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BGC0001409PKS

Dutomycin

Producing organism
Streptomyces minoensis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
12
DOI
MIBiG entry
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dutomycin
C44H54O17854.34 Da

Gene Cluster Map49 genes · 59,215 bp

ERAKSKSKSATER10 kb59.2 kb visible · 59,215 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
CycPolyketide cyclase
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

12 steps · 12 edges
Step 1
dutA, dutB, dutC
+Malonyl-CoA, Malonyl-CoA
Step 5
Start
Step 11
dutG
Iterative
Step 2
dutD, dutE, dutF
Step 6
dutS1
Step 3
dutO1, dutO2, dutO3, du…
Step 7
dutS2, dutS3, dutS4, du…
Step 8
dutS2, dutS3, dutS4, du…
Step 4
dutMT1, dutMT2
Step 9
dutGT1
Step 10
dutGT2
Step 12
dutH
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions12 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11409-1dutA, dutB, dutC—
Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA
CC(CC(CC(CC(CC(CC(CC(CC(CC(CC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O—
21409-2dutD, dutE, dutF—
1409-1
from: 1409-1
OC1=CC2=CC3=CC4=C(C(O)=C3C(O)=C2C(O)=C1C(C)=O)C(O)=CC(O)=C4—
31409-3dutO1, dutO2, dutO3, dutO4—
1409-2
from: 1409-2
OC1=CC(C(C(O)=C(C([C@@](C(C(C(C)=O)=C(O)[C@H]2O)=O)(O)[C@@]2(O)C3)=O)C3=C4)=C4C1=O)=O—
41409-4dutMT1, dutMT2—
1409-3
from: 1409-3
OC1=CC(C(C(O)=C(C([C@@](C(C(C(C)=O)=C(O)[C@H]2O)=O)(O)[C@@]2(O)C3)=O)C3=C4C)=C4C1=O)=O—
51409-5Start—
O[C@H]1[C@H](O)[C@@H](O)[C@@H]([R])O[C@@H]1CO—
61409-6dutS1—
1409-5
from: 1409-5
O[C@H]1[C@H](O)[C@@H](O)[C@@H]([R])O[C@@H]1CO—
71409-7dutS2, dutS3, dutS4, dutS5, dutS6, dutS7, dutS8, dutS9—
1409-6
from: 1409-6
O[C@H]1CC[C@@H]([R])O[C@@H]1C—
81409-8dutS2, dutS3, dutS4, dutS5, dutS6, dutS7, dutS8, dutS9—
1409-6
from: 1409-6
C[C@H]1[C@@H](O)[C@@](O)(C)C[C@@H]([R])O1—
91409-9dutGT1—
1409-4;1409-7
from: 1409-4, 1409-7
OC1=CC(C(C(O)=C(C([C@@](C(C(C(C)=O)=C(O)[C@H]2O[C@H]3CC[C@H](O)[C@@H](C)O3)=O)(O)[C@@]2(O)C4)=O)C4=C5C)=C5C1=O)=O—
101409-10dutGT2—
1409-9;1409-8
from: 1409-9, 1409-8
OC1=CC(C(C(O)=C(C([C@@](C(C(C(C)=O)=C(O)[C@H]2O[C@H]3CC[C@H](O[C@@H]4O[C@@H](C)[C@@H](O)[C@@](O)(C)C4)[C@@H](C)O3)=O)(O)[C@@]2(O)C5)=O)C5=C6C)=C6C1=O)=O—
111409-11dutG—
O=C(O)/C(C)=C\C(C)CCC{'Iteration': [(['DH', 'KR',…
121409dutH—
1409-10;1409-11
from: 1409-10, 1409-11
OC1=CC(C(C(O)=C(C([C@@](C(C(C(C)=O)=C(O)[C@H]2O[C@H]3CC[C@H](O[C@@H]4O[C@@H](C)[C@@H](OC(/C(C)=C\[C@H](C)CCC)=O)[C@@](O)(C)C4)[C@@H](C)O3)=O)(O)[C@@]2(O)C5)=O)C5=C6C)=C6C1=O)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture