NPdia
← Back to Repository
BGC0001503PKS

Amycolamycin A;Amycolamycin B

Producing organism
Amycolatopsis sp
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Amycolatopsis
Biosynthetic class
PKS (Unknown)
Total steps
21
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map70 genes · 89,350 bp

KSKS20 kb89.3 kb visible · 89,350 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

21 steps · 20 edges
Step 1
Start
Step 6
ATV95616.1
+Acetyl-CoA, Malonyl-CoA
Step 9
Start
+L-Tyrosine
Step 17
ATV95639.1, ATV95640.1,…
+Acetyl-CoA, Malonyl-CoA
Step 2
ATV95598.1
Step 7
ATV95617.1
Step 10
?
Step 3
ATV95599.1
Step 8
ATV95615.1
Step 11
ATV95608.1
Step 4
ATV95600.1
Step 12
ATV95610.1
Step 5
ATV95593.1
Step 13
ATV95603.1
Step 14
ATV95604.1
Step 15
ATV95602.1
Step 16
ATV95606.1
Step 18
ATV95601.1, ATV95596.1,…
Step 19
?
Step 20
?
Step 21
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions21 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11503-1Start—
O[C@H]1[C@H](O)[C@@H](O)[C@@H]([R])O[C@@H]1CO—
21503-2ATV95598.1—
1503-1
from: 1503-1
O[C@H]1[C@H](O)[C@@H](O)[C@@H]([R])O[C@@H]1C(O)=O—
31503-3ATV95599.1—
1503-2
from: 1503-2
O[C@H]([C@@H](O)[C@@H]([R])OC1)C1=O—
41503-4ATV95600.1—
1503-3
from: 1503-3
C[C@@]([C@@H](O)[C@@H]([R])OC1)(O)C1=O—
51503-5ATV95593.1—
1503-4
from: 1503-4
C[C@@]1(O)[C@H](N)CO[C@H]([R])[C@@H]1O—
61503-6ATV95616.1—
Acetyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA
CC1=CC=CC(O)=C1C(O)=O—
71503-7ATV95617.1—
1503-6
from: 1503-6
CC1=CC=CC(O)=C1C([R])=O—
81503-8ATV95615.1—
1503-7
from: 1503-7
CC1=CC=C(C)C(O)=C1C([R])=O—
91503-9Start—
L-Tyrosine
OC1=CC=C(CC(N)C(O)=O)C=C1—
101503-10?—
1503-9
from: 1503-9
OC1=CC=C(CC(C(O)=O)=O)C=C1—
111503-11ATV95608.1—
1503-10
from: 1503-10
OC1=CC=C(C(O)C(O)=O)C=C1—
121503-12ATV95610.1—
1503-11
from: 1503-11
OC1=CC=C(C(O)C(O)=O)C=C1—
131503-13ATV95603.1—
1503-12
from: 1503-12
OC1=CC=C(C(O)C(O)=O)C=C1O—
141503-14ATV95604.1—
1503-13
from: 1503-13
OC1=C(O)C=C(C(O)C(O)=O)C=C1O—
151503-15ATV95602.1—
1503-14
from: 1503-14
OC(C(O)C1=CC(O)=C(OC)C(OC)=C1)=O—
161503-16ATV95606.1—
1503-15
from: 1503-15
OC(C(O)C1=C(Cl)C(O)=C(OC)C(OC)=C1)=O—
171503-17ATV95639.1, ATV95640.1, ATV95641.1, ATV95642.1, ATV95643.1, ATV95644.1, ATV95645.1, ATV95646.1, ATV95647.1, ATV95648.1, ATV95649.1, ATV95637.1, ATV95638.1, ATV95595.1, ATV95595.1—
Acetyl-CoA;Malonyl-CoA;?
O[C@@H]1CC=C2[C@@]1(O3)[C@@H]3C#C/C=C([C@H](O4)[C@@H]4O)\C#C2—
181503-18ATV95601.1, ATV95596.1, ATV95607.1—
1503-5;1503-8;1503-16;1503-7
from: 1503-5, 1503-8, 1503-16, 1503-7
OC1([H])CC=C2C1(O[C@@H]3[C@@H](O)[C@@](C)(O)[C@@H](NC(C4=C(C)C=CC(C)=C4O)=O)CO3)C5C#C/C=C([C@@](O6)([H])C6([H])OC([C@@]([R1])([R2])C7=CC(OC)=C(C(O5)=C7Cl)OC)=O)\C#C2—
191503-19?—
1503-18
from: 1503-18
OC1([H])CC=C2C1(O[C@@H]3[C@@H](O)[C@@](C)(O)[C@@H](NC(C4=C(C)C=CC(C)=C4O)=O)CO3)C5C(C=C6)=C2C=C6[C@@](O7)([H])C7([H])OC([C@@]([R1])([R2])C8=CC(OC)=C(C(O5)=C8Cl)OC)=O—
201503(1)?—
1503-18
from: 1503-18
OC1([H])CC=C2C1(O[C@@H]3[C@@H](O)[C@@](C)(O)[C@@H](NC(C4=C(C)C=CC(C)=C4O)=O)CO3)C5C(C=C6)=C2C=C6[C@@](O7)([H])C7([H])OC([C@@](O)([H])C8=CC(OC)=C(C(O5)=C8Cl)OC)=O—
211503(2)?—
1503-18
from: 1503-18
OC1([H])CC=C2C1(O[C@@H]3[C@@H](O)[C@@](C)(O)[C@@H](NC(C4=C(C)C=CC(C)=C4O)=O)CO3)C5C(C=C6)=C2C=C6[C@@](O7)([H])C7([H])OC([C@@]([H])(O)C8=CC(OC)=C(C(O5)=C8Cl)OC)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture