NPdia

← Back to Repository

BGC0001433PKS

Argimycin PI;Argimycin PII;Nigrifactin;Argimycin PIV;Argimycin PV;Argimycin PVI;Argimycin PIX

Producing organism: Streptomyces argillaceus
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: PKS (Type I)
Total steps: 22
DOI: 10.3389/fmicb.2017.00194 10.3389/fmicb.2018.00252
MIBiG entry: View on MIBiG ↗

Loading…

C₁₇H₁₈N₂O₃S330.10 Da

Gene Cluster Map37 genes · 68,295 bp

Biosynthetic (core)

Biosynthetic (additional)

Regulatory

Unknown

Domains

Ketosynthase (KS)

Acyltransferase (AT)

Dehydratase (DH)

Ketoreductase (KR)

Acyl carrier protein (ACP)

Acyl carrier (ACP)

Thioesterase (TE)

Docking N-term

Docking C-term

Methyltransferase

Terminal reductase

CoA-ligase (CAL)

Aminotransferase III

Pathway Graphsteps arranged in biosynthetic order

22 steps · 15 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions22 steps

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`1433-1`	arpPI	Loading	Malonyl-CoA	`O=C(O)C`	—
2	`1433-2`	arpPI	M1	1433-1;Malonyl-CoA from: 1433-1	`C/C=C/C(O)=O`	—
3	`1433-3`	arpPI	M2	1433-2;Malonyl-CoA from: 1433-2	`C/C=C/C=C/C(O)=O`	—
4	`1433-4`	arpPII	M3	1433-3;Malonyl-CoA from: 1433-3	`C/C=C/C=C/C=C/C(O)=O`	—
5	`1433-5`	arpPII	M4	1433-4;Malonyl-CoA from: 1433-4	`C/C=C/C=C/C=C/C(CC(O)=O)=O`	{'Inactive': ['DH', 'KR']}
6	`1433-6`	arpPIII	M5	1433-5;Malonyl-CoA from: 1433-5	`C/C=C/C=C/C=C/C(C[C@@H](O)CC(O)=O)=O`	{'Inactive': ['DH']}
7	`1433-7`	arpPIII	MTD	1433-6 from: 1433-6	`C/C=C/C=C/C=C/C(C[C@@H](O)CC([H])=O)=O`	—
8	`1433-8`	arpN	—	1433-7 from: 1433-7	`C/C=C/C=C/C=C/C(C[C@@H](O)CCN)=O`	—
9	`1433-9`	?	—	1433-8 from: 1433-8	`C/C=C/C=C/C=C/C1=NCC[C@H](O)C1`	—
10	`1433(1)`	?	—	1433-9 from: 1433-9	`C/C=C/C=C/C=C/C1=NCCCC1`	—
11	`1433(2)`	arpDHII	—	1433(1)	`C/C=C/C=C/C=C/C1CCCCN1`	—
12	`1433(3)`	arpDHI	—	1433(2)	`C/C=C/C=C/CCC1CCCCN1`	—
13	`1433(4)`	arpDHI	—	1433(2)	`C/C=C/C=C\CCC1CCCCN1`	—
14	`1433-10`	arpDHII	—	1433-9 from: 1433-9	`C/C=C/C=C/C=C/C1C[C@@H](O)CCN1`	—
15	`1433(5)`	arpDHI	—	1433-10 from: 1433-10	`C/C=C/C=C\CCC1C2C(O2)CCN1`	—
16	`1433(6)`	arpDHI	—	1433-10 from: 1433-10	`C/C=C/C=C/CCC1C2C(O2)CCN1`	—
17	`1433(7)`	arpHI, arpHII	—	1433(5)/1433(6)	`C/C=C/C=C1C=CC2NCCC(O)C2\1O`	—
18	`1433(8)`	arpHI, arpHII	—	1433(5)/1433(6)	`C/C=C/C=C1C=CC2NCCC([H])C2\1O`	—
19	`1433(9)`	arpHI, arpHII	—	1433(5)/1433(6)	`C/C=C/C=C1C=CC2NCCC([H])C2\1[H]`	—
20	`1433(10)`	arpHI, arpHII	—	1433(5)/1433(6)	`C/C=C/C=C1CCC2NCCC=C2\1`	—
21	`1433(11)`	arpO, arpK?	—	1433(7)/1433(8)/1433(9)/1433(10)	`C/C(SCC(C(O)=O)NC(C)=O)=C/C=C1C=CC2=NC=CC=C2\1`	—
22	`1433(12)`	arpO, arpK?	—	1433(7)/1433(8)/1433(9)/1433(10)	`C/C(SCC(C(O)=O)NC(C)=O)=C\C=C1C=CC2=NC=CC=C2/1`	—

Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture