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BGC0001495PKS

Actinoallolide A

Producing organism
Actinoallomurus fulvus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Streptosporangiales›Thermomonosporaceae›Actinoallomurus
Biosynthetic class
PKS (Unknown)
Total steps
14
DOI
MIBiG entry
View on MIBiG ↗
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actinoallolide A
C32H52O8564.37 Da

Gene Cluster Map10 genes · 56,721 bp

ERKSATKSATKSATKSATKSATERKSATKSATKSATKSATERKSATKSAT10 kb56.7 kb visible · 56,721 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

14 steps · 13 edges
Step 1Load
aalA1
+Methylmalonyl-CoA
Step 2M1
aalA1
+Methylmalonyl-CoA
Inactive: KR
Step 3M2
aalA1
+Methylmalonyl-CoA
Step 4M3
aalA1
+Methylmalonyl-CoA
Step 5M4
aalA2
+Methylmalonyl-CoA
Step 6M5
aalA2
+Methylmalonyl-CoA
Step 7M6
aalA2
+Malonyl-CoA
Step 8M7
aalA2
+Methylmalonyl-CoA
Step 9M8
aalA3
+Methylmalonyl-CoA
Step 10M9
aalA3
+Ethylmalonyl-CoA
Step 11M10
aalA3
+Malonyl-CoA
Step 12TE
aalA3
Step 13
aalB
Step 14
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions14 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11495-1aalA1Loading
Methylmalonyl-CoA
O=C(O)CC—
21495-2aalA1M1
1495-1;Methylmalonyl-CoA
from: 1495-1
O=C([C@H](C(O)=O)C)CC{'Inactive': ['KR']}
31495-3aalA1M2
1495-2;Methylmalonyl-CoA
from: 1495-2
O=C([C@H]([C@H](O)[C@H](C(O)=O)C)C)CC—
41495-4aalA1M3
1495-3;Methylmalonyl-CoA
from: 1495-3
O=C([C@H]([C@H](O)[C@H](/C=C(C(O)=O)\C)C)C)CC—
51495-5aalA2M4
1495-4;Methylmalonyl-CoA
from: 1495-4
O=C([C@H]([C@H](O)[C@H](/C=C(C[C@@H](C)C(O)=O)\C)C)C)CC—
61495-6aalA2M5
1495-5;Methylmalonyl-CoA
from: 1495-5
O=C([C@H]([C@H](O)[C@H](/C=C(C[C@@H](C)[C@@H](O)[C@@H](C)C(O)=O)\C)C)C)CC—
71495-7aalA2M6
1495-6;Malonyl-CoA
from: 1495-6
O=C([C@H]([C@H](O)[C@H](/C=C(C[C@@H](C)[C@@H](O)[C@@H](C)[C@H](O)CC(O)=O)\C)C)C)CC—
81495-8aalA2M7
1495-7;Methylmalonyl-CoA
from: 1495-7
O=C([C@H]([C@H](O)[C@H](/C=C(C[C@@H](C)[C@@H](O)[C@@H](C)[C@H](O)C/C=C(C)/C(O)=O)\C)C)C)CC—
91495-9aalA3M8
1495-8;Methylmalonyl-CoA
from: 1495-8
O=C([C@H]([C@H](O)[C@H](/C=C(C[C@@H](C)[C@@H](O)[C@@H](C)[C@H](O)C/C=C(C)/C[C@@H](C)C(O)=O)\C)C)C)CC—
101495-10aalA3M9
1495-9;Ethylmalonyl-CoA
from: 1495-9
O=C([C@H]([C@H](O)[C@H](/C=C(C[C@@H](C)[C@@H](O)[C@@H](C)[C@H](O)C/C=C(C)/C[C@@H](C)C([C@@H](CC)C(O)=O)=O)\C)C)C)CC—
111495-11aalA3M10
1495-10;Malonyl-CoA
from: 1495-10
O=C([C@H]([C@H](O)[C@H](/C=C(C[C@@H](C)[C@@H](O)[C@@H](C)[C@H](O)C/C=C(C)/C[C@@H](C)C([C@@H](CC)C(CC(O)=O)=O)=O)\C)C)C)CC—
121495-12aalA3TE
1495-11
from: 1495-11
O=C([C@H]([C@H](O)[C@H](/C=C(C[C@@H](C)[C@@H](O)[C@@H](C)[C@H]1C/C=C(C)/C[C@@H](C)C([C@@H](CC)C(CC(O1)=O)=O)=O)\C)C)C)CC—
131495-13aalB—
1495-12
from: 1495-12
O=C([C@H]([C@H](O)[C@H](/C=C(C[C@@H](C)[C@@H](O)[C@@H](C)[C@H]1C/C=C(C)/C[C@@](C)(O)C([C@@H](CC)C(CC(O1)=O)=O)=O)\C)C)C)CC—
141495?—
1495-13
from: 1495-13
O=C([C@H]([C@H](O)[C@H](/C=C(C[C@@H](C)[C@@H](O)[C@@H](C)[C@H]1C/C=C(C)/CC(C)(O2)C([C@@H](CC)C2(O)CC(O1)=O)=O)\C)C)C)CC—
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