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BGC0001491PKS

67-121C

Producing organism
Couchioplanes caeruleus subsp. caeruleus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Micromonosporales›Micromonosporaceae›Couchioplanes
Biosynthetic class
PKS (Unknown)
Total steps
31
DOI
MIBiG entry
View on MIBiG ↗
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67-121C
C65H98N2O241290.65 Da

Gene Cluster Map24 genes · 125,822 bp

20 kb125.8 kb visible · 125,822 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
AmTAminotransferase IV
AmTAminotransferase V

Pathway Graphsteps arranged in biosynthetic order

31 steps · 30 edges
Step 1
Start
+Chorismate
Step 28
Start
Step 29
Start
Step 2
BG844_00080
Step 3
BG844_00010
Step 4
?
Step 5Load
BG844_00075
Step 6M1
BG844_00075
+Malonyl-CoA
Step 7M2
BG844_00060
+Malonyl-CoA
Step 8M3
BG844_00060
+Methylmalonyl-CoA
Step 9M4
BG844_00060
+Methylmalonyl-CoA
Inactive: DH
Step 10M5
BG844_00065
+Malonyl-CoA
Step 11M6
BG844_00065
+Malonyl-CoA
Step 12M7
BG844_00065
+Malonyl-CoA
Step 13M8
BG844_00065
+Malonyl-CoA
Step 14M9
BG844_00065
+Malonyl-CoA
Step 15M10
BG844_00065
+Malonyl-CoA
Step 16M11
BG844_00045
+Malonyl-CoA
Step 17M12
BG844_00045
+Malonyl-CoA
Step 18M13
BG844_00045
+Methylmalonyl-CoA
Step 19M14
BG844_00045
+Malonyl-CoA
Step 20M15
BG844_00045
+Malonyl-CoA
Step 21M16
BG844_00045
+Malonyl-CoA
Step 22M17
BG844_00050
+Malonyl-CoA
Inactive: DH
Step 23M18
BG844_00050
+Malonyl-CoA
Inactive: DH
Step 24M19
BG844_00055
+Malonyl-CoA
Inactive: DH, KR
Step 25M20
BG844_00055
+Malonyl-CoA
Step 26M21
BG844_00055
+Malonyl-CoA
Inactive: DH
Step 27TE
BG844_00055
Step 30
?
Step 31
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions31 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11491-1Start—
Chorismate
OC(C1=C[C@@H](OC(C(O)=O)=C)[C@H](O)C=C1)=O—
21491-2BG844_00080—
1491-1
from: 1491-1
OC(C1=C[C@@H](OC(C(O)=O)=C)[C@H](N)C=C1)=O—
31491-3BG844_00010—
1491-2
from: 1491-2
OC(C1=CC(O)=C(N)C=C1)=O—
41491-4?—
1491-3
from: 1491-3
OC(C1=CC(O)=C(NC)C=C1)=O—
51491-5BG844_00075Loading
1491-4
from: 1491-4
OC(C1=CC=C(NC)C=C1)=O—
61491-6BG844_00075M1
1491-5;Malonyl-CoA
from: 1491-5
O=C(CC(O)=O)C1=CC=C(NC)C=C1—
71491-7BG844_00060M2
1491-6;Malonyl-CoA
from: 1491-6
O=C(CC(O)CC(O)=O)C1=CC=C(NC)C=C1—
81491-8BG844_00060M3
1491-7;Methylmalonyl-CoA
from: 1491-7
O=C(CC(O)CCC(C(O)=O)C)C1=CC=C(NC)C=C1—
91491-9BG844_00060M4
1491-8;Methylmalonyl-CoA
from: 1491-8
O=C(CC(O)CCC(C(O)C(C(O)=O)C)C)C1=CC=C(NC)C=C1{'Inactive': ['DH']}
101491-10BG844_00065M5
1491-9;Malonyl-CoA
from: 1491-9
O=C(O)/C=C/C(C)C(O)C(C)CCC(O)CC(C1=CC=C(NC)C=C1)=O—
111491-11BG844_00065M6
1491-10;Malonyl-CoA
from: 1491-10
O=C(O)/C=C/C=C/C(C)C(O)C(C)CCC(O)CC(C1=CC=C(NC)C=C1)=O—
121491-12BG844_00065M7
1491-11;Malonyl-CoA
from: 1491-11
O=C(O)/C=C/C=C/C=C/C(C)C(O)C(C)CCC(O)CC(C1=CC=C(NC)C=C1)=O—
131491-13BG844_00065M8
1491-12;Malonyl-CoA
from: 1491-12
O=C(O)/C=C/C=C/C=C/C=C/C(C)C(O)C(C)CCC(O)CC(C1=CC=C(NC)C=C1)=O—
141491-14BG844_00065M9
1491-13;Malonyl-CoA
from: 1491-13
O=C(O)/C=C/C=C/C=C/C=C/C=C/C(C)C(O)C(C)CCC(O)CC(C1=CC=C(NC)C=C1)=O—
151491-15BG844_00065M10
1491-14;Malonyl-CoA
from: 1491-14
O=C(O)/C=C/C=C/C=C/C=C/C=C/C=C/C(C)C(O)C(C)CCC(O)CC(C1=CC=C(NC)C=C1)=O—
161491-16BG844_00045M11
1491-15;Malonyl-CoA
from: 1491-15
O=C(O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(C)C(O)C(C)CCC(O)CC(C1=CC=C(NC)C=C1)=O—
171491-17BG844_00045M12
1491-16;Malonyl-CoA
from: 1491-16
O=C(O)CC(O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(C)C(O)C(C)CCC(O)CC(C1=CC=C(NC)C=C1)=O—
181491-18BG844_00045M13
1491-17;Methylmalonyl-CoA
from: 1491-17
OC(CC(O)C(C)C(O)=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(C)C(O)C(C)CCC(O)CC(C1=CC=C(NC)C=C1)=O—
191491-19BG844_00045M14
1491-18;Malonyl-CoA
from: 1491-18
OC(CC(O)C(C)C(O)CC(O)=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(C)C(O)C(C)CCC(O)CC(C1=CC=C(NC)C=C1)=O—
201491-20BG844_00045M15
1491-19;Malonyl-CoA
from: 1491-19
OC(CC(O)C(C)C(O)CC(CC(O)=O)=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(C)C(O)C(C)CCC(O)CC(C1=CC=C(NC)C=C1)=O—
211491-21BG844_00045M16
1491-20;Malonyl-CoA
from: 1491-20
OC(CC(O)C(C)C(O)CC(CC(O)CC(O)=O)=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(C)C(O)C(C)CCC(O)CC(C1=CC=C(NC)C=C1)=O—
221491-22BG844_00050M17
1491-21;Malonyl-CoA
from: 1491-21
OC(CC(O)C(C)C(O)CC(CC(O)CC(O)CC(O)=O)=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(C)C(O)C(C)CCC(O)CC(C1=CC=C(NC)C=C1)=O{'Inactive': ['DH']}
231491-23BG844_00050M18
1491-22;Malonyl-CoA
from: 1491-22
OC(CC(O)C(C)C(O)CC(CC(O)CC(O)CC(O)CC(O)=O)=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(C)C(O)C(C)CCC(O)CC(C1=CC=C(NC)C=C1)=O{'Inactive': ['DH']}
241491-24BG844_00055M19
1491-23;Malonyl-CoA
from: 1491-23
OC(CC(O)C(C)C(O)CC(CC(O)CC(O)CC(O)CC(CC(O)=O)=O)=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(C)C(O)C(C)CCC(O)CC(C1=CC=C(NC)C=C1)=O{'Inactive': ['DH', 'KR']}
251491-25BG844_00055M20
1491-24;Malonyl-CoA
from: 1491-24
OC(CC(O)C(C)C(O)CC(CC(O)CC(O)CC(O)CC(CC(O)CC(O)=O)=O)=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(C)C(O)C(C)CCC(O)CC(C1=CC=C(NC)C=C1)=O—
261491-26BG844_00055M21
1491-25;Malonyl-CoA
from: 1491-25
OC(CC(O)C(C)C(O)CC(CC(O)CC(O)CC(O)CC(CC(O)CC(O)CC(O)=O)=O)=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(C)C(O)C(C)CCC(O)CC(C1=CC=C(NC)C=C1)=O{'Inactive': ['DH']}
271491-27BG844_00055TE
1491-26
from: 1491-26
CC(C(OC(CC(O)CC(O)CC(CC(O)CC(O)CC(O)C1)=O)=O)C(C)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(O)CC(O)C(C)C(O)CC1=O)CCC(CC(C2=CC=C(C=C2)NC)=O)O—
281491-28Start—
O[C@H]1[C@@H](O)[C@@H](N)[C@H](O)[C@@H](C)O1—
291491-29Start—
O[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1—
301491-30?—
1491-27;1491-28
from: 1491-27, 1491-28
CC(C(OC(CC(O)CC(O)C1)=O)C(C)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(O[C@H]2[C@@H](O)[C@@H](N)[C@H](O)[C@@H](C)O2)CC(O3)C(C(O)=O)C(O)CC3(O)CC(O)CC(O)CC(O)CC1=O)CCC(CC(C4=CC=C(C=C4)NC)=O)O—
311491?—
1491-29;1491-30
from: 1491-29, 1491-30
CC(C(OC(CC(O)CC(O)C1)=O)C(C)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(O[C@H]2[C@@H](O)[C@@H](N)[C@H](O[C@H]3[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)[C@@H](C)O2)CC(O4)C(C(O)=O)C(O)CC4(O)CC(O)CC(O)CC(O)CC1=O)CCC(CC(C5=CC=C(C=C5)NC)=O)O—
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