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BGC0001396PKS

Aldgamycin J;Aldgamycin K;Aldgamycin P;Aldgamycin E

Producing organism
Streptomyces sp. A1(2016)
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
19
DOI
MIBiG entry
View on MIBiG ↗
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C36H60O15732.39 Da

Gene Cluster Map38 genes · 81,762 bp

KSKSKSKSKSKSKSKS20 kb81.8 kb visible · 81,762 bp total
Biosynthetic (core)
Biosynthetic (additional)
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
DHtDehydratase (DHt)
AmTAminotransferase I/II
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

19 steps · 19 edges
Step 1Load
almHI
+Malonyl-CoA
Step 11
Start
Step 2M1
almHI
Inactive: KS, KR
Step 12
almBII, almBIII
Step 3M2
almHI
+Methylmalonyl-CoA
Step 13
almCI
Step 4M3
almHI
+Malonyl-CoA
Step 14
almDI, almDII
Step 5M4
almHII
+Malonyl-CoA
Step 6M5
almHIII
+Methylmalonyl-CoA
Inactive: KR
Step 7M6
almHIII
+Methylmalonyl-CoA
Step 8M7
almHIV
+Methylmalonyl-CoA
Step 9M8
almHV
+Malonyl-CoA
Step 10TE
almHV
+Methylmalonyl-CoA
Step 15
?
Step 16
?
Step 17
?
Step 18
?
Step 19
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions19 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11396-1almHILoading
Malonyl-CoA
O=C(O)C—
21396-2almHIM1
1396-1
from: 1396-1
O=C(O)C{'Inactive': ['KS', 'KR']}
31396-3almHIM2
1396-2;Methylmalonyl-CoA
from: 1396-2
O[C@@H]([C@@H](C)C(O)=O)C—
41396-4almHIM3
1396-3;Malonyl-CoA
from: 1396-3
O[C@@H]([C@@H](C)/C=C/C(O)=O)C—
51396-5almHIIM4
1396-4;Malonyl-CoA
from: 1396-4
O[C@@H]([C@@H](C)/C=C/C=C/C(O)=O)C—
61396-6almHIIIM5
1396-5;Methylmalonyl-CoA
from: 1396-5
O[C@@H]([C@@H](C)/C=C/C=C/C([C@H](C)C(O)=O)=O)C{'Inactive': ['KR']}
71396-7almHIIIM6
1396-6;Methylmalonyl-CoA
from: 1396-6
O[C@@H]([C@@H](C)/C=C/C=C/C([C@H](C)C[C@H](C)C(O)=O)=O)C—
81396-8almHIVM7
1396-7;Methylmalonyl-CoA
from: 1396-7
O[C@@H]([C@@H](C)/C=C/C=C/C([C@H](C)C[C@H](C)[C@H](O)[C@@H](C)C(O)=O)=O)C—
91396-9almHVM8
1396-8;Malonyl-CoA
from: 1396-8
O[C@@H]([C@@H](C)/C=C/C=C/C([C@H](C)C[C@H](C)[C@H](O)[C@@H](C)C(CC(O)=O)=O)=O)C—
101396-10almHVTE
1396-9;Methylmalonyl-CoA
from: 1396-9
C[C@H]([C@@H](C)OC1=O)/C=C/C=C/C([C@H](C)C[C@H](C)[C@H](O)[C@@H](C)CC1=O)=O—
111396-11Start—
O=C1[C@H](O)[C@@H](O)[C@@H]([R])O[C@@H]1C—
121396-12almBII, almBIII—
1396-11
from: 1396-11
C[C@H]1O[C@H]([R])[C@H](O)C(C1)=O—
131396-13almCI—
1396-12
from: 1396-12
C[C@H]1O[C@H]([R])[C@H](O)[C@@H](O)C1—
141396-14almDI, almDII—
1396-13
from: 1396-13
C[C@H]1O[C@H]([R])[C@H](O)[C@@](O)(C(C)=O)C1—
151396-15?—
1396-10;1396-13;1396-14
from: 1396-10, 1396-13, 1396-14
C[C@@H](O1)[C@@H](CO[C@@H]2O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]2OC)[C@H](O3)[C@@H]3/C=C/C([C@@](C)(O)C[C@H](C)[C@H](O[C@H]4[C@H](O)[C@]5(OC(O[C@H]5C)=O)C[C@@H](C)O4)[C@@H](C)/C=C/C1=O)=O—
161396(1)?—
1396-15
from: 1396-15
C[C@@H](O1)[C@@H](CO[C@@H]2O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]2OC)[C@H](O3)[C@@H]3CCC([C@@](C)(O)C[C@H](C)[C@H](O[C@H]4[C@H](O)[C@@](O)([C@@H](O)C)C[C@@H](C)O4)[C@@H](C)/C=C/C1=O)=O—
171396(2)?—
1396-15
from: 1396-15
C[C@@H](O1)[C@@H](CO[C@@H]2O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]2OC)[C@H](O3)[C@@H]3CCC([C@H](C)C[C@H](C)[C@H](O[C@H]4[C@H](O)[C@@](O)([C@@H](O)C)C[C@@H](C)O4)[C@@H](C)/C=C/C1=O)=O—
181396(3)?—
1396-15
from: 1396-15
C[C@@H](O1)[C@@H](CO[C@@H]2O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]2OC)[C@H](O3)[C@@H]3CCC([C@@](C)(O)C[C@H](C)[C@H](O[C@H]4[C@H](O)[C@@](OC5=O)([C@@H](O5)C)C[C@@H](C)O4)[C@@H](C)/C=C/C1=O)=O—
191396(4)?—
1396-15
from: 1396-15
C[C@@H](O1)[C@@H](CO[C@@H]2O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]2OC)[C@H](O3)[C@@H]3CCC([C@H](C)C[C@H](C)[C@H](O[C@H]4[C@H](O)[C@@](OC5=O)([C@@H](O5)C)C[C@@H](C)O4)[C@@H](C)/C=C/C1=O)=O—
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