NPdia

BGC0001384PKS

Saprolmycin E

Producing organism: Streptomyces sp. TK08046
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: PKS (Unknown)
Total steps: 9
DOI: 10.1080/09168451.2016.1196574
MIBiG entry: View on MIBiG ↗

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saprolmycin E

C₄₃H₄₈O₁₆820.29 Da

Biosynthetic (core)

Biosynthetic (additional)

Regulatory

Transport

Unknown

Domains

Ketosynthase (KS)

Acyltransferase (AT)

Ketoreductase (KR)

Acyl carrier protein (ACP)

Acyl carrier (ACP)

Polyketide cyclase

ACP synthase

NAD-binding

9 steps · 8 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`1384-1`	sprD, sprE, sprF, sprG	—	Acetyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA	`OC1CC(C(C(CC(CC(CC(C)=O)=O)=O)=O)C(CC(CC(CC(O)=O)=O)=O)(O)C1)=O`	—
2	`1384-2`	sprH	—	1384-1 from: 1384-1	`OC1(CC(CC(CC(O)=O)=O)=O)=CC=CC(O)=C1C(CC(CC(CC(C)=O)=O)=O)=O`	—
3	`1384-3`	sprC	—	1384-2 from: 1384-2	`OC1=C(C(O)=C(C(CC(CC(O)(C)C2)(O)C3C2=O)=O)C3=C4)C4=CC=C1`	—
4	`1384-4`	sprI	—	1384-3 from: 1384-3	`OC1=C(C(O)=C(C(CC(CC(O)(C)C2)(O)C3(O)C2=O)=O)C3=C4)C4=CC=C1`	—
5	`1384-5`	sprB	—	1384-4 from: 1384-4	`OC1=CC=CC(C2=O)=C1C(C3=C2C4(O)C(CC(O)(C)CC4=O)(O)C=C3)=O`	—
6	`1384-6`	Start	—	Aculose	`OC1OC(C)C(C=C1)=O`	—
7	`1384-7`	Start	—	Olivose	`O[C@@H]1[C@@H](O)CC(O)O[C@H]1C`	—
8	`1384-8`	Start	—	Rhodinose	`OC1CCC(O)C(C)O1`	—
9	`1384`	sprGT1, sprGT2, sprGT3	—	1384-5;1384-6;1384-6;1384-7;1384-8 from: 1384-5, 1384-6, 1384-6, 1384-7, 1384-8	`OC1=C([C@H]2C[C@H](O)[C@@H](OC3CCC(OC4OC(C)C(C=C4)=O)C(C)O3)[C@H](C)O2)C=CC(C5=O)=C1C(C6=C5[C@]7(O)[C@](C[C@@](C)(OC8OC(C)C(C=C8)=O)CC7=O)(O)C=C6)=O`	—

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