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BGC0001556Hybrid

Combamide

Producing organism
Streptomyces sp
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
14
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map9 genes · 21,510 bp

KSATDHKRCATE5 kb21.5 kb visible · 21,510 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)

Pathway Graphsteps arranged in biosynthetic order

14 steps · 13 edges
Step 1
cbmA
Iterative
Step 2
cbmA
Iterative
Step 3
cbmA
+Ornithine
Step 4
cbmC
Step 6
cbmC
Step 5
cbmB
Step 7
cbmB
Step 9
cbmB
Step 8
cbmD, Spontaneous
Step 10
cbmD
Step 12
cbmD
Step 11
cbmD, AWO77092.1
Step 13
cbmD
+1556(4)
Step 14
AWO77092.1
+1556(4)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions14 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11556-1cbmA—
C/C=C/C=C/C=C/C=C/C=C/C(O)=O{'Iteration': [(['None'], 'M…
21556-2cbmA—
C/C=C/C=C/C=C/C=C/C(CC(O)=O)=O{'Iteration': [(['None'], 'M…
31556-3cbmA—
1556-1;1556-2;Ornithine
from: 1556-1, 1556-2
O=C(NCCC[C@@]1([H])C(/C(C(N1)=O)=C(O)\C=C\C=C\C=C\C=C\C)=O)/C=C/C=C/C=C/C=C/C=C/C—
41556-4cbmC—
1556-3
from: 1556-3
C[C@@H]1[C@@H](CC)C[C@](/C=C/C=C/C=C/C(NCCC[C@]2([H])NC3=O)=O)([H])[C@@]1([H])/C=C/C=C/C=C/C(O)=C3\C2=O—
51556(1)cbmB—
1556-4
from: 1556-4
C[C@@H]1[C@@H](CC)C[C@](C2)([H])[C@@]1([H])[C@]3([H])[C@]2([H])/C=C/C=C/C(NCCC[C@@]4([H])C(/C(C(N4)=O)=C(O)\C=C\C=C\C3)=O)=O—
61556-6cbmC—
1556-3
from: 1556-3
C[C@@H]1[C@H](CC)C[C@](/C=C/C=C/C=C/C(NCCC[C@]2([H])NC3=O)=O)([H])[C@@]1([H])/C=C/C=C/C=C/C(O)=C3\C2=O—
71556-7cbmB—
1556-6
from: 1556-6
C[C@@H]1[C@H](CC)C[C@](C2)([H])[C@@]1([H])[C@]3([H])[C@@]2([H])/C=C/C=C/C(NCCCC4C(/C(C(N4)=O)=C(O)\C=C\C=C\C3)=O)=O—
81556(2)cbmD, Spontaneous—
1556-7
from: 1556-7
CC([C@@H]1C[C@]2([H])[C@]([C@](C[C@]3([H])[C@@]4([H])/C=C\[C@@](C(NCCCC5NC6=O)=O)([H])[C@@](/C(O)=C6\C5=O)([H])/C=C\3)([H])[C@]4([H])C2)([H])[C@@H]1C)=O—
91556-9cbmB—
1556-6
from: 1556-6
C[C@@H]1[C@H](CC)C[C@](C2)([H])[C@@]1([H])[C@]3([H])[C@]2([H])/C=C/C=C/C(NCCCC4C(/C(C(N4)=O)=C(O)\C=C\C=C\C3)=O)=O—
101556-10cbmD—
1556-9
from: 1556-9
C[C@@H]1[C@H]([C@H](O)C)C[C@](C2)([H])[C@@]1([H])[C@]3([H])[C@]2([H])/C=C/C=C/C(NCCCC4C(/C(C(N4)=O)=C(O)\C=C\C=C\C3)=O)=O—
111556(3)cbmD, AWO77092.1—
1556-10
from: 1556-10
C[C@@H]1[C@H](C(C)=O)C[C@]2([H])[C@@]1([H])[C@@]([H])(CC[C@H]3[C@H]4C/C=C\C(NCCC[C@@]5([H])C(/C(C(N5)=O)=C(O)\C=C\3)=O)=O)[C@@]4([H])C2—
121556(4)cbmD—
1556-9
from: 1556-9
C[C@@H]1[C@@]([C@H](O)C)(O)C[C@](C2)([H])[C@@]1([H])[C@]3([H])[C@]2([H])/C=C/C=C/C(NCCCC4C(/C(C(N4)=O)=C(O)\C=C\C=C\C3)=O)=O—
131556(5)cbmD—
1556(4)
C[C@@H]1[C@@](C(C)=O)(O)C[C@](C2)([H])[C@@]1([H])[C@]3([H])[C@]2([H])/C=C/C=C/C(NCCCC4C(/C(C(N4)=O)=C(O)\C=C\C=C\C3)=O)=O—
141556(6)AWO77092.1—
1556(4)
C[C@@H]1[C@@](C(C)=O)(O)C[C@]2([H])[C@@]1([H])[C@@]([H])(CC[C@H]3[C@H]4C/C=C\C(NCCC[C@@]5([H])C(/C(C(N5)=O)=C(O)\C=C\3)=O)=O)[C@@]4([H])C2—
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