NPdia

BGC0001435Hybrid

Ikarugamycin

Producing organism: Streptomyces sp. ZJ306
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: NRPS (Type I);PKS (Iterative type I)
Total steps: 8
DOI: 10.1002/anie.201402078
MIBiG entry: View on MIBiG ↗

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ikarugamycin

C₂₉H₃₈N₂O₄478.28 Da

Biosynthetic (core)

Biosynthetic (additional)

Regulatory

Unknown

Domains

Ketosynthase (KS)

Acyltransferase (AT)

Dehydratase (DH)

Enoylreductase (ER)

Ketoreductase (KR)

Acyl carrier (ACP)

Condensation (C)

Adenylation (A)

Acyl carrier (ACP)

Thioesterase (TE)

8 steps · 7 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions8 steps

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`1435-1`	AJD77023.1	—		`C/C=C/C=C/C=C/C=C/C(CC(O)=O)=O`	{'Iteration': [(['None'], 'M…
2	`1435-2`	AJD77023.1	—	1435-1;Ornithine from: 1435-1	`C/C=C/C=C/C=C/C=C/C(CC(N[C@@H](CCCN)C(O)=O)=O)=O`	—
3	`1435-3`	AJD77023.1	—		`C/C=C/C=C/C=C/C=C/C=C/C(O)=O`	{'Iteration': [(['None'], 'M…
4	`1435-4`	AJD77023.1	—	1435-2;1435-3 from: 1435-2, 1435-3	`C/C=C/C=C/C=C/C=C/C(CC(N[C@@H](CCCNC(/C=C/C=C/C=C/C=C/C=C/C)=O)C(O)=O)=O)=O`	—
5	`1435-5`	AJD77023.1	TE	1435-4 from: 1435-4	`O=C(/C=C/C=C/C=C/C=C/C=C/C)NCCC[C@H]1NC(C(C(/C=C/C=C/C=C/C=C/C)=O)=C1O)=O`	—
6	`1435-6`	AJD77024.1	—	1435-5 from: 1435-5	`CC[C@H]([C@H](C)CC([H])C([H])/C=C/C=C/C(C1=C2O)=O)C([H])CCC([H])/C=C/C=C/C(NCCC[C@H]2NC1=O)=O`	—
7	`1435-7`	(AJD77024.1/Spontaneous)?	—	1435-6 from: 1435-6	`CC[C@H]1[C@]2([H])C=C[C@@](/C=C/C=C/C(NCCC[C@H]3NC4=O)=O)([H])[C@@](/C=C/C=C/C(C4=C3O)=O)([H])[C@@]2([H])C[C@H]1C`	—
8	`1435`	AJD77025.1	—	1435-7 from: 1435-7	`CC[C@H]1[C@]2([H])C=C[C@@]([C@H]3C/C=C\C(NCCC[C@H]4NC5=O)=O)([H])[C@@](C=C3/C=C/C(C5=C4O)=O)([H])[C@@]2([H])C[C@H]1C`	—

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