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BGC0001523PKS

Azalomycin F3a

Producing organism
Streptomyces sp. 211726
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
22
DOI
MIBiG entry
View on MIBiG ↗
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azalomycin F3a
C55H93N3O171067.65 Da

Gene Cluster Map23 genes · 129,796 bp

20 kb129.8 kb visible · 129,796 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

22 steps · 21 edges
Step 1Load
azlA
Step 2M1;2
azlA
Iterative
Step 3M3
azlB
+Methylmalonyl-CoA
{'Missing': ['ER'], 'Domai…
Step 4M4
azlB
+Methylmalonyl-CoA
Step 5M5
azlB
+Malonyl-CoA
Step 6M6
azlC
+Methylmalonyl-CoA
Step 7M7
azlC
+Malonyl-CoA
Step 8M8
azlD
+Malonyl-CoA
Step 9M9
azlD
+Malonyl-CoA
Step 10M10
azlD
+Malonyl-CoA
Step 11M11
azlE
+Malonyl-CoA
Step 12M12
azlE
+Malonyl-CoA
Step 13M13
azlE
+Malonyl-CoA
Step 14M14
azlE
+Methylmalonyl-CoA
Step 15M15
azlE
+Malonyl-CoA
Step 16M16
azlF
+Methylmalonyl-CoA
Step 17M17
azlF
+Malonyl-CoA
Step 18M18
azlG
+Methylmalonyl-CoA
Step 19M19
azlG
+Malonyl-CoA
Step 20M20
azlH
+Methylmalonyl-CoA
Step 21TE
azlH
Step 22
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Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions22 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11523-1azlALoading
N=C(NCCCC(O)=O)N—
21523-2azlAM1;2
1523-1
from: 1523-1
N=C(NCCC/C=C/CCC(O)=O)N{'Iteration': [(['DH', 'KR']…
31523-3azlBM3
1523-2;Methylmalonyl-CoA
from: 1523-2
N=C(NCCC/C=C/CCCC(C)C(O)=O)N{'Missing': ['ER'], 'Domain_…
41523-4azlBM4
1523-3;Methylmalonyl-CoA
from: 1523-3
N=C(NCCC/C=C/CCCC(C)C(O)C(C)C(O)=O)N—
51523-5azlBM5
1523-4;Malonyl-CoA
from: 1523-4
N=C(NCCC/C=C/CCCC(C)C(O)C(C)/C=C/C(O)=O)N—
61523-6azlCM6
1523-5;Methylmalonyl-CoA
from: 1523-5
N=C(NCCC/C=C/CCCC(C)C(O)C(C)/C=C/C=C(C(O)=O)\C)N—
71523-7azlCM7
1523-6;Malonyl-CoA
from: 1523-6
N=C(NCCC/C=C/CCCC(C)C(O)C(C)/C=C/C=C(C(O)CC(O)=O)\C)N—
81523-8azlDM8
1523-7;Malonyl-CoA
from: 1523-7
N=C(NCCC/C=C/CCCC(C)C(O)C(C)/C=C/C=C(C(O)CC(O)CC(O)=O)\C)N—
91523-9azlDM9
1523-8;Malonyl-CoA
from: 1523-8
N=C(NCCC/C=C/CCCC(C)C(O)C(C)/C=C/C=C(C(O)CC(O)CC(O)CC(O)=O)\C)N—
101523-10azlDM10
1523-9;Malonyl-CoA
from: 1523-9
N=C(NCCC/C=C/CCCC(C)C(O)C(C)/C=C/C=C(C(O)CC(O)CC(O)CC(O)CC(O)=O)\C)N—
111523-11azlEM11
1523-10;Malonyl-CoA
from: 1523-10
N=C(NCCC/C=C/CCCC(C)C(O)C(C)/C=C/C=C(C(O)CC(O)CC(O)CC(O)CC(O)CC(O)=O)\C)N—
121523-12azlEM12
1523-11;Malonyl-CoA
from: 1523-11
N=C(NCCC/C=C/CCCC(C)C(O)C(C)/C=C/C=C(C(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(O)=O)\C)N—
131523-13azlEM13
1523-12;Malonyl-CoA
from: 1523-12
N=C(NCCC/C=C/CCCC(C)C(O)C(C)/C=C/C=C(C(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(CC(O)=O)=O)\C)N—
141523-14azlEM14
1523-13;Methylmalonyl-CoA
from: 1523-13
N=C(NCCC/C=C/CCCC(C)C(O)C(C)/C=C/C=C(C(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(CC(O)C(C)C(O)=O)=O)\C)N—
151523-15azlEM15
1523-14;Malonyl-CoA
from: 1523-14
N=C(NCCC/C=C/CCCC(C)C(O)C(C)/C=C/C=C(C(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(CC(O)C(C)CCC(O)=O)=O)\C)N—
161523-16azlFM16
1523-15;Methylmalonyl-CoA
from: 1523-15
N=C(NCCC/C=C/CCCC(C)C(O)C(C)/C=C/C=C(C(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(CC(O)C(C)CCC(O)C(C)C(O)=O)=O)\C)N—
171523-17azlFM17
1523-16;Malonyl-CoA
from: 1523-16
N=C(NCCC/C=C/CCCC(C)C(O)C(C)/C=C/C=C(C(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(CC(O)C(C)CCC(O)C(C)C(O)CC(O)=O)=O)\C)N—
181523-18azlGM18
1523-17;Methylmalonyl-CoA
from: 1523-17
N=C(NCCC/C=C/CCCC(C)C(O)C(C)/C=C/C=C(C(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(CC(O)C(C)CCC(O)C(C)C(O)CC(O)C(C)C(O)=O)=O)\C)N—
191523-19azlGM19
1523-18;Malonyl-CoA
from: 1523-18
N=C(NCCC/C=C/CCCC(C)C(O)C(C)/C=C/C=C(C(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(CC(O)C(C)CCC(O)C(C)C(O)CC(O)C(C)/C=C/C(O)=O)=O)\C)N—
201523-20azlHM20
1523-19;Methylmalonyl-CoA
from: 1523-19
N=C(NCCC/C=C/CCCC(C)C(O)C(C)/C=C/C=C(C(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(CC(O)C(C)CCC(O)C(C)C(O)CC(O)C(C)/C=C/C=C(C)/C(O)=O)=O)\C)N—
211523-21azlHTE
1523-20
from: 1523-20
OC(CC(O)C(C)/C=C/C=C1\C)C(C)C(O)CCC(C)C(O)CC(C(O)C(O)C2)(O)OC2CC(O)CC(O)CC(O)CC(O)/C(C)=C/C=C/C(C)C(C(C)CCC/C=C/CCCNC(N)=N)OC1=O—
221523?—
1523-21
from: 1523-21
OC(CC(O)C(C)/C=C/C=C1\C)C(C)C(O)CCC(C)C(O)CC(C(O)C(O)C2)(O)OC2CC(OC(CC(O)=O)=O)CC(O)CC(O)CC(O)/C(C)=C/C=C/C(C)C(C(C)CCC/C=C/CCCNC(N)=N)OC1=O—
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