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BGC0001511PKS

Ansamitocin P-3

Producing organism
Actinosynnema pretiosum subsp. pretiosum
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Actinosynnema
Biosynthetic class
PKS (Unknown)
Total steps
28
DOI
MIBiG entry
—
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ansamitocin P-3
C32H43ClN2O9634.27 Da

Pathway Graphsteps arranged in biosynthetic order

28 steps · 25 edges
Step 1
Start
+Kanosamine
Step 5
Start
+PEP
Step 13
Start
+1,3-P2-D-glycolate
Step 2
AQZ37109.1;AQZ37110.1
Step 6
?
Step 14
AQZ37103.1;AQZ37101.1
Step 3
?
Step 7
?
Step 15
AQZ37104.1
Step 4
?
Step 8
AQZ37111.1
Step 16
AQZ37100.1/AQZ37102.1
Step 9
AQZ37112.1
Step 17M3
AQZ37114.1
Step 10Load
AQZ37113.1
Step 18M4
AQZ37114.1
+Malonyl-CoA
Step 11M1
AQZ37113.1
+Methylmalonyl-CoA
Step 19M5
AQZ37094.1
+Methylmalonyl-CoA
Step 12M2
AQZ37113.1
+Malonyl-CoA
Step 20M6
AQZ37095.1
+Methylmalonyl-CoA
Step 21M7
AQZ37095.1
+Malonyl-CoA
Step 22
AQZ37096.1
Step 23
AQZ37099.1
Step 24
AQZ37092.1
Step 25
AQZ37108.1
Step 26
AQZ37106.1
Step 27
AQZ37098.1
Step 28
AQZ37097.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions28 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11511-1Start—
Kanosamine
OC[C@H]1O[C@H](O)[C@H](O)[C@@H](N)[C@@H]1O—
21511-2AQZ37109.1;AQZ37110.1—
20-1
from: 20-1
O[C@H]1[C@H](N)[C@@H](O)[C@@H](O)O[C@@H]1CO[R]—
31511-3?—
20-2
from: 20-2
OC1(CO)C(N)C(O)C(CO[R])C1—
41511-4?—
20-3
from: 20-3
O[C@]([H])([C@@]([H])(CO[R])O)C=N—
51511-5Start—
PEP
C=C(C(O)=O)O[R]—
61511-6?—
20-4;20-5
from: 20-4, 20-5
O[C@]([H])([C@@]([H])(CO[R])O)[C@@](N)([H])C([H])([H])C(C(O)=O)=O—
71511-7?—
20-6
from: 20-6
O=C1C[C@@](O)(C(O)=O)C[C@@H](N)[C@@H]1O—
81511-8AQZ37111.1—
20-7
from: 20-7
C/C(C(O)=O)=C\C([C@@H](O)CN)=O—
91511-9AQZ37112.1—
20-8
from: 20-8
OC(C1=CC(N)=CC(O)=C1)=O—
101511-10AQZ37113.1Loading
20-9
from: 20-9
O=C(O)C1=CC(N)=CC(O)=C1—
111511-11AQZ37113.1M1
20-10;Methylmalonyl-CoA
from: 20-10
OC1=CC(CC(C)C(O)=O)=CC(N)=C1—
121511-12AQZ37113.1M2
20-11;Malonyl-CoA
from: 20-11
OC1=CC(CC(C)/C=C/C(O)=O)=CC(N)=C1—
131511-13Start—
1,3-P2-D-glycolate
[H]C(CO[R])(O)C(O[R])=O—
141511-14AQZ37103.1;AQZ37101.1—
20-13
from: 20-13
[H]C(CO)(O)C(O)=O—
151511-15AQZ37104.1—
20-14
from: 20-14
[H]C(CO)(OC)C(O)=O—
161511-16AQZ37100.1/AQZ37102.1—
20-15
from: 20-15
[H]C(C(O)=O)(OC)C(O)=O—
171511-17AQZ37114.1M3
20-12;20-16
from: 20-12, 20-16
OC1=CC(C/C(C)=C/C=C/C(OC)C(O)=O)=CC(N)=C1—
181511-18AQZ37114.1M4
20-17;Malonyl-CoA
from: 20-17
OC1=CC(C/C(C)=C/C=C/C(OC)C(CC(O)=O)=O)=CC(N)=C1—
191511-19AQZ37094.1M5
20-18;Methylmalonyl-CoA
from: 20-18
OC1=CC(C/C(C)=C/C=C/C(OC)C(CC(O)C(C)C(O)=O)=O)=CC(N)=C1—
201511-20AQZ37095.1M6
20-19;Methylmalonyl-CoA
from: 20-19
OC1=CC(C/C(C)=C/C=C/C(OC)C(CC(O)C(C)/C=C(C)/C(O)=O)=O)=CC(N)=C1—
211511-21AQZ37095.1M7
20-20;Malonyl-CoA
from: 20-20
OC1=CC(C/C(C)=C/C=C/C(OC)C(CC(O)C(C)/C=C(C)/C(O)CC(O)=O)=O)=CC(N)=C1—
221511-22AQZ37096.1—
20-21
from: 20-21
C/C(CC1=CC(NC(C[C@H](O)/C(C)=C/[C@@H]([C@H](C2)O)C)=O)=CC(O)=C1)=C\C=C\C(OC)C2=O—
231511-23AQZ37099.1—
20-22
from: 20-22
C/C(CC1=CC(NC(C[C@H](O)/C(C)=C/[C@@H]([C@H](C2)O)C)=O)=C(Cl)C(O)=C1)=C\C=C\C(OC)C2=O—
241511-24AQZ37092.1—
20-23
from: 20-23
C/C(CC1=CC(NC(C[C@H](O)/C(C)=C/[C@@H]([C@H](C2)O)C)=O)=C(Cl)C(OC)=C1)=C\C=C\C(OC)C2=O—
251511-25AQZ37108.1—
20-24
from: 20-24
C/C(CC1=CC(N2)=C(Cl)C(OC)=C1)=C\C=C\C(OC)[C@@](N3)(O)C[C@H](OC3=O)[C@@H](C)/C=C(C)/[C@@H](O)CC2=O—
261511-26AQZ37106.1—
20-25
from: 20-25
C/C(CC1=CC(N2)=C(Cl)C(OC)=C1)=C\C=C\C(OC)[C@@](N3)(O)C[C@H](OC3=O)[C@@H](C)/C=C(C)/[C@@H](OC(C(C)C)=O)CC2=O—
271511-27AQZ37098.1—
20-26
from: 20-26
C/C(CC1=CC(N2)=C(Cl)C(OC)=C1)=C\C=C\C(OC)[C@@](N3)(O)C[C@H](OC3=O)[C@@H](C)[C@@]4([H])O[C@@](C)4[C@@H](OC(C(C)C)=O)CC2=O—
281511AQZ37097.1—
20-27
from: 20-27
C/C(CC1=CC(N2C)=C(Cl)C(OC)=C1)=C\C=C\C(OC)[C@@](N3)(O)C[C@H](OC3=O)[C@@H](C)[C@@]4([H])O[C@@](C)4[C@@H](OC(C(C)C)=O)CC2=O—
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