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BGC0001457NRPS

Jomthonic acid A;Jomthonic acid B;Jomthonic acid C

Producing organism
Streptomyces caniferus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
7
DOI
MIBiG entry
View on MIBiG ↗
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C22H29NO5387.20 Da

Gene Cluster Map37 genes · 54,671 bp

KSATATKSATCA10 kb54.7 kb visible · 54,671 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
CnCOM N-term
TEThioesterase (TE)

Pathway Graphsteps arranged in biosynthetic order

7 steps · 6 edges
Step 1
ctg1_orf15
Inactive: AT2
Step 2
ctg1_orf16
+Malonyl-CoA
Step 3
ctg1_orf17
+β-Methylphenylala…
Step 4
?
+2-Hydroxy-3-methy…
Step 5
?
+2-Hydroxy-3-methy…
Step 6
?
+2-Hydroxy-3-methy…
Step 7
?
+3-Hydroxybutanoic…
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions7 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11457-1ctg1_orf15—
[R]/C(C(O)=O)=C\C{'Inactive': ['AT2']}
21457-2ctg1_orf16—
1457-1;Malonyl-CoA
from: 1457-1
[R]C(/C=C/C(O)=O)=C\C—
31457-3ctg1_orf17—
1457-2;β-Methylphenylalanine
from: 1457-2
[R]C(/C=C/C(NC(C(O)=O)C(C1=CC=CC=C1)C)=O)=C\C—
41457-4?—
1457-3;2-Hydroxy-3-methylbutyric acid
from: 1457-3
[R]C(/C=C/C(NC(C(OC(C(C(O)=O)C)C)=O)C(C1=CC=CC=C1)C)=O)=C\C—
51457(1)?—
1457-3;2-Hydroxy-3-methylbutyric acid
from: 1457-3
C/C=C/C=C/C(NC(C(OC(C(C(O)=O)C)C)=O)C(C1=CC=CC=C1)C)=O—
61457(2)?—
1457-3;2-Hydroxy-3-methylbutyric acid
from: 1457-3
CC(/C=C/C(NC(C(OC(C(C(O)=O)C)C)=O)C(C1=CC=CC=C1)C)=O)=C\C—
71457(3)?—
1457-3;3-Hydroxybutanoic acid
from: 1457-3
CC(/C=C/C(NC(C(OC(CC(O)=O)C)=O)C(C1=CC=CC=C1)C)=O)=C\C—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture