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BGC0001414NRPS

Griselimycin

Producing organism
Streptomyces muensis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
13
DOI
MIBiG entry
View on MIBiG ↗
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griselimycin
C57H96N10O121112.72 Da

Gene Cluster Map26 genes · 66,865 bp

AAAAAAAAAA10 kb66.9 kb visible · 66,865 bp total
Biosynthetic (core)
Biosynthetic (additional)
Unknown
Domains
EREnoylreductase (ER)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
CcCOM C-term
TEThioesterase (TE)
EEpimerization (E)
MTMethyltransferase
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

13 steps · 12 edges
Step 1M1
griA
+Valine
Step 2M2
griA
+MethylProline
Step 3M3
griA
+Threonine
Step 4M4
griA
+Leucine
Step 5M5
griA
+MethylProline
Step 6M6
griA
+Leucine
Step 7M7
griA;griB
+Valine
Step 8M8
griB
+(Proline/MethylPr…
Step 9M9
griB
+Leucine
Step 10M10
griC
+Glycine
Step 11TE
griC
Step 12TE
griC
Step 13TE
griC
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions13 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11414-1griAM1
Valine
CC(C)[C@H](N(C(C)=O)C)C(O)=O—
21414-2griAM2
1414-1;MethylProline
from: 1414-1
CC(C)[C@H](N(C(C)=O)C)C(N1[C@H](C(O)=O)C[C@@H](C)C1)=O—
31414-3griAM3
1414-2;Threonine
from: 1414-2
CC(C)[C@H](N(C(C)=O)C)C(N1[C@H](C(N(C)C(C(C)O)C(O)=O)=O)C[C@@H](C)C1)=O—
41414-4griAM4
1414-3;Leucine
from: 1414-3
CC(C)[C@H](N(C(C)=O)C)C(N1[C@H](C(N(C)C(C(C)O)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)C[C@@H](C)C1)=O—
51414-5griAM5
1414-4;MethylProline
from: 1414-4
CC(C)[C@H](N(C(C)=O)C)C(N1[C@H](C(N(C)C(C(C)O)C(N[C@@H](CC(C)C)C(N2[C@H](C(O)=O)C[C@@H](C)C2)=O)=O)=O)C[C@@H](C)C1)=O—
61414-6griAM6
1414-5;Leucine
from: 1414-5
CC(C)[C@H](N(C(C)=O)C)C(N1[C@H](C(N(C)C(C(C)O)C(N[C@@H](CC(C)C)C(N2[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)C[C@@H](C)C2)=O)=O)=O)C[C@@H](C)C1)=O—
71414-7griA;griBM7
1414-6;Valine
from: 1414-6
CC(C)[C@H](N(C(C)=O)C)C(N1[C@H](C(N(C)C(C(C)O)C(N[C@@H](CC(C)C)C(N2[C@H](C(N[C@H](C(N([C@H](C(O)=O)C(C)C)C)=O)CC(C)C)=O)C[C@@H](C)C2)=O)=O)=O)C[C@@H](C)C1)=O—
81414-8griBM8
1414-7;(Proline/MethylProline)
from: 1414-7
CC(C)[C@H](N(C(C)=O)C)C(N1[C@H](C(N(C)C(C(C)O)C(N[C@@H](CC(C)C)C(N2[C@H](C(N[C@H](C(N([C@H](C(N3[C@H](C(O)=O)C[C@@H]([R])C3)=O)C(C)C)C)=O)CC(C)C)=O)C[C@@H](C)C2)=O)=O)=O)C[C@@H](C)C1)=O—
91414-9griBM9
1414-8;Leucine
from: 1414-8
CC(C)[C@H](N(C(C)=O)C)C(N1[C@H](C(N(C)C(C(C)O)C(N[C@@H](CC(C)C)C(N2[C@H](C(N[C@H](C(N([C@H](C(N3[C@H](C(N([C@@H](C(O)=O)CC(C)C)C)=O)C[C@@H]([R])C3)=O)C(C)C)C)=O)CC(C)C)=O)C[C@@H](C)C2)=O)=O)=O)C[C@@H](C)C1)=O—
101414-10griCM10
1414-9;Glycine
from: 1414-9
CC(C)[C@H](N(C(C)=O)C)C(N1[C@H](C(N(C)C(C(C)O)C(N[C@@H](CC(C)C)C(N2[C@H](C(N[C@H](C(N([C@H](C(N3[C@H](C(N([C@@H](C(NCC(O)=O)=O)CC(C)C)C)=O)C[C@@H]([R])C3)=O)C(C)C)C)=O)CC(C)C)=O)C[C@@H](C)C2)=O)=O)=O)C[C@@H](C)C1)=O—
111414-11griCTE
1414-10
from: 1414-10
CC(N([C@H](C(N1[C@H](C(N(C)[C@]([C@H](C)OC(CNC([C@@H](CC(C)C)N(C([C@@H]2C[C@@H]([R])CN2C([C@@H](N3C)C(C)C)=O)=O)C)=O)=O)([H])C(NC(C(N4[C@H](C(N[C@@H](CC(C)C)C3=O)=O)CC(C)C4)=O)CC(C)C)=O)=O)C[C@@H](C)C1)=O)C(C)C)C)=O—
121414(1)griCTE
1414-10
from: 1414-10
CC(N([C@H](C(N1[C@H](C(N(C)[C@]([C@H](C)OC(CNC([C@@H](CC(C)C)N(C([C@@H]2CC([H])CN2C([C@@H](N3C)C(C)C)=O)=O)C)=O)=O)([H])C(NC(C(N4[C@H](C(N[C@@H](CC(C)C)C3=O)=O)CC(C)C4)=O)CC(C)C)=O)=O)C[C@@H](C)C1)=O)C(C)C)C)=O—
131414(2)griCTE
1414-10
from: 1414-10
CC(N([C@H](C(N1[C@H](C(N(C)[C@]([C@H](C)OC(CNC([C@@H](CC(C)C)N(C([C@@H]2C[C@@H](C)CN2C([C@@H](N3C)C(C)C)=O)=O)C)=O)=O)([H])C(NC(C(N4[C@H](C(N[C@@H](CC(C)C)C3=O)=O)CC(C)C4)=O)CC(C)C)=O)=O)C[C@@H](C)C1)=O)C(C)C)C)=O—
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