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BGC0001443Hybrid

Matlystatin A

Producing organism
Actinomadura atramentaria DSM 43919
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Streptosporangiales›Thermomonosporaceae›Actinomadura
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
12
DOI
MIBiG entry
View on MIBiG ↗
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matlystatin A
C22H40N4O5440.30 Da

Gene Cluster Map18 genes · 24,158 bp

TEAKSATERCAC5 kb24.2 kb visible · 24,158 bp total
Biosynthetic (core)
Biosynthetic (additional)
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
EREnoylreductase (ER)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)

Pathway Graphsteps arranged in biosynthetic order

12 steps · 11 edges
Step 1
Start
Step 2
Start
+L-Ornithine
Step 11
Start
+N-acetylcysteine
Step 3
G339_RS0128940
Step 4
G339_RS35700
Step 5
G339_RS0128920;G339_RS0…
Step 6
G339_RS0128905;G339_RS3…
+Isoleucine
Step 7
G339_RS37205
+Methylmalonyl-CoA
Step 8TE
G339_RS0128880
Step 9
G339_RS35695
Step 10
G339_RS35695
Step 12
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions12 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11443-1Start—
[R]C([C@@H](CC(NO)=O)CCCCC)=O—
21443-2Start—
L-Ornithine
NCCC[C@H](N)C(O)=O—
31443-3G339_RS0128940—
1443-2
from: 1443-2
OC([C@@H](N)CCCNO)=O—
41443-4G339_RS35700—
1443-3
from: 1443-3
O=C(O)[C@@H]1CCCNN1—
51443-5G339_RS0128920;G339_RS0128910;G339_RS0128915—
1443-1;1443-4
from: 1443-1, 1443-4
O=C(C[C@@H](CCCCC)C(N1NCCC[C@H]1C(O)=O)=O)NO—
61443-6G339_RS0128905;G339_RS37205—
1443-5;Isoleucine
from: 1443-5
O=C(C[C@@H](CCCCC)C(N1NCCC[C@H]1C(N[C@H](C(O)=O)[C@@H](C)CC)=O)=O)NO—
71443-7G339_RS37205—
1443-6;Methylmalonyl-CoA
from: 1443-6
O=C(C[C@@H](CCCCC)C(N1NCCC[C@H]1C(N[C@H](C(C(C(O)=O)C)=O)[C@@H](C)CC)=O)=O)NO—
81443-8G339_RS0128880TE
1443-7
from: 1443-7
O=C(C[C@@H](CCCCC)C(N1NCCC[C@H]1C(N[C@H](C(C(C(O)=O)C)=O)[C@@H](C)CC)=O)=O)NO—
91443-9G339_RS35695—
1443-8
from: 1443-8
O=C(C[C@@H](CCCCC)C(N1NCCC[C@H]1C(N[C@H](/C([O-])=C/C([H])([H])[H])[C@@H](C)CC)=O)=O)NO—
101443-10G339_RS35695—
1443-9
from: 1443-9
O=C(C[C@@H](CCCCC)C(N1NCCC[C@H]1C(N[C@H](C(C=C)=O)[C@@H](C)CC)=O)=O)NO—
111443-11Start—
N-acetylcysteine
O=C([C@H](CS)NC(C)=O)O—
121443?—
1443-10;1443-11
from: 1443-10, 1443-11
O=C(C[C@@H](CCCCC)C(N1NCCC[C@H]1C(N[C@H](C(CCSC[C@@H](C(O)=O)NC(C)=O)=O)[C@@H](C)CC)=O)=O)NO—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture