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BGC0001477Hybrid

Lydicamycin

Producing organism
Streptomyces sp. ID38640
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Type I)
Total steps
25
DOI
MIBiG entry
View on MIBiG ↗
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lydicamycin
C47H74N4O10854.54 Da

Gene Cluster Map25 genes · 116,700 bp

20 kb116.7 kb visible · 116,700 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

25 steps · 24 edges
Step 1
Start
+Arginine
Step 2
AVV61994.1
Step 3
?
Step 4Load
AVV61977.1, AVV61989.1
Step 5M1
AVV61989.1
+Malonyl-CoA
Step 6M2
AVV61979.1
+Malonyl-CoA
Inactive: DH
Step 7M3
AVV61979.1
+Methylmalonyl-CoA
Step 8M4
AVV61980.1
+Malonyl-CoA
Inactive: DH
Step 9M5
AVV61980.1
+Malonyl-CoA
Step 10M6
AVV61980.1
+Methylmalonyl-CoA
Inactive: DH
Step 11M7
AVV61980.1
+Malonyl-CoA
Step 12M8
AVV61981.1
+Malonyl-CoA
Inactive: DH
Step 13M9
AVV61981.1
+Methylmalonyl-CoA
Step 14M10
AVV61982.1
+Methylmalonyl-CoA
Inactive: DH
Step 15M11
AVV61983.1
+Malonyl-CoA
Step 16M12
AVV61983.1
+Methylmalonyl-CoA
Step 17M13
AVV61983.1
+Malonyl-CoA
Step 18M14
AVV61984.1
+Malonyl-CoA
Step 19M15
AVV61984.1
+Malonyl-CoA
Step 20M16
AVV61985.1
+Methylmalonyl-CoA
Step 21M17
AVV61985.1
+Malonyl-CoA
Inactive: KR
Step 22M18
AVV61987.1
+Glycine
Step 23
?
Step 24
?
Step 25
AVV61990.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions25 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11477-1Start—
Arginine
N=C(NCCCC(N)C(O)=O)N—
21477-2AVV61994.1—
1477-1
from: 1477-1
N=C(NCCCC(C(O)=O)=O)N—
31477-3?—
1477-2
from: 1477-2
N=C(NCCCC([R])=O)N—
41477-4AVV61977.1, AVV61989.1Loading
1477-3
from: 1477-3
O=C(CCCNC(N)=N)O—
51477-5AVV61989.1M1
1477-4;Malonyl-CoA
from: 1477-4
NC(NCCC/C=C/C(O)=O)=N—
61477-6AVV61979.1M2
1477-5;Malonyl-CoA
from: 1477-5
NC(NCCC/C=C/C(O)CC(O)=O)=N{'Inactive': ['DH']}
71477-7AVV61979.1M3
1477-6;Methylmalonyl-CoA
from: 1477-6
NC(NCCC/C=C/C(O)C/C=C(C)/C(O)=O)=N—
81477-8AVV61980.1M4
1477-7;Malonyl-CoA
from: 1477-7
NC(NCCC/C=C/C(O)C/C=C(C)/C(O)CC(O)=O)=N{'Inactive': ['DH']}
91477-9AVV61980.1M5
1477-8;Malonyl-CoA
from: 1477-8
NC(NCCC/C=C/C(O)C/C=C(C)/C(O)C/C=C/C(O)=O)=N—
101477-10AVV61980.1M6
1477-9;Methylmalonyl-CoA
from: 1477-9
NC(NCCC/C=C/C(O)C/C=C(C)/C(O)C/C=C/C(O)C(C(O)=O)C)=N{'Inactive': ['DH']}
111477-11AVV61980.1M7
1477-10;Malonyl-CoA
from: 1477-10
NC(NCCC/C=C/C(O)C/C=C(C)/C(O)C/C=C/C(O)C(/C=C/C(O)=O)C)=N—
121477-12AVV61981.1M8
1477-11;Malonyl-CoA
from: 1477-11
NC(NCCC/C=C/C(O)C/C=C(C)/C(O)C/C=C/C(O)C(/C=C/C(O)CC(O)=O)C)=N{'Inactive': ['DH']}
131477-13AVV61981.1M9
1477-12;Methylmalonyl-CoA
from: 1477-12
NC(NCCC/C=C/C(O)C/C=C(C)/C(O)C/C=C/C(O)C(/C=C/C(O)C/C=C(C(O)=O)\C)C)=N—
141477-14AVV61982.1M10
1477-13;Methylmalonyl-CoA
from: 1477-13
NC(NCCC/C=C/C(O)C/C=C(C)/C(O)C/C=C/C(O)C(/C=C/C(O)C/C=C(C(O)C(C(O)=O)C)\C)C)=N{'Inactive': ['DH']}
151477-15AVV61983.1M11
1477-14;Malonyl-CoA
from: 1477-14
NC(NCCC/C=C/C(O)C/C=C(C)/C(O)C/C=C/C(O)C(/C=C/C(O)C/C=C(C(O)C(CCC(O)=O)C)\C)C)=N—
161477-16AVV61983.1M12
1477-15;Methylmalonyl-CoA
from: 1477-15
NC(NCCC/C=C/C(O)C/C=C(C)/C(O)C/C=C/C(O)C(/C=C/C(O)C/C=C(C(O)C(CC/C=C(C(O)=O)\C)C)\C)C)=N—
171477-17AVV61983.1M13
1477-16;Malonyl-CoA
from: 1477-16
NC(NCCC/C=C/C(O)C/C=C(C)/C(O)C/C=C/C(O)C(/C=C/C(O)C/C=C(C(O)C(CC/C=C(/C=C/C(O)=O)C)C)\C)C)=N—
181477-18AVV61984.1M14
1477-17;Malonyl-CoA
from: 1477-17
NC(NCCC/C=C/C(O)C/C=C(C)/C(O)C/C=C/C(O)C(/C=C/C(O)C/C=C(C(O)C(CC/C=C(/C=C/C(O)CC(O)=O)C)C)\C)C)=N—
191477-19AVV61984.1M15
1477-18;Malonyl-CoA
from: 1477-18
NC(NCCC/C=C/C(O)C/C=C(C)/C(O)C/C=C/C(O)C(/C=C/C(O)C/C=C(C(O)C(CC/C=C(/C=C/C(O)CCCC(O)=O)C)C)\C)C)=N—
201477-20AVV61985.1M16
1477-19;Methylmalonyl-CoA
from: 1477-19
NC(NCCC/C=C/C(O)C/C=C(C)/C(O)C/C=C/C(O)C(/C=C/C(O)C/C=C(C(O)C(CC/C=C(/C=C/C(O)CCC/C=C(C(O)=O)\C)C)C)\C)C)=N—
211477-21AVV61985.1M17
1477-20;Malonyl-CoA
from: 1477-20
NC(NCCC/C=C/C(O)C/C=C(C)/C(O)C/C=C/C(O)C(/C=C/C(O)C/C=C(C(O)C(CC/C=C(/C=C/C(O)CCC/C=C(C(CC(O)=O)=O)\C)C)C)\C)C)=N{'Inactive': ['KR']}
221477-22AVV61987.1M18
1477-21;Glycine
from: 1477-21
NC(NCCC/C=C/C(O)C/C=C(C)/C(O)C/C=C/C(O)C(/C=C/C(O)C/C=C(C(O)C(CC/C=C(/C=C/C(O)CCC/C=C(C(CC(NCC(O)=O)=O)=O)\C)C)C)\C)C)=N—
231477-23?—
1477-22
from: 1477-22
NC(NCCC/C=C/C(O)C/C=C(C)/C(O)C/C=C/C(O)C(/C=C/C(O)C/C=C(C(O)C(CC/C=C(/C=C/C(CCC/C=C(C)\C(C1C(NCC1=O)=O)=O)O)C)C)\C)C)=N—
241477-24?—
1477-23
from: 1477-23
OC(C/C=C(C)/C(O)C/C=C/C(O)C(/C=C/C(O)C/C=C(C(O)(C1CC1)C(CCC2=C(CC3C(CCCC3C(C)2C(C4=C(O)CNC4=O)=O)O)C)C)\C)C)CC5N(C(N)=N)CCC5—
251477AVV61990.1—
1477-24
from: 1477-24
OC(C/C=C(C)/C(O)C/C=C/C(O)C(/C=C/C(O)C/C=C(C(O)C(CCC1=C(CC2C(C(O)CCC2C(C)1C(C3=C(O)CNC3=O)=O)O)C)C)\C)C)CC4N(C(N)=N)CCC4—
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