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BGC0001522PKS

Auroramycin

Producing organism
Streptomyces filamentosus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
15
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map67 genes · 126,292 bp

20 kb126.3 kb visible · 126,292 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
AmTAminotransferase I/II
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

15 steps · 14 edges
Step 1Load
AWR88405.1
Step 13
Start
Step 14
Start
Step 2M1
AWR88405.1
+Methylmalonyl-CoA
Step 3M2
AWR88405.1
+Malonyl-CoA
Step 4M3
AWR88404.1
+Methylmalonyl-CoA
Step 5M4
AWR88404.1
+Malonyl-CoA
Step 6M5
AWR88404.1
+Malonyl-CoA
Step 7M6
AWR88398.1
+Methylmalonyl-CoA
Step 8M7
AWR88399.1
+Malonyl-CoA
Step 9M8
AWR88399.1
+Malonyl-CoA
Step 10M9
AWR88393.1
+Methylmalonyl-CoA
Step 11M10
AWR88393.1
+Isobutylmalonyl-C…
Step 12TE
AWR88393.1, (AWR88406.1…
Step 15
AWR88414.1, AWR88422.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions15 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11522-1AWR88405.1Loading
O=C([R])N[C@@H](C)CC(O)=O—
21522-2AWR88405.1M1
1522-1;Methylmalonyl-CoA
from: 1522-1
O=C([R])N[C@@H](C)C/C=C(C)/C(O)=O—
31522-3AWR88405.1M2
1522-2;Malonyl-CoA
from: 1522-2
O=C([R])N[C@@H](C)C/C=C(C)/C=C/C(O)=O—
41522-4AWR88404.1M3
1522-3;Methylmalonyl-CoA
from: 1522-3
O=C([R])N[C@@H](C)C/C=C(C)/C=C/C=C(C(O)=O)\C—
51522-5AWR88404.1M4
1522-4;Malonyl-CoA
from: 1522-4
O=C([R])N[C@@H](C)C/C=C(C)/C=C/C=C(/C=C/C(O)=O)C—
61522-6AWR88404.1M5
1522-5;Malonyl-CoA
from: 1522-5
O=C([R])N[C@@H](C)C/C=C(C)/C=C/C=C(/C=C/C=C\C(O)=O)C—
71522-7AWR88398.1M6
1522-6;Methylmalonyl-CoA
from: 1522-6
O=C([R])N[C@@H](C)C/C=C(C)/C=C/C=C(/C=C/C=C\[C@H](O)[C@H](C(O)=O)C)C—
81522-8AWR88399.1M7
1522-7;Malonyl-CoA
from: 1522-7
O=C([R])N[C@@H](C)C/C=C(C)/C=C/C=C(/C=C/C=C\[C@H](O)[C@H](/C=C/C(O)=O)C)C—
91522-9AWR88399.1M8
1522-8;Malonyl-CoA
from: 1522-8
O=C([R])N[C@@H](C)C/C=C(C)/C=C/C=C(/C=C/C=C\[C@H](O)[C@H](/C=C/C=C/C(O)=O)C)C—
101522-10AWR88393.1M9
1522-9;Methylmalonyl-CoA
from: 1522-9
O=C([R])N[C@@H](C)C/C=C(C)/C=C/C=C(/C=C/C=C\[C@H](O)[C@H](/C=C/C=C/C=C(C(O)=O)\C)C)C—
111522-11AWR88393.1M10
1522-10;Isobutylmalonyl-CoA
from: 1522-10
O=C([R])N[C@@H](C)C/C=C(C)/C=C/C=C(/C=C/C=C\[C@H](O)[C@H](/C=C/C=C/C=C(CC(C(O)=O)CC(C)C)\C)C)C—
121522-12AWR88393.1, (AWR88406.1, AWR88413.1)TE
1522-11
from: 1522-11
CC(/C=C/C=C\[C@H](O)[C@@](O)(C)/C=C/C=C/C=C(C)/C=C1\CC(C)C)=C\C=C\C(C)=C\C[C@H](C)NC1=O—
131522-13Start—
C[C@]1(O)[C@H](N(C)C)[C@@H](C)O[C@@H](O)C1—
141522-14Start—
O[C@H]1[C@H](O)CO[C@@H](O)[C@@H]1N—
151522AWR88414.1, AWR88422.1—
1522-12;1522-13;1522-14
from: 1522-12, 1522-13, 1522-14
CC(/C=C/C=C\[C@H](O[C@@H]1OC[C@@H](O[C@H]2C[C@@](C)(O)[C@H](N(C)C)[C@@H](C)O2)[C@H](O)[C@H]1N)[C@@](O)(C)/C=C/C=C/C=C(C)/C=C3\CC(C)C)=C\C=C\C(C)=C\C[C@H](C)NC3=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture