NPdia

BGC0001455Hybrid

Antimycin A1B

Producing organism: Streptomyces argillaceus
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: NRPS (Type I);PKS (Unknown)
Total steps: 11
DOI: 10.3762/bjoc.9.290
MIBiG entry: View on MIBiG ↗

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antimycin A1B

C₂₈H₄₀N₂O₉548.27 Da

Biosynthetic (core)

Biosynthetic (additional)

Regulatory

Other

Unknown

Domains

Ketosynthase (KS)

Acyltransferase (AT)

Enoylreductase (ER)

Ketoreductase (KR)

Condensation (C)

Adenylation (A)

Peptidyl carrier (PCP)

Acyl carrier (ACP)

Thioesterase (TE)

CoA-ligase (CAL)

Aminotransferase V

11 steps · 10 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`1455-1`	Start	—		`N[C@H](C(O)=O)CC1=CNC2=CC=CC=C21`	—
2	`1455-2`	antaN	—	1455-1 from: 1455-1	`O=C(C[C@H](N)C(O)=O)C1=CC=CC=C1NC=O`	—
3	`1455-3`	antaP	—	1455-2 from: 1455-2	`OC(C1=C(N)C=CC=C1)=O`	—
4	`1455-4`	antaF, antaG	—	1455-3 from: 1455-3	`OC(C1=C(N)C=CC=C1)=O`	—
5	`1455-5`	antaH, antaI, antaJ, antaK, antaL	—	1455-4 from: 1455-4	`OC(C12C(O2)=CC=CC1N)=O`	—
6	`1455-6`	?	—	1455-5 from: 1455-5	`OC(C1=C(O)C(N)=CC=C1)=O`	—
7	`1455-7`	antaC	M1	1455-6;Threonine from: 1455-6	`O=C(N[C@@H]([C@@H](C)O)C(O)=O)C1=C(O)C(N)=CC=C1`	—
8	`1455-8`	antaC	M2	1455-7;Pyruvate from: 1455-7	`O=C(N[C@@H]([C@@H](C)O)C(O[C@@H](C)C(O)=O)=O)C1=C(O)C(N)=CC=C1`	—
9	`1455-9`	antaD, antaE	M3	1455-8;Hexylmalonyl-CoA from: 1455-8	`O=C(N[C@@H]([C@@H](C)O)C(O[C@@H](C)C([C@@H](CCCCCC)C(O)=O)=O)=O)C1=C(O)C(N)=CC=C1`	—
10	`1455-10`	antaD	TE	1455-9 from: 1455-9	`NC1=CC=CC(C(NC([C@@H](C)OC([C@H](CCCCCC)[C@@H](O)[C@H](C)O2)=O)C2=O)=O)=C1O`	—
11	`1455`	antaB, antaO	—	1455-10;? from: 1455-10	`OC(C(NC=O)=CC=C1)=C1C(NC([C@@H](C)OC([C@H](CCCCCC)[C@@H](OC(CC(C)C)=O)[C@H](C)O2)=O)C2=O)=O`	—

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