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BGC0001519Hybrid

Aurantimycin A

Producing organism
Streptomyces aurantiacus JA 4570
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces›Streptomyces aurantiacus group
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
22
DOI
—
MIBiG entry
View on MIBiG ↗
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aurantimycin A
C38H64N8O14856.45 Da

Gene Cluster Map34 genes · 64,790 bp

AAEAAAAKSKSKSERKSA10 kb64.8 kb visible · 64,790 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
EEpimerization (E)
DnDocking N-term
DcDocking C-term
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

22 steps · 22 edges
Step 1Load
STRAU_0344
+Methylmalonyl-CoA
Step 5
Start
+L-Leucine
Step 11
Start
+L-Alanine/L-Serine
Step 2M1
STRAU_0345
+2-(2-methylpropyl…
Inactive: DH
Step 6
STRAU_0332;(STRAU_0333/…
Step 12
STRAU_0332;(STRAU_0333/…
Step 3M2
STRAU_0346
+Malonyl-CoA
Step 7
STRAU_0342
Step 13
STRAU_0334
Step 4M3
STRAU_0347
+Methylmalonyl-CoA
Step 8TE
STRAU_0343
Step 14TE
STRAU_0343
Step 15TE
STRAU_0343
Step 16TE
STRAU_0343
Step 9M4
STRAU_0349
Step 10M5
STRAU_0335
+L-Ornithine
Step 17M6
STRAU_0335
Step 18M7
STRAU_0336
+Glycine
Step 19M8
STRAU_0336
+L-Ornithine
Step 20M9
STRAU_0337
Step 21TE
STRAU_0337
Step 22
STRAU_0323
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions22 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11519-1STRAU_0344Loading
Methylmalonyl-CoA
O=C(O)CC—
21519-2STRAU_0345M1
1519-1;2-(2-methylpropyl) malonyl-CoA
from: 1519-1
O=C(O)C(CC(C)C)C(CC)O{'Inactive': ['DH']}
31519-3STRAU_0346M2
1519-2;Malonyl-CoA
from: 1519-2
O=C(O)CCC(CC(C)C)C(CC)O—
41519-4STRAU_0347M3
1519-3;Methylmalonyl-CoA
from: 1519-3
O=C(O)C(C)C(CCC(CC(C)C)C(CC)O)=O—
51519-5Start—
L-Leucine
NC(C(O)=O)CC(C)C—
61519-6STRAU_0332;(STRAU_0333/STRAU_0341)—
1519-5
from: 1519-5
O=C(O)C(N)CC(C)C—
71519-7STRAU_0342—
1519-6
from: 1519-6
O=C(O)C(N)C(C(C)C)O—
81519-8STRAU_0343TE
1519-7
from: 1519-7
O=C(O)C(N)C(C(C)C)O—
91519-9STRAU_0349M4
1519-4;1519-8
from: 1519-4, 1519-8
OC(C(C(C(C)C)O)NC(C(C1(OC(C(CC1)CC(C)C)CC)O)C)=O)=O—
101519-10STRAU_0335M5
1519-9;L-Ornithine
from: 1519-9
O=C(C(C(O)C(C)C)NC(C(C1(OC(C(CC1)CC(C)C)CC)O)C)=O)C2CCCCC2C(O)=O—
111519-11Start—
L-Alanine/L-Serine
[R]C(C(O)=O)N—
121519-12STRAU_0332;(STRAU_0333/STRAU_0341)—
1519-11
from: 1519-11
[R]C(C(O)=O)N—
131519-13STRAU_0334—
1519-12
from: 1519-12
[R]C(C(O)=O)NC—
141519-14STRAU_0343TE
1519-13
from: 1519-13
[R]C(C(O)=O)NC—
151519-15STRAU_0343TE
1519-13
from: 1519-13
CC(C(O)=O)NC—
161519-16STRAU_0343TE
1519-13
from: 1519-13
O=C(O)C(NC)COC—
171519-17STRAU_0335M6
1519-10;1519-16
from: 1519-10, 1519-16
O=C(N(O)C(COC)C(O)=O)C1CCCCC1C(C(C(O)C(C)C)NC(C(C2(OC(C(CC2)CC(C)C)CC)O)C)=O)=O—
181519-18STRAU_0336M7
1519-17;Glycine
from: 1519-17
O=C(N(O)C(COC)C(NCC(O)=O)=O)C1CCCCC1C(C(C(O)C(C)C)NC(C(C2(OC(C(CC2)CC(C)C)CC)O)C)=O)=O—
191519-19STRAU_0336M8
1519-18;L-Ornithine
from: 1519-18
O=C(N(O)C(COC)C(NCC(N1NCCCC1C(O)=O)=O)=O)C2CCCCC2C(C(C(O)C(C)C)NC(C(C3(OC(C(CC3)CC(C)C)CC)O)C)=O)=O—
201519-20STRAU_0337M9
1519-19;1519-15
from: 1519-19, 1519-15
O=C(N(O)C(COC)C(NCC(N1NCCCC1C(N(C(C(O)=O)C)O)=O)=O)=O)C2CCCCC2C(C(C(O)C(C)C)NC(C(C3(OC(C(CC3)CC(C)C)CC)O)C)=O)=O—
211519-21STRAU_0337TE
1519-20
from: 1519-20
O=C(CNC(C(COC)N(O)C(C(CCCN1)N1C(C(NC(C(C2(O)CCC(CC(C)C)C(CC)O2)C)=O)C(C(C)C)O3)=O)=O)=O)N4NCCCC4C(N(O)C(C)C3=O)=O—
221519STRAU_0323—
1519-21
from: 1519-21
O=C(CNC(C(COC)N(O)C(C(CCCN1)N1C(C(NC(C(C)(O)C2(O)CCC(CC(C)C)C(CC)O2)=O)C(C(C)C)O3)=O)=O)=O)N4NCCCC4C(N(O)C(C)C3=O)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture