NPdia

BGC0001562NRPS

Curacomycin

Producing organism: Streptomyces curacoi
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: NRPS (Type I)
Total steps: 8
DOI: 10.1002/ajoc.201700433
MIBiG entry: View on MIBiG ↗

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curacomycin

C₃₇H₅₆ClN₉O₈789.39 Da

Biosynthetic (core)

Biosynthetic (additional)

Unknown

Domains

Condensation (C)

Adenylation (A)

Peptidyl carrier (PCP)

Epimerization (E)

Aminotransferase IV

TauD oxygenase

TIGR01720

8 steps · 7 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions8 steps

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`1562-1`	Start	—	Tryptophan	`N[C@H](C(O)=O)CC1=CNC2=C1C=CC=C2`	—
2	`1562-2`	AQI70_05495	M1	1562-1 from: 1562-1	`N[C@H](C(O)=O)CC1=CNC2=C1C=C(Cl)C=C2`	—
3	`1562-3`	AQI70_05495	M2	1562-2;Valine from: 1562-2	`N[C@H](C(N[C@@H](C(O)=O)C(C)C)=O)CC1=CNC2=C1C=C(Cl)C=C2`	—
4	`1562-4`	AQI70_05495	M3	1562-3;Leucine from: 1562-3	`N[C@H](C(N[C@@H](C(C[C@@H](C(O)=O)CC(C)C)=O)C(C)C)=O)CC1=CNC2=C1C=C(Cl)C=C2`	—
5	`1562-5`	AQI70_05495	M4	1562-4;Isoleucine from: 1562-4	`N[C@H](C(N[C@@H](C(C[C@@H](C(N[C@H](C(O)=O)[C@@H](C)CC)=O)CC(C)C)=O)C(C)C)=O)CC1=CNC2=C1C=C(Cl)C=C2`	—
6	`1562-6`	AQI70_05500	M5	1562-5;Ornithine from: 1562-5	`N[C@H](C(N[C@@H](C(C[C@@H](C(N[C@H](C(C[C@H](C(O)=O)CCCN)=O)[C@@H](C)CC)=O)CC(C)C)=O)C(C)C)=O)CC1=CNC2=C1C=C(Cl)C=C2`	—
7	`1562-7`	AQI70_05500	M6	1562-6;Asparagine from: 1562-6	`N[C@H](C(N[C@@H](C(C[C@@H](C(N[C@H](C(C[C@H](C(NC(C(O)=O)C(C(N)=O)O)=O)CCCN)=O)[C@@H](C)CC)=O)CC(C)C)=O)C(C)C)=O)CC1=CNC2=C1C=C(Cl)C=C2`	—
8	`1562`	?	—	1562-7 from: 1562-7	`O=C(C(C(C(N)=O)O)NC([C@H](CCCN)NC([C@H](C(CC)C)NC1=O)=O)=O)N[C@@H](CC2=CNC3=C2C=C(Cl)C=C3)C(N[C@H](C(C)C)C(N[C@@H]1CC(C)C)=O)=O`	—

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