NPdia

BGC0001553Hybrid

Clifednamide A

Producing organism: Streptomyces sp. JV178
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: NRPS (Type I);PKS (Unknown)
Total steps: 9
DOI: 10.1002/anie.201402078 10.1021/acssynbio.7b00349
MIBiG entry: View on MIBiG ↗

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clifednamide A

C₂₉H₃₆N₂O₅492.26 Da

Biosynthetic (core)

Biosynthetic (additional)

Transport

Unknown

Domains

Ketosynthase (KS)

Acyltransferase (AT)

Dehydratase (DH)

Enoylreductase (ER)

Ketoreductase (KR)

Acyl carrier (ACP)

Condensation (C)

Adenylation (A)

Peptidyl carrier (PCP)

Thioesterase (TE)

9 steps · 8 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions9 steps

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`1553-1`	AUD08663.1	—		`C/C=C/C=C/C=C/C=C/C(CC(O)=O)=O`	{'Iteration': [(['None'], 'M…
2	`1553-2`	AUD08663.1	—	1553-1;Ornithine from: 1553-1	`C/C=C/C=C/C=C/C=C/C(CC(N[C@@H](CCCN)C(O)=O)=O)=O`	—
3	`1553-3`	AUD08663.1	—		`C/C=C/C=C/C=C/C=C/C=C/C(O)=O`	{'Iteration': [(['None'], 'M…
4	`1553-4`	AUD08663.1	—	1553-2;1553-3 from: 1553-2, 1553-3	`C/C=C/C=C/C=C/C=C/C(CC(N[C@@H](CCCNC(/C=C/C=C/C=C/C=C/C=C/C)=O)C(O)=O)=O)=O`	—
5	`1553-5`	AUD08663.1	TE	1553-4 from: 1553-4	`O=C(/C=C/C=C/C=C/C=C/C=C/C)NCCC[C@H]1NC(C(C(/C=C/C=C/C=C/C=C/C)=O)=C1O)=O`	—
6	`1553-6`	AUD08665.1	—	1553-5 from: 1553-5	`CC[C@H]([C@H](C)CC([H])C([H])/C=C/C=C/C(C1=C2O)=O)C([H])CCC([H])/C=C/C=C/C(NCCC[C@H]2NC1=O)=O`	—
7	`1553-7`	(AUD08665.1/Spontaneous)?	—	1553-6 from: 1553-6	`CC[C@H]1[C@]2([H])C=C[C@@](/C=C/C=C/C(NCCC[C@H]3NC4=O)=O)([H])[C@@](/C=C/C=C/C(C4=C3O)=O)([H])[C@@]2([H])C[C@H]1C`	—
8	`1553-8`	AUD08666.1	—	1553-7 from: 1553-7	`CC[C@H]1[C@]2([H])C=C[C@@]([C@H]3C/C=C\C(NCCC[C@H]4NC5=O)=O)([H])[C@@](C=C3/C=C/C(C5=C4O)=O)([H])[C@@]2([H])C[C@H]1C`	—
9	`1553`	AUD08664.1	—	1553-8 from: 1553-8	`CC([C@H]1[C@]2([H])C=C[C@@]([C@H]3C/C=C\C(NCCC[C@H]4NC5=O)=O)([H])[C@@](C=C3/C=C/C(C5=C4O)=O)([H])[C@@]2([H])C[C@H]1C)=O`	—

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