NPdia
← Back to Repository
BGC0001406NRPS

Telomycin

Producing organism
Streptomyces canus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces›Streptomyces aurantiacus group
Biosynthetic class
NRPS (Type I)
Total steps
20
DOI
MIBiG entry
View on MIBiG ↗
Loading…
telomycin
C59H77N13O191271.55 Da

Gene Cluster Map34 genes · 82,135 bp

CALAAAAAAAAAAA20 kb82.1 kb visible · 82,135 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
EREnoylreductase (ER)
ACPAcyl carrier protein (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
CnCOM N-term
CcCOM C-term
TEThioesterase (TE)
EEpimerization (E)
CALCoA-ligase (CAL)
AmTAminotransferase I/II
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

20 steps · 19 edges
Step 1
Start
+6-methylheptanoic…
Step 12
Start
+Tryptophan
Step 2
tlo18
Step 13
tlo27
Step 3
tlo19
Step 14
tlo27
Step 4M1
tlo20
+Aspartic acid
Step 15
tlo27
Step 5M2
tlo20
+Serine
Step 6M3
tlo20
+Threonine
Step 7M4
tlo20
+Threonine
Step 8M5
tlo21
+Alanine
Step 9M6
tlo21
+Glycine
Step 10M7
tlo21
+Proline
Step 11M8
tlo21
+Tryptophan
Step 16M9
tlo21
Step 17M10
tlo22
+Leucine
Step 18M11
tlo22
+Proline
Step 19TE
tlo22, (tlo23, tlo29, t…
Step 20
tlo25
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions20 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11406-1Start—
6-methylheptanoic acid
OC(CCCCC(C)C)=O—
21406-2tlo18—
1406-1
from: 1406-1
[R]C(CCCCC(C)C)=O—
31406-3tlo19—
1406-2
from: 1406-2
OC(CCCCC(C)C)=O—
41406-4tlo20M1
1406-3;Aspartic acid
from: 1406-3
OC([C@H](CC(O)=O)NC(CCCCC(C)C)=O)=O—
51406-5tlo20M2
1406-4;Serine
from: 1406-4
O=C([C@@H](NC(C[C@@H](C(O)=O)NC(CCCCC(C)C)=O)=O)CO)O—
61406-6tlo20M3
1406-5;Threonine
from: 1406-5
OC([C@H](CC(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(O)=O)=O)=O)NC(CCCCC(C)C)=O)=O—
71406-7tlo20M4
1406-6;Threonine
from: 1406-6
O=C([C@@H](NC([C@@H](NC([C@@H](NC(C[C@@H](C(O)=O)NC(CCCCC(C)C)=O)=O)CO)=O)[C@@H](C)O)=O)[C@@H](O)C)O—
81406-8tlo21M5
1406-7;Alanine
from: 1406-7
OC([C@H](CC(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](C)O)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)NC(CCCCC(C)C)=O)=O—
91406-9tlo21M6
1406-8;Glycine
from: 1406-8
O=C(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(C[C@@H](C(O)=O)NC(CCCCC(C)C)=O)=O)CO)=O)[C@@H](C)O)=O)[C@@H](O)C)=O)C)=O)O—
101406-10tlo21M7
1406-9;Proline
from: 1406-9
O=C([C@H]1N(C(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(C[C@@H](C(O)=O)NC(CCCCC(C)C)=O)=O)CO)=O)[C@@H](C)O)=O)[C@@H](O)C)=O)C)=O)=O)CCC1)O—
111406-11tlo21M8
1406-10;Tryptophan
from: 1406-10
OC([C@H](CC(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](C)O)C(N[C@@H](C)C(NCC(N1CCC[C@H]1C(N/C(C(O)=O)=C\C2=CNC3=C2C=CC=C3)=O)=O)=O)=O)=O)=O)=O)NC(CCCCC(C)C)=O)=O—
121406-12Start—
Tryptophan
NC(C(O)=O)CC1=CNC2=CC=CC=C12—
131406-13tlo27—
1406-12
from: 1406-12
O=C(C(O)=O)CC1=CNC2=CC=CC=C12—
141406-14tlo27—
1406-13
from: 1406-13
O=C(C(O)=O)C(C)C1=CNC2=CC=CC=C12—
151406-15tlo27—
1406-14
from: 1406-14
O=C(O)C(N)C(C)C1=CNC2=CC=CC=C12—
161406-16tlo21M9
1406-11;1406-15
from: 1406-11, 1406-15
O=C([C@@H](NC(/C(NC([C@H]1N(C(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(C[C@@H](C(O)=O)NC(CCCCC(C)C)=O)=O)CO)=O)[C@@H](C)O)=O)[C@@H](O)C)=O)C)=O)=O)CCC1)=O)=C/C2=CNC3=C2C=CC=C3)=O)[C@@H](C)C4=CNC5=C4C=CC=C5)O—
171406-17tlo22M10
1406-16;Leucine
from: 1406-16
OC([C@H](CC(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](C)O)C(N[C@@H](C)C(NCC(N1CCC[C@H]1C(N/C(C(N[C@@H]([C@H](C2=CNC3=C2C=CC=C3)C)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=C\C4=CNC5=C4C=CC=C5)=O)=O)=O)=O)=O)=O)=O)NC(CCCCC(C)C)=O)=O—
181406-18tlo22M11
1406-17;Proline
from: 1406-17
OC([C@H](CC(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](C)O)C(N[C@@H](C)C(NCC(N1CCC[C@H]1C(N/C(C(N[C@@H]([C@H](C2=CNC3=C2C=CC=C3)C)C(N[C@@H](CC(C)C)C(N4[C@H](C(O)=O)CCC4)=O)=O)=O)=C\C5=CNC6=C5C=CC=C6)=O)=O)=O)=O)=O)=O)=O)NC(CCCCC(C)C)=O)=O—
191406-19tlo22, (tlo23, tlo29, tlo32)TE
1406-18
from: 1406-18
O=C(N[C@H](C(N[C@H](C(N[C@@H]([C@H](C)O)C(N[C@H](C(NCC(N1[C@@H]([C@@H](O)CC1)C2=O)=O)=O)C)=O)=O)[C@H](OC([C@@H]3[C@H](O)CCN3C([C@@H](NC([C@@H](NC(/C(N2)=C\C4=CNC5=C4C=CC=C5)=O)[C@@H](C)C6=CNC7=C6C=CC=C7)=O)[C@H](C(C)C)O)=O)=O)C)=O)CO)C[C@@H](C(O)=O)NC(CCCCC(C)C)=O—
201406tlo25—
1406-19
from: 1406-19
O=C(N[C@H](C(N[C@H](C(N[C@@H]([C@H](C)O)C(N[C@H](C(NCC(N1[C@@H]([C@@H](O)CC1)C2=O)=O)=O)C)=O)=O)[C@H](OC([C@@H]3[C@H](O)CCN3C([C@@H](NC([C@@H](NC(/C(N2)=C\C4=CNC5=C4C=CC=C5)=O)[C@@H](C)C6=CNC7=C6C=CC=C7)=O)[C@H](C(C)C)O)=O)=O)C)=O)CO)C[C@@H](C(O)=O)N—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture