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BGC0001537PKS

Butyrolactol A

Producing organism
Streptomyces sp. NBRC 110030
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
13
DOI
MIBiG entry
View on MIBiG ↗
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butyrolactol A
C28H46O9526.31 Da

Gene Cluster Map15 genes · 68,929 bp

KSKSKSKSKSKSKSKSKSKSKS10 kb68.9 kb visible · 68,929 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
FkFkbH-like
DHtDehydratase (DHt)

Pathway Graphsteps arranged in biosynthetic order

13 steps · 12 edges
Step 1Load
APK71_RS29920
+Alkylmalonyl-CoA
Step 2M1
APK71_RS29920
+Malonyl-CoA
Step 3M2
APK71_RS29920
+Malonyl-CoA
{'Missing': ['DH']}
Step 4M3
APK71_RS29920
+Malonyl-CoA
Step 5M4
APK71_RS29935
+Malonyl-CoA
Step 6M5
APK71_RS29940
+Malonyl-CoA
Step 7M6
APK71_RS29940
+Malonyl-CoA
Step 8M7
APK71_RS29945
+Methylmalonyl-CoA
Step 9M8
APK71_RS29945
+Hydroxymalonyl-CoA
{'Missing': ['AT']}
Step 10M9
APK71_RS29950
+Hydroxymalonyl-CoA
Step 11M10
APK71_RS29950
+Hydroxymalonyl-CoA
Step 12M11
APK71_RS29955
+Hydroxymalonyl-CoA
{'Missing': ['AT']}
Step 13
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions13 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11537-1APK71_RS29920Loading
Alkylmalonyl-CoA
CC(C)(C)C(O)=O—
21537-2APK71_RS29920M1
1537-1;Malonyl-CoA
from: 1537-1
CC(C)(C)CCC(O)=O—
31537-3APK71_RS29920M2
1537-2;Malonyl-CoA
from: 1537-2
CC(C)(C)CC/C=C/C(O)=O{'Missing': ['DH']}
41537-4APK71_RS29920M3
1537-3;Malonyl-CoA
from: 1537-3
CC(CC/C=C/C=C\C(O)=O)(C)C—
51537-5APK71_RS29935M4
1537-4;Malonyl-CoA
from: 1537-4
CC(CC/C=C/C=C\CCC(O)=O)(C)C—
61537-6APK71_RS29940M5
1537-5;Malonyl-CoA
from: 1537-5
CC(CC/C=C/C=C\CC/C=C/C(O)=O)(C)C—
71537-7APK71_RS29940M6
1537-6;Malonyl-CoA
from: 1537-6
CC(CC/C=C/C=C\CC/C=C/C=C/C(O)=O)(C)C—
81537-8APK71_RS29945M7
1537-7;Methylmalonyl-CoA
from: 1537-7
CC(CC/C=C/C=C\CC/C=C/C=C/CC(C)C(O)=O)(C)C—
91537-9APK71_RS29945M8
1537-8;Hydroxymalonyl-CoA
from: 1537-8
CC(CC/C=C/C=C\CC/C=C/C=C/CC(C)C(O)C(O)C(O)=O)(C)C{'Missing': ['AT']}
101537-10APK71_RS29950M9
1537-9;Hydroxymalonyl-CoA
from: 1537-9
CC(CC/C=C/C=C\CC/C=C/C=C/CC(C)C(O)C(O)C(O)C(O)C(O)=O)(C)C—
111537-11APK71_RS29950M10
1537-10;Hydroxymalonyl-CoA
from: 1537-10
CC(CC/C=C/C=C\CC/C=C/C=C/CC(C)C(O)C(O)C(O)C(O)C(O)C(O)C(O)=O)(C)C—
121537-12APK71_RS29955M11
1537-11;Hydroxymalonyl-CoA
from: 1537-11
CC(CC/C=C/C=C\CC/C=C/C=C/CC(C)C(O)C(O)C(O)C(O)C(O)C(O)C(O)C(O)C(O)=O)(C)C{'Missing': ['AT']}
131537?—
1537-12
from: 1537-12
CC(C)(C)CC/C=C/C=C\CC/C=C/C=C/CC(C(C(C(C(C(C1OC(C(O)C1O)=O)O)O)O)O)O)C—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture