0747
1567-1
from: 1567-1
O=C([R])CC1=CC=CC=C1
31567-3SLINC_0744M1
1567-2;L-Valine
from: 1567-2
O=C(N[C@H](C(O)=O)C(C)C)CC1=CC=CC=C1
41567-4Start
O=C(O)[C@@H](N)COP([O-])([O-])=O
51567-5SLINC_0745
1567-4
from: 1567-4
O=C(O)[C@@H](N)CS(=O)(O)=O
61567-6SLINC_0744M2
1567-5;1567-7
from: 1567-5, 1567-7
O=C(N[C@H](C(N[C@@H](C(O)=O)CS(=O)(O)=O)=O)C(C)C)CC1=CC=CC=C1
71567-7SLINC_0743M3
1567-6;L-Threonine
from: 1567-6
O=C(N[C@H](C(N[C@@H](C(N[C@H](C(O)=O)[C@H](O)C)=O)CS(=O)(O)=O)=O)C(C)C)CC1=CC=CC=C1
81567-8SLINC_0743M4
1567-7;D-Leucine
from: 1567-7
O=C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@@H](C(O)=O)CC(C)C)=O)[C@H](O)C)=O)CS(=O)(O)=O)=O)C(C)C)CC1=CC=CC=C1
91567-9SLINC_0742M5
1567-8;β-alanine
from: 1567-8
O=C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@@H](C(NCCC(O)=O)=O)CC(C)C)=O)[C@H](O)C)=O)CS(=O)(O)=O)=O)C(C)C)CC1=CC=CC=C1
101567SLINC_0742, ?TE
1567-9
from: 1567-9
O=C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@@H](C(NCC1)=O)[C@H](O)C(C)C)=O)[C@H](OC1=O)C)=O)CS(=O)(O)=O)=O)C(C)C)CC2=CC=CC=C2
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