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BGC0001533PKS

Borrelidin

Producing organism
Streptomyces rochei
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces›Streptomyces rochei group
Biosynthetic class
PKS (Unknown)
Total steps
21
DOI
MIBiG entry
—
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borrelidin
C28H43NO6489.31 Da

Pathway Graphsteps arranged in biosynthetic order

21 steps · 20 edges
Step 1
Start
+5-oxo-pent-3-ene-…
Step 2
bor2N
Step 3
bor2N
Step 4
bor2M;bo2rC;bor2D
Step 5
bor2M;bor2C;bor2D
Step 6
bor2F
Step 7
bor2E
Step 8Load
bor2A1
Step 9M1
bor2A2
+Malonyl-CoA
Step 10M2
bor2A3
+Malonyl-CoA
Step 11M3
bor2A3
+Methylmalonyl-CoA
Step 12M4
bor2A4
+Methylmalonyl-CoA
Step 13M5
bor2A5
Iterative
Step 14M6
bor2A6
+Malonyl-CoA
Step 15TE
bor2A6
Step 16
bor2I
Step 17
bor2I;bor2K
Step 18
bor2J
Step 19
bor2I
Step 20
bor2I
Step 21
bor2I
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions21 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11533-1Start—
5-oxo-pent-3-ene-1,2,5-tricarboxylic acid
OC(CC(C(O)=O)/C=C\C(C(O)=O)=O)=O—
21533-2bor2N—
1533-1
from: 1533-1
OC(C/C=C/C=C(O)\C(O)=O)=O—
31533-3bor2N—
1533-2
from: 1533-2
OC(CC/C=C\C(C(O)=O)=O)=O—
41533-4bor2M;bo2rC;bor2D—
1533-3
from: 1533-3
OC(CCCCC(C(O)=O)=O)=O—
51533-5bor2M;bor2C;bor2D—
1533-4
from: 1533-4
OC(CCCCC(O)C(O)=O)=O—
61533-6bor2F—
1533-5
from: 1533-5
OC(CCCCC(O[R])C(O)=O)=O—
71533-7bor2E—
1533-6
from: 1533-6
O=C(O)[C@H]1[C@H](C(O)=O)CCC1—
81533-8bor2A1Loading
1533-7
from: 1533-7
O=C(O)[C@@]1([H])[C@H](C(O)=O)CCC1—
91533-9bor2A2M1
1533-8;Malonyl-CoA
from: 1533-8
O=C(O)[C@@H]1CCC[C@@]1([H])[C@@H](O)CC(O)=O—
101533-10bor2A3M2
1533-9;Malonyl-CoA
from: 1533-9
O=C(O)[C@@H]1CCC[C@@]1([H])[C@@H](O)C/C=C/C(O)=O—
111533-11bor2A3M3
1533-10;Methylmalonyl-CoA
from: 1533-10
O=C(O)[C@@H]1CCC[C@@]1([H])[C@@H](O)C/C=C/C=C(C(O)=O)\C—
121533-12bor2A4M4
1533-11;Methylmalonyl-CoA
from: 1533-11
O=C(O)[C@@H]1CCC[C@@]1([H])[C@@H](O)C/C=C/C=C([C@H](O)[C@H](C(O)=O)C)\C—
131533-13bor2A5M5
1533-12
from: 1533-12
O=C(O)[C@@H]1CCC[C@@]1([H])[C@@H](O)C/C=C/C=C([C@H](O)[C@H](C[C@H](C[C@H](C[C@H](C(O)=O)C)C)C)C)\C{'Iteration': [(['DH', 'KR']…
141533-14bor2A6M6
1533-13;Malonyl-CoA
from: 1533-13
O=C(O)[C@@H]1CCC[C@@]1([H])[C@@H](O)C/C=C/C=C([C@H](O)[C@H](C[C@H](C[C@H](C[C@H]([C@@H](O)CC(O)=O)C)C)C)C)\C—
151533-15bor2A6TE
1533-14
from: 1533-14
O=C(O)[C@@H]1CCC[C@]1([C@](O2)([H])C/C=C/C=C(C)\[C@H](C)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)C(O)CC2=O)[H]—
161533-16bor2I—
1533-15
from: 1533-15
O=C(O)[C@@H]1CCC[C@]1([C@](O2)([H])C/C=C/C=C(CO)\[C@H](C)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)C(O)CC2=O)[H]—
171533-17bor2I;bor2K—
1533-16
from: 1533-16
O=C(O)[C@@H]1CCC[C@]1([C@](O2)([H])C/C=C/C=C(C([H])=O)\[C@H](C)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)C(O)CC2=O)[H]—
181533-18bor2J—
1533-17
from: 1533-17
O=C(O)[C@@H]1CCC[C@]1([C@](O2)([H])C/C=C/C=C(CN)\[C@H](C)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)C(O)CC2=O)[H]—
191533-19bor2I—
1533-18
from: 1533-18
O=C(O)[C@@H]1CCC[C@]1([C@](O2)([H])C/C=C/C=C(CN(O)O)\[C@H](C)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)C(O)CC2=O)[H]—
201533-20bor2I—
1533-19
from: 1533-19
O=C(O)[C@@H]1CCC[C@]1([C@](O2)([H])C/C=C/C=C(/C=N/O)[C@H](C)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)C(O)CC2=O)[H]—
211533bor2I—
1533-20
from: 1533-20
O=C(O)[C@@H]1CCC[C@]1([C@](O2)([H])C/C=C/C=C(C#N)\[C@H](C)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)C(O)CC2=O)[H]—
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