NPdia
← Back to Repository
BGC0001442NRPS

Actinonin

Producing organism
Streptomyces sp. strain ATCC 14903
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
9
DOI
MIBiG entry
View on MIBiG ↗
Loading…
actinonin
C19H35N3O5385.26 Da

Gene Cluster Map18 genes · 32,297 bp

CATDERCA5 kb32.3 kb visible · 32,297 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
EREnoylreductase (ER)
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TDTerminal reductase

Pathway Graphsteps arranged in biosynthetic order

9 steps · 8 edges
Step 1
Start
+cis-oct-2-enoic a…
Step 2
actF
Step 3
actC
Step 4
actD
Step 5
actJ
Step 6
actI
Step 7
actG;actH
+Valine
Step 8
actE
+Proline
Step 9MTD
actE
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions9 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11442-1Start—
cis-oct-2-enoic acyl precursor
CCCCC/C=C/C([R])=O—
21442-2actF—
1442-1
from: 1442-1
O=C([C@@H](C([R])=O)CCCCCC)O—
31442-3actC—
1442-2
from: 1442-2
O=C([C@H](C([R])=O)CCCCCC)O—
41442-4actD—
1442-3
from: 1442-3
O=C(C[C@@H](CCCCC)C([R])=O)O—
51442-5actJ—
1442-4
from: 1442-4
O=C(C[C@@H](CCCCC)C([R])=O)N—
61442-6actI—
1442-5
from: 1442-5
ONC(C[C@@H](CCCCC)C([R])=O)=O—
71442-7actG;actH—
1442-6;Valine
from: 1442-6
CCCCC[C@H](CC(NO)=O)C(N[C@@H](C(C)C)C(O)=O)=O—
81442-8actE—
1442-7;Proline
from: 1442-7
CCCCC[C@H](CC(NO)=O)C(N[C@@H](C(C)C)C(N1[C@H](C(O)=O)CCC1)=O)=O—
91442actEMTD
1442-8
from: 1442-8
CCCCC[C@H](CC(NO)=O)C(N[C@@H](C(C)C)C(N1[C@H](CO)CCC1)=O)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture